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BESTATIN HYDROCHLORIDE

BESTATIN HYDROCHLORIDE structure

CAS No.: 65391-42-6

Chemical Name:: BESTATIN HYDROCHLORIDE

Synonyms: BESTATIN HCL;Bestatin.HCI;Ubenimex HCl;Ubenimex-d7 HCl;BESTATIN HYDROCHLORIDE;Ubenimex hydrochloride;HYDROCHLORIDE,Ubenimex;Bestatin research grade;BESTATIN HYDROCHLORIDE USP/EP/BP;Bestatin-d7 HCl (Ubenimex-d7 HCl)

CBNumber:: CB2172341

Molecular Formula:: C16H25ClN2O4

Molecular Weight:: 344.83

MDL Number:: MFCD00058004

MOL File:: 65391-42-6.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:05

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BESTATIN HYDROCHLORIDE Properties

Melting point	216-218 °C
storage temp.	2-8°C
solubility	H₂O: 25 mg/mL, clear, colorless
form	White to off-white powder.
color	White
Water Solubility	Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.
BRN	4628066
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO, distilled water, or ethanol may be stored at -20° for up to 1 month.
InChIKey	XGDFITZJGKUSDK-UDYGKFQRSA-N
CAS DataBase Reference	65391-42-6(CAS DataBase Reference)
FDA UNII	BY7Y2JX7NQ

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-24/25-36-26
WGK Germany	3
F	3-10
HS Code	29242995

BESTATIN HYDROCHLORIDE price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B8385	Bestatin hydrochloride ≥98% (HPLC)	65391-42-6	1mg	$76.9	2024-03-01	Buy
Sigma-Aldrich	B8385	Bestatin hydrochloride ≥98% (HPLC)	65391-42-6	5mg	$164	2024-03-01	Buy
Sigma-Aldrich	10874515001	Bestatin [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucinehydrochloride	65391-42-6	10mg	$244	2022-05-15	Buy
TCI Chemical	B4000	N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride >97.0%(HPLC)	65391-42-6	25mg	$194	2024-03-01	Buy
Alfa Aesar	J60384	Bestatin hydrochloride, 98%	65391-42-6	5mg	$87.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
B8385	1mg	$76.9	Buy
B8385	5mg	$164	Buy
10874515001	10mg	$244	Buy
B4000	25mg	$194	Buy
J60384	5mg	$87.65	Buy

BESTATIN HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor activity.

Uses

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Uses

competitive aminopeptidase B inhibitor

Uses

Bestatin Hydrochloride is an inhibitor of aminopeptidases, LAP3, and leukotriene A4 hydrolase. It is the salt form of Bestatin (B319500).

Uses

Bestatin has been used as a protease inhibitor for the purification of his-tagged Tau protein.

Definition

ChEBI: Bestatin (hydrochloride) is a peptide.

General Description

Chemical structure: amino acid derivatives

Biochem/physiol Actions

A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.

in vivo

in a mouse dorsal air sac assay, oral administration of bestatin (100-200 mg/kg/day) showed a significant inhibitory activity against the melanoma cell-induced angiogenesis. bestatin also inhibited the tube-like formation of human umbilical vein endothelial cells (huvecs). furthermore, after the orthotopic implantation of b16-bl6 melanoma cells into mice, bestatin administration (50-100 mg/kg/day, i.p) reduced the number of vessels oriented towards the established primary tumor mass on the dorsal side of mice [1].

References

1) Orning et al. (1991), Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes; J. Biol. Chem., 266 1375 2) Wang et al. (2010), The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor; Biol. Pharm. Bull., 33 1658

BESTATIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

BESTATIN HYDROCHLORIDE Suppliers

Global( 151)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Dideu Industries Group Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Henan Alfa Chemical Co., Ltd	58
Nextpeptide Inc	58

View Lastest Price from BESTATIN HYDROCHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	Bestatin hydrochloride 65391-42-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	Bestatin hydrochloride 65391-42-6	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	BESTATIN HYDROCHLORIDE 65391-42-6	US $150.00 / KG	1KG	98%	10000kg	Career Henan Chemical Co

Bestatin hydrochloride
65391-42-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Bestatin hydrochloride
65391-42-6
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BESTATIN HYDROCHLORIDE
65391-42-6
US $150.00 / KG
98%
Career Henan Chemical Co

65391-42-6(BESTATIN HYDROCHLORIDE)Related Search:

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N-CARBOBENZOXY-DL-LEUCINE 1,3-Diamino-2-propanol Bestatin N-(2-HYDROXYETHYL)LACTAMIDE BESTATIN HYDROCHLORIDE

(R)-(-)-4-PHENYL-2-BUTANOL D(+)-Phenylalaninol H-BETA-ALA-NH2 HCL 1,3-Dimethylbutylamine L-Leucine hydrochloride

DIETHANOLAMINE HYDROCHLORIDE Betaine hydrochloride N-(3-AMINOPROPYL)GLYCINE DIHYDROCHLORIDE

1of4

N-[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE HYDROCHLORIDE N-(3R-AMINO-2S-HYDROXY-1-OXO-4-PHENYLBUTYL)-L-LEUCINE, MONOHYDROCHLORIDE [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HCL [(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE HYDROCHLORIDE (AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE HYDROCHLORIDE BESTATIN HCL BESTATIN HYDROCHLORIDE N-(2S,3R-3-AMINO-2-HYDROXY-4-PHENYLBUTY- RYL)-L-LEUCINE HCL Bestatin.HCI N-(3-Amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine monohydrochloride (S)-2-((2S,3R)-3-aMino-2-hydroxy-4-phenylbutanaMido)-4-Methylpentanoic acid hydrochloride L-Leucine,N-[(2S,3R)-3-aMino-2-hydroxy-1-oxo-4-phenylbutyl]-, hydrochloride (1:1) Ubenimex hydrochloride Bestatin research grade Ubenimex Hydrochloride [for Biochemical Research] Bestatin-d7 HCl (Ubenimex-d7 HCl) Ubenimex-d7 HCl HYDROCHLORIDE,Ubenimex Bestatin hydrochloride, ≥98% (HPLC) N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Hydrochloride > BESTATIN HYDROCHLORIDE USP/EP/BP Ubenimex-d7 HClQ: What is Ubenimex-d7 HCl Q: What is the CAS Number of Ubenimex-d7 HCl (4S,5R)-5-amino-4-hydroxy-2-(2-methylpropyl)-3-oxo-6-phenyl-D-norleucine hydrochloride N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine hydrochloride (S)-2-((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanamido)-4-methylpentanoic acid hydrochloride[Ubenimex Hydrochloride Ubenimex HCl，Bestatin hydrochloride Ubenimex HCl 65391-42-6 C16H24N2O4ClH C16HH24N2O4xHCL Antibiotics A-F Antibiotics A to Z Antibiotics BioChemical peptides Bestatin inhibitor Pepetides