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W-7 HYDROCHLORIDE

W-7 HYDROCHLORIDE structure

CAS No.: 61714-27-0

Chemical Name:: W-7 HYDROCHLORIDE

Synonyms: W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium

CBNumber:: CB2182197

Molecular Formula:: C16H22Cl2N2O2S

Molecular Weight:: 377.33

MDL Number:: MFCD00012559

MOL File:: 61714-27-0.mol

Last updated:2023-06-30 15:45:59

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W-7 HYDROCHLORIDE Properties

Melting point	220-222 °C
storage temp.	-20°C
solubility	methanol: 25 mg/mL, clear, colorless
form	Off-white crystalline solid
color	White to Off-White
BRN	6030174
CAS DataBase Reference	61714-27-0(CAS DataBase Reference)
EWG's Food Scores	1

SAFETY

Risk and Safety Statements

Hazard Codes	Xi
Safety Statements	22-24/25
WGK Germany	3
RTECS	QK0786000
F	3-10
HS Code	2935909099

W-7 HYDROCHLORIDE price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A3281	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride	61714-27-0	25mg	$156	2024-03-01	Buy
Sigma-Aldrich	681629	W-7, Hydrochloride	61714-27-0	10mg	$144	2024-03-01	Buy
TCI Chemical	A2409	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride	61714-27-0	100MG	$180	2024-03-01	Buy
TCI Chemical	A2409	N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride	61714-27-0	1G	$647	2024-03-01	Buy
Cayman Chemical	14826	W-7 (hydrochloride) ≥98%	61714-27-0	10mg	$57	2024-03-01	Buy

Product number	Packaging	Price	Buy
A3281	25mg	$156	Buy
681629	10mg	$144	Buy
A2409	100MG	$180	Buy
A2409	1G	$647	Buy
14826	10mg	$57	Buy

W-7 HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Calmodulin is a calcium-dependent protein that regulates the activity of a diverse array of enzymes, ion channels, and other proteins and thus has diverse roles in cell function. W-7 is a cell-permeable antagonist of calmodulin (K_i = 11 μM). Two molecules of W-7 bind to calcium-binding domains in each calmodulin molecule, blocking its interaction with target proteins. W-7 also associates, at lower affinities, with calcium-binding domains of other proteins, including troponin C and myosin light chain kinase (K_i = 70 and 300 μM, respectively).

Chemical Properties

White Crystalline Solid

Uses

N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride has been used to study its effect of on coated pit staining.

Uses

W7 is a vascular relaxing agent which affects vascular smooth muscle actomyosin. W7, an inhibitor of actomyosin superprecipitation, produces relaxation of isolated rabbit arterial strips and antagonizes the contraction of the strips induced by various contractile agonists. W7 is also a calmodulin antagonist that binds to calmodulin and inhibits Ca2+/calmodulin-regulated enzyme activities.

General Description

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 μM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 μM).

Biological Activity

Calmodulin antagonist. Inhibits Ca 2+ -calmodulin-dependent phosphodiesterase (IC 50 = 28 μ M) and myosin light chain kinase (IC 50 = 51 μ M).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at RT

W-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

W-7 HYDROCHLORIDE Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Mainchem Co., Ltd.	55
J & K SCIENTIFIC LTD.	76

W-7 HYDROCHLORIDE Spectrum

W-7 HYDROCHLORIDE(61714-27-0)IR W-7 HYDROCHLORIDE(61714-27-0)Raman

61714-27-0(W-7 HYDROCHLORIDE)Related Search:

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OMEGA-7 HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE W-7 W-7 HYDROCHLORIDE N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7 ulfonaMide W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem CS-1064 6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride > SKL179 6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor 61714-27-0 C16H21ClN2O2SClH Antibiotics Antibiotics A to Z Antibiotics A-F BioChemical All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators Calcium signaling