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Cilnidipine

Description References
Cilnidipine
Cilnidipine structure
CAS No.
132203-70-4
Chemical Name:
Cilnidipine
Synonyms
ATELEC;SISCARD;FRG 8653;CINALONG;FRC-8653;CILNIDPINE;Cinidipine;CINILDPINE;CILNDIPINE;ilnidipine
CBNumber:
CB2193117
Molecular Formula:
C27H28N2O7
Formula Weight:
492.52
MOL File:
132203-70-4.mol

Cilnidipine Properties

Melting point:
97-99°C
storage temp. 
Store at +4°C
solubility 
H2O: ≤2mg/mL
form 
powder
color 
light yellow
Merck 
14,2275
InChIKey
KJEBULYHNRNJTE-DHZHZOJOSA-N
CAS DataBase Reference
132203-70-4(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  41
Safety Statements  26-39
WGK Germany  3
RTECS  US7975550
HS Code  29333990
Toxicity LD50 in male, female mice, rats (mg/kg): 5000, 5000, 5000, 4412 orally; 5000 all species s.c.; 1845, 2353, 441, 426 i.p. (Wada)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Cilnidipine price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C1493 Cilnidipine ≥98% (HPLC), powder 132203-70-4 10mg $134 2018-11-13 Buy
Sigma-Aldrich C1493 Cilnidipine ≥98% (HPLC), powder 132203-70-4 50mg $538 2018-11-13 Buy
TCI Chemical C2564 Cilnidipine >98.0%(HPLC) 132203-70-4 1g $99 2018-11-22 Buy
TCI Chemical C2564 Cilnidipine >98.0%(HPLC) 132203-70-4 5g $305 2018-11-22 Buy
Cayman Chemical 26080 Cilnidipine ≥98% 132203-70-4 500mg $55 2018-11-19 Buy

Cilnidipine Chemical Properties,Uses,Production

Description

Clinidipine is a kind of calcium channel blocker. It is a kind of novel calcium antagonist with the blocking effect on both L-type and N-type calcium channels. It is mainly used for the treatment of hypertension. Based on its effect on both N-type and L-type calcium channel, it can dilate both arterioles and venules, further reducing the pressure in the capillary bed. In addition, cilinidipine can attenuate the platelet activation associated with catecholamines.

References

https://www.drugbank.ca/drugs/DB09232
https://en.wikipedia.org/wiki/Cilnidipine

Description

Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.

Chemical Properties

Yellow Crystalline Solid

Originator

Fujirebio (Japan)

Uses

A dihydropyridine calcium channel blocker

Uses

antihypertensive;dihydropyridine calcium channel blocker

Definition

ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.

brand name

Cinalong;Siscard;Atelec

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Cilnidipine Preparation Products And Raw materials

Raw materials

Preparation Products


Cilnidipine Suppliers

Global( 226)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Hebei Jiangkai Trading Co., Ltd
0086-17197824289/17197824028
alice@hbjkai.com CHINA 274 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 615 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 309 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 925 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20331 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 1020 58

View Lastest Price from Cilnidipine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-11 Cilnidipine
132203-70-4
US $1.00 / kg 1kg 99% 500KG Hebei Jimi Trading Co., Ltd.
2018-08-20 Cilnidipine
132203-70-4
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-26 Cilnidipine
132203-70-4
US $100.00 / KG 1KG 98% 100KG career henan chemical co

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