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Clomipramine hydrochloride

Clomipramine hydrochloride
Clomipramine hydrochloride structure
CAS No.
17321-77-6
Chemical Name:
Clomipramine hydrochloride
Synonyms
ANAFRANIL;Clomicalm;anaphranil;Chlomipramine;CLOMIPRAMINE HCL;Chloroimipram-ine HCl;ANAFRANIL HYDROCHLORIDE;Clomipraminhydrochlorid;Clomipramine-13C-d3 HCl;CLOMIPRAMINE HYDROCHLORIDE
CBNumber:
CB2173106
Molecular Formula:
C19H24Cl2N2
Formula Weight:
351.31
MOL File:
17321-77-6.mol

Clomipramine hydrochloride Properties

Melting point:
189-190°C
Flash point:
9℃
storage temp. 
Store at RT
solubility 
H2O: 25 mg/mL
form 
powder
color 
white to off-white
PH
3.5~5.0(100g/l,25℃)
InChIKey
WIMWMKZEIBHDTH-UHFFFAOYSA-N
CAS DataBase Reference
17321-77-6(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS09,GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H302-H361d-H410-H225-H301+H311+H331-H370-H312-H332-H360
Precautionary statements  P301+P312+P330-P210-P260-P280-P301+P310-P311-P201-P261-P304+P340-P405-P501a
Hazard Codes  Xn,T,F
Risk Statements  20/21/22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  36-45-36/37-16-7-62-38-36/37/39-28-26-24/25-22-20/21-13
RIDADR  3249
WGK Germany  3
RTECS  HN9055000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933996100

Clomipramine hydrochloride price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C-118 Clomipramine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material 17321-77-6 118-1ml $19.1 2018-11-13 Buy
Sigma-Aldrich 1140247 Clomipramine hydrochloride United States Pharmacopeia (USP) Reference Standard 17321-77-6 200mg $348 2018-11-13 Buy
Alfa Aesar J62485 Clomipramine hydrochloride 17321-77-6 1g $27.5 2018-11-13 Buy
Alfa Aesar J62485 Clomipramine hydrochloride 17321-77-6 5g $96.3 2018-11-13 Buy
Cayman Chemical 15884 Clomipramine (hydrochloride) ≥98% 17321-77-6 1g $29 2018-11-13 Buy

Clomipramine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Serotonin reuptake inhibitor. Antidepressant; antiobsessional agent

Uses

anti-depressant, serotonin uptake inhibitor

Definition

ChEBI: A hydrochloride resulting from the reaction of equimolar amounts of clomipramine and hydrogen chloride. One of the more sedating tricyclic antidepressants, it is used for the treatment of depression as well as obsessive-compulsive disorder and phobias.

brand name

Anafranil (Tyco).

General Description

Clomipramine (Anafranil) is up to 50 times as potentas imipramine in some bioassays. This does not implyclinical superiority, but it might be informative about tricyclicand, possibly, other reuptake inhibitors. The chloro replacingthe H-substituent could increase potency by increasingdistribution to the CNS, but it is unlikely that this wouldgive the potency magnitude seen. It might be conjecturedthat an H-bond between the protonated amino group (as invivo) and the unshared electrons of the chloro substituent might stabilize a β-arylamine–like shape and give moreefficient competition for the transporter. The drug is anantidepressant. It is used in obsessive–compulsive disorder,an anxiety disorder that may have an element of depression.

General Description

Clomipramine (Anafranil) is up to 50 times as potentas imipramine in some bioassays. This does not implyclinical superiority, but it might be informative about tricyclicand, possibly, other reuptake inhibitors. The chloro replacingthe H-substituent could increase potency by increasingdistribution to the CNS, but it is unlikely that this wouldgive the potency magnitude seen. It might be conjecturedthat an H-bond between the protonated amino group (as invivo) and the unshared electrons of the chloro substituent weeks before antidepressant action develops. It is consideredthat (in the case of 5-HT) 5-HT1A receptors and (in the caseof NE) α2 receptors undergo desensitization and transmitterrelease is maintained. Of course, activation of postsynapticreceptors and sustained transmission is the ultimate result ofsustained synaptic levels of neurotransmitter.

Biological Activity

Potent, selective 5-HT uptake blocker. Antidepressant. Binds to the human 5-HT transporter with a K i of 0.05 nmol/l. Also available as part of the Serotonin Uptake Inhibitor Tocriset™ .

Veterinary Drugs and Treatments

In veterinary medicine, clomipramine is used primarily in dogs as a treatment for obsessive-compulsive disorders (ritualistic stereotypical behaviors) and may be useful for dominance aggression and anxiety (separation).
Clomipramine may also be useful in cats, particularly for behaviors such as urine spraying. One prospective, double-blinded controlled study in cats with psychogenic alopecia comparing clomipramine (0.5 mg/kg PO daily) versus placebo showed no statistic differences in study parameters (Mertens, Torres et al. 2006).

Clomipramine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Clomipramine hydrochloride Suppliers

Global( 154)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21676 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 295 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58

View Lastest Price from Clomipramine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Clomipramine hydrochloride
17321-77-6
US $1.00 / kg 1kg 99% Customized career henan chemical co
2018-03-05 Clomipramine hydrochloride
17321-77-6
US $300.00 / KG 1KG 99% 1000000KG Hubei XinRunde Chemical Co., Ltd.

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