TOLRESTAT
- CAS No.
- 82964-04-3
- Chemical Name:
- TOLRESTAT
- Synonyms
- CS-148;Lorestat;AY-27773;Alredase;Aldredase;TOLRESTAT;Tolrestatin;Tolrestat, AY 27773;TOLRESTAT USP/EP/BP;TOLRESTAT(FORR&DONLY)
- CBNumber:
- CB2174693
- Molecular Formula:
- C16H14F3NO3S
- Molecular Weight:
- 357.35
- MDL Number:
- MFCD00864170
- MOL File:
- 82964-04-3.mol
- MSDS File:
- SDS
| Melting point | 164-165° |
|---|---|
| Boiling point | 498.1±55.0 °C(Predicted) |
| Density | 1.399±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | powder |
| pka | 3.49±0.10(Predicted) |
| color | white to beige |
| CAS DataBase Reference | 82964-04-3 |
| FDA UNII | 0T93LG5NMK |
| ATC code | A10XA01 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
TOLRESTAT price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1573 | Tolrestat ≥98% (HPLC) | 82964-04-3 | 5MG | $117 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1573 | Tolrestat ≥98% (HPLC) | 82964-04-3 | 25MG | $478 | 2023-06-20 | Buy |
| Cayman Chemical | 29693 | Tolrestat | 82964-04-3 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29693 | Tolrestat | 82964-04-3 | 25mg | $456 | 2024-03-01 | Buy |
| Cayman Chemical | 29693 | Tolrestat | 82964-04-3 | 1mg | $32 | 2024-03-01 | Buy |
TOLRESTAT Chemical Properties,Uses,Production
Description
Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts.
Description
Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.
Originator
American Home Products (USA)
Uses
Alredase (Wyeth-Ayerst).
Uses
Tolrestat is an aldose reductase inhibitor.
Definition
ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.
brand name
Alredase
Biochem/physiol Actions
Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.
TOLRESTAT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9705 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29627 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
View Lastest Price from TOLRESTAT manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-09 | TOLRESTAT USP/EP/BP
82964-04-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- TOLRESTAT USP/EP/BP
82964-04-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited