ACLARUBICIN HYDROCHLORIDE
- CAS No.
- 75443-99-1
- Chemical Name:
- ACLARUBICIN HYDROCHLORIDE
- Synonyms
- aclacinon;Aclarubicin HCl;Aclarubicin hydrochlride;ACLARUBICIN HYDROCHLORIDE;aclacinomycinahydrochloride;ACLARUBICIN HYDROCHLORIDE USP/EP/BP;Aclarubicin hydrochloride (Aclacinomycin A);syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
- CBNumber:
- CB2189954
- Molecular Formula:
- C42H54ClNO15
- Molecular Weight:
- 848.33
- MDL Number:
- MFCD00133024
- MOL File:
- 75443-99-1.mol
- MSDS File:
- SDS
Melting point | 151-153℃ |
---|---|
Boiling point | 898℃ |
Flash point | >110°(230°F) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO or DMF at 25mg/ml |
form | Solid |
color | Light yellow to yellow |
FDA UNII | 501948RI66 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS06 |
---|---|
Hazard statements | H301-H311-H331 |
Precautionary statements | P261-P280h-P301+P310a-P304+P340-P405-P501a |
Hazard Codes | T |
Risk Statements | 23/24/25 |
Safety Statements | 36/37/39-45 |
RIDADR | 3249 |
RTECS | QI9283500 |
HazardClass | 6.1(a) |
PackingGroup | II |
ACLARUBICIN HYDROCHLORIDE price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J66842 | Aclarubicin hydrochloride, 90% | 75443-99-1 | 5mg | $124 | 2021-12-16 | Buy |
ChemScene | CS-0079483 | AclacinomycinAhydrochloride 98.08% | 75443-99-1 | 5mg | $280 | 2021-12-16 | Buy |
ChemScene | CS-0079483 | AclacinomycinAhydrochloride 98.08% | 75443-99-1 | 10mg | $480 | 2021-12-16 | Buy |
ChemScene | CS-0079483 | AclacinomycinAhydrochloride 98.08% | 75443-99-1 | 25mg | $980 | 2021-12-16 | Buy |
AK Scientific | 0647CB | Aclarubicinhydrochloride | 75443-99-1 | 10mg | $1197 | 2021-12-16 | Buy |
ACLARUBICIN HYDROCHLORIDE Chemical Properties,Uses,Production
Definition
ChEBI: Aclarubicin hydrochloride is an anthracycline.
Biological Activity
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) is a fluorescent molecule and the first non-peptidic inhibitor discovered to have discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. It is also a dual inhibitor of topoisomerase I and II (topoisomerase I and II). It is an effective anthracycline chemotherapeutic agent for blood cancer and solid tumor related research.
in vitro
Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .
in vivo
Aclarubicin hydrochloride(Aclacinomycin A) is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A ( 0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .
Animal Model: | DBA/2, CDF 1 ( BALB/c×DBA/2) mice with Leukemia P-388 [4 . | tr>
Dosage: | 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg. | td>
Administration: | Intraperit oneal administration daily for 10 days starting 3 hr after transplantation. |
Result: | Inhibited tumor growth. |
target
20S proteasome.
Topoisomerase I and II.
ACLARUBICIN HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ACLARUBICIN HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22787 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
View Lastest Price from ACLARUBICIN HYDROCHLORIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2021-07-02 | ACLARUBICIN HYDROCHLORIDE USP/EP/BP
75443-99-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
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2020-05-03 | Aclarubicin Hydrochloride
75443-99-1
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd |
-
- ACLARUBICIN HYDROCHLORIDE USP/EP/BP
75443-99-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Aclarubicin Hydrochloride
75443-99-1
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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