D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
![D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Structure](CAS/GIF/117414-74-1.gif)
- CAS No.
- 117414-74-1
- Chemical Name:
- D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID
- Synonyms
- Midafotel;D-CPP-ENE;DCPPene,D CPP ene;(R)-CPPene (SDZ EAA 494);(R,E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID;D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID;(2R)-4-[(E)-3-Phosphono-2-propenyl]piperazine-2β-carboxylic acid;2-Piperazinecarboxylic acid, 4-[(2E)-3-phosphono-2-propenyl]-, (2R)-
- CBNumber:
- CB2158312
- Molecular Formula:
- C8H15N2O5P
- Molecular Weight:
- 250.19
- MDL Number:
- MFCD00878116
- MOL File:
- 117414-74-1.mol
| Boiling point | 555.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.449±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at RT |
| form | Powder |
| pka | 1.27±0.10(Predicted) |
| color | White |
| Water Solubility | Soluble to 100 mM in water |
| FDA UNII | 7LYU6ZF84G |
D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.04840 | (R)-CPPene - CAS 117414-74-1 - Calbiochem | 117414-74-1 | 10mg | $344 | 2023-06-20 | Buy |
| Tocris | 1265 | D-CPP-ene | 117414-74-1 | 10 | $414 | 2021-12-16 | Buy |
| Usbiological | 255089 | D-CPP-ene | 117414-74-1 | 10mg | $715 | 2021-12-16 | Buy |
| TRC | C781465 | D-CPP-ene | 117414-74-1 | 25mg | $1200 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | RDL0008216 | D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID 98.00% | 117414-74-1 | 0.1G | $1045 | 2021-12-16 | Buy |
D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Chemical Properties,Uses,Production
Uses
D-CPP-ene is a potent, competitive NMDA antagonist (1). NMDA antagonists such as this may increase sucrose intake through hunger satiation delay (2).
Definition
ChEBI: Midafotel is a member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued). It has a role as a NMDA receptor antagonist, a neuroprotective agent and an anticonvulsant. It is a piperazinecarboxylic acid, a monocarboxylic acid, a member of phosphonic acids, an olefinic compound and a tertiary amino compound.
Biological Activity
Potent and competitive NMDA antagonist (K i = 40 nM). Centrally active following systemic administration.
storage
Room temperature
D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Preparation Products And Raw materials
D-4-[(2E)-3-PHOSPHONO-2-PROPENYL]-2-PIPERAZINECARBOXYLIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Synchem OHG | +49 5662 408730 | info@synchem.de | Germany | 4708 | 70 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4030 | 58 |