LATRUNCULIN B
- CAS No.
- 76343-94-7
- Chemical Name:
- LATRUNCULIN B
- Synonyms
- LAT-B;NSC 339663;LATRUNCULIN B;LATRUNCULIN B, LUTRUNCULIA MAGNIFICA;LatrunculinBfromLutrunculiamagnifica;LATRUNCULIN B, LATRUNCULIA MAGNIFICA;Latrunculin B from Latruncula magnifica;Latrunculin B, Latrunculia magnifica - CAS 76343-94-7 - Calbiochem;(4R)-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone;2-Thiazolidinone, 4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-, (4R)-
- CBNumber:
- CB2186645
- Molecular Formula:
- C20H29NO5S
- Molecular Weight:
- 395.51
- MDL Number:
- MFCD00270879
- MOL File:
- 76343-94-7.mol
| alpha | D24 +112° (c = 0.48 in chloroform) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | solid |
| color | light yellow |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | LW7U308U7U |
LATRUNCULIN B price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 428020 | Latrunculin B, | 76343-94-7 | 1mg | $251 | 2024-03-01 | Buy |
| Sigma-Aldrich | 428020 | Latrunculin B, | 76343-94-7 | 5mg | $733 | 2024-03-01 | Buy |
| Cayman Chemical | 10010631 | Latrunculin B ≥97% | 76343-94-7 | 1 mg | $219 | 2024-03-01 | Buy |
| Cayman Chemical | 10010631 | Latrunculin B ≥97% | 76343-94-7 | 50μg | $27 | 2022-04-27 | Buy |
| Cayman Chemical | 10010631 | Latrunculin B ≥97% | 76343-94-7 | 100μg | $51 | 2022-04-27 | Buy |
LATRUNCULIN B Chemical Properties,Uses,Production
Description
Latrunculin B (76343-94-7) inhibits actin polymerization and disrupts microfilament organization.1 Significantly more potent than cytochalasins in the disruption of microfilament mediated processes2, causes shortening and thickening of stress fibers. Active in cell culture.3,4?Effective doses for latrunculin B vary depending upon cell type but are frequently in the low micromolar range. Note: Latrunculin B is slowly inactivated by fetal bovine serum.
Uses
Latrunculin B is an actin polymerization inhibitor.
Uses
Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.
Uses
In elucidation of molecular mechanisms of motile processes.
Definition
ChEBI: A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.
General Description
Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.
Biochem/physiol Actions
Primary TargetActin polymerization
storage
Store at -20°C
References
1) Coue?et al. (1987),?Inhibition of actin polymerization by latrunculin; FEBS Lett.,?213?316 2) Spector?et al. (1989),?Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth; Cell Motil. Cytoskeleton,?13?127 3) Wakatsuki?et al. (2001),?Effects of cytochalasin D and latrunculin B on mechanical properties of cells; J. Cell. Sci.,?114?1025 4) Cha?et al. (2004),?The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2 but is dependent on an intact actin cytoskeleton as determined by FRAP; Prog. Clin. Biol. Res.,?230 4 5) Herrera (2021), Cell cultures, transfection and treatments. protocols.io???https://dx.doi.org/10.17504/protocols.io.77ehrje [Focus Citation]
LATRUNCULIN B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| ChemStrong Scientific Co.,Ltd | 0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |