ChemicalBook
Chinese Japanese Germany Korea

ABT 263

Description In vitro
ABT 263
ABT 263 structure
CAS No.
923564-51-6
Chemical Name:
ABT 263
Synonyms
ABT 263;Navitoclax;Navitoclax, >=98%;ABT-263,Navitoclax;Navitoclax (ABT-263);BenzaMide, 4-(4-((2-(4-chlorophenyl)-5,5-diMe;ABT 263, 98%, potent inhibitor of Bcl-xL,Bcl-2 and Bcl-w;(S)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperaz;(R)-4-(4-((2-(4-Chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morph;(R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide
CBNumber:
CB21872884
Molecular Formula:
C47H55ClF3N5O6S3
Formula Weight:
974.61
MOL File:
923564-51-6.mol

ABT 263 Properties

Melting point:
114-116°C
storage temp. 
-20°C Freezer, Under Inert Atmosphere
CAS DataBase Reference
923564-51-6
SAFETY
  • Risk and Safety Statements
HS Code  29339900

ABT 263 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11500 ABT-263 ≥98% 923564-51-6 1mg $35 2018-11-13 Buy
Cayman Chemical 11500 ABT-263 ≥98% 923564-51-6 5mg $109 2018-11-13 Buy
Cayman Chemical 11500 ABT-263 ≥98% 923564-51-6 10mg $179 2018-11-13 Buy
Cayman Chemical 11500 ABT-263 ≥98% 923564-51-6 25mg $350 2018-11-13 Buy

ABT 263 Chemical Properties,Uses,Production

Description

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2.

In vitro

ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263.

Chemical Properties

Pale Yellow Solid

Uses

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.

Uses

A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate.

ABT 263 Preparation Products And Raw materials

Raw materials

Preparation Products


ABT 263 Suppliers

Global( 134)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21752 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2289 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 306 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23976 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58

View Lastest Price from ABT 263 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 ABT 263
923564-51-6
US $2.00 / KG 1KG 99% customise career henan chemical co

923564-51-6(ABT 263)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved