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ACLARUBICIN HYDROCHLORIDE

ACLARUBICIN HYDROCHLORIDE Structure
ACLARUBICIN HYDROCHLORIDE structure
CAS No.
75443-99-1
Chemical Name:
ACLARUBICIN HYDROCHLORIDE
Synonyms
aclacinon;Aclarubicin HCl;Aclarubicin hydrochlride;ACLARUBICIN HYDROCHLORIDE;aclacinomycinahydrochloride;ACLARUBICIN HYDROCHLORIDE USP/EP/BP;Aclarubicin hydrochloride (Aclacinomycin A);syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4;n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano;1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo
CBNumber:
CB2189954
Molecular Formula:
C42H54ClNO15
Molecular Weight:
848.33
MDL Number:
MFCD00133024
MOL File:
75443-99-1.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:17
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ACLARUBICIN HYDROCHLORIDE Properties

Melting point 151-153℃
Boiling point 898℃
Flash point >110°(230°F)
storage temp. 2-8°C
solubility Soluble in DMSO or DMF at 25mg/ml
FDA UNII 501948RI66

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Hazard statements  H301-H311-H331
Precautionary statements  P261-P280h-P301+P310a-P304+P340-P405-P501a
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  36/37/39-45
RIDADR  3249
RTECS  QI9283500
HazardClass  6.1(a)
PackingGroup  II

ACLARUBICIN HYDROCHLORIDE price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J66842 Aclarubicin hydrochloride, 90% 75443-99-1 5mg $124 2021-12-16 Buy
ChemScene CS-0079483 AclacinomycinAhydrochloride 98.08% 75443-99-1 5mg $280 2021-12-16 Buy
ChemScene CS-0079483 AclacinomycinAhydrochloride 98.08% 75443-99-1 10mg $480 2021-12-16 Buy
ChemScene CS-0079483 AclacinomycinAhydrochloride 98.08% 75443-99-1 25mg $980 2021-12-16 Buy
AK Scientific 0647CB Aclarubicinhydrochloride 75443-99-1 10mg $1197 2021-12-16 Buy
Product number Packaging Price Buy
J66842 5mg $124 Buy
CS-0079483 5mg $280 Buy
CS-0079483 10mg $480 Buy
CS-0079483 25mg $980 Buy
0647CB 10mg $1197 Buy

ACLARUBICIN HYDROCHLORIDE Chemical Properties,Uses,Production

Definition

ChEBI: Aclarubicin hydrochloride is an anthracycline.

Biological Activity

Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) is a fluorescent molecule and the first non-peptidic inhibitor discovered to have discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. It is also a dual inhibitor of topoisomerase I and II (topoisomerase I and II). It is an effective anthracycline chemotherapeutic agent for blood cancer and solid tumor related research.

in vitro

Aclacinomycin A could efficiently enter living cells and emit fluorescence in situ . Aclacinomycin A (10 μM for 15 min) is sufficient for clear detection of fluorescence in most of the cultured cells. Aclacinomycin A treatment (10 μM Acla for 15 min) results in approximately 20% dead (or nearly dead) cells.
Aclacinomycin A (Aclarubicin) effectively induces incorporation of exon 7 into SMN2 transcripts from the endogenous gene in type I SMA fibroblasts as well as into transcripts from a SMN2 minigene in the motor neuron cell line NSC34 .

in vivo

Aclarubicin hydrochloride(Aclacinomycin A) is very well absorbed in mice, rats, and dogs after its oral administration. The oral LD 50 (76.5 mg/kg) is about twice the iv LD 50 (35.6 mg/kg) in mice [4 .
Aclacinomycin A ( 0.75-6 mg/kg, ip daily) dose-dependently exhibits tumor growth in mice-based Leukemia P-388 model [4 .

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Animal Model: DBA/2, CDF 1 ( BALB/c×DBA/2) mice with Leukemia P-388 [4 .
Dosage: 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg.
Administration: Intraperit oneal administration daily for 10 days starting 3 hr after transplantation.
Result: Inhibited tumor growth.

target

20S proteasome.
Topoisomerase I and II.

ACLARUBICIN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

ACLARUBICIN HYDROCHLORIDE Suppliers

Global( 40)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 15319487004 1015@dideu.com China 2263 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29322 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33349 58
Shanghai Fuhe Chemistry Technology Co., Ltd. 0086-21-67651709 cfx759@hotmail.com China 410 57
Supplier Advantage
BOC Sciences 		58
Shaanxi Dideu Medichem Co. Ltd 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
Alfa Chemistry 		58
InvivoChem 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Shanghai Fuhe Chemistry Technology Co., Ltd. 57

View Lastest Price from ACLARUBICIN HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ACLARUBICIN HYDROCHLORIDE USP/EP/BP pictures 2021-07-02 ACLARUBICIN HYDROCHLORIDE USP/EP/BP
75443-99-1
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Aclarubicin Hydrochloride pictures 2020-05-03 Aclarubicin Hydrochloride
75443-99-1
 US $0.00-0.00 / Kg 1KG 99.0% 800 ton Shaanxi Dideu Medichem Co. Ltd

75443-99-1(ACLARUBICIN HYDROCHLORIDE)Related Search:

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1,2,3,4-Tetrahydro-1-naphthoic acid 2-HYDROXY-5-METHYLBENZOPHENONE (S)-(+)-1,2,3,4-Tetrahydro-1-naphthol Methyl salicylate 3-BENZOYLPHENYLACETIC ACID
2-Amylanthraquinone 3-METHOXYETHOXYPROPYLAMINE Aclarubicin 5-(4-METHYLPHENYL)VALERIC ACID (2RS)-2-(4-ETHYLPHENYL)PROPANOIC ACID
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aclacinomycinahydrochloride aclacinon n-2-yl)-alpha-l-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-l-lyxo-hexopyrano syl)oxy)-2,5,7-trihydroxy-,methylester,hydrochloride,(1r-(1-alpha,2-beta,4 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-l-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-l-lyxo ACLARUBICIN HYDROCHLORIDE 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, meth 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-, methyl ester, hydrochloride, [1R-(1α,2β,4β)]- Aclarubicin hydrochlride Aclarubicin HCl Aclarubicin hydrochloride (Aclacinomycin A) ACLARUBICIN HYDROCHLORIDE USP/EP/BP methyl(1R,2R,4S)-4-[(2R,4S,5S,6S)-4-(dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,6S)-6-methyl-5-oxooxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-3,4-dihydro-1H-tetracene-1-carboxylate,hydrochloride 75443-99-1 C42H54ClNO15 C42H53NO15HCl API