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Cefotaxime sodium

Brand Name(s) in US
Cefotaxime sodium
Cefotaxime sodium structure
CAS No.
64485-93-4
Chemical Name:
Cefotaxime sodium
Synonyms
ctx;hr756;Pretor;FIR-756;ru24756;Cefotax;Chemcef;Tolycar;CLAFORAN;Cefotaxime Na
CBNumber:
CB2197478
Molecular Formula:
C16H16N5NaO7S2
Formula Weight:
477.45
MOL File:
64485-93-4.mol

Cefotaxime sodium Properties

Melting point:
162-163 C
alpha 
D20 +55±2° (c = 0.8 in water)
refractive index 
61 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
form 
powder
color 
white to yellow
PH
pH(100g/l, 25℃) : 4.5~6.5
Water Solubility 
Soluble in water.
Merck 
14,1933
BRN 
5711411
Stability:
Stable. Incompatible with strong oxidizing agents.
FDA UNII
258J72S7TZ
NCI Dictionary of Cancer Terms
CTX
NCI Drug Dictionary
Claforan
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P284-P304+P340-P342+P311-P280g-P342+P311a-P501a
Hazard Codes  Xn,Xi
Risk Statements  42/43
Safety Statements  22-36/37-60-45-37-24
WGK Germany  2
RTECS  XI0250000
HS Code  29419000

Cefotaxime sodium price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2099 Cefotaxime Sodium Pharmaceutical Secondary Standard; Certified Reference Material 64485-93-4 1 g $120 2021-03-22 Buy
Sigma-Aldrich 1097909 Cefotaxime sodium United States Pharmacopeia (USP) Reference Standard 64485-93-4 500mg $144 2020-08-18 Buy
Sigma-Aldrich C0685000 Cefotaxime sodium European Pharmacopoeia (EP) Reference Standard 64485-93-4 $190 2021-03-22 Buy
Sigma-Aldrich Y0000506 Cefotaxime for peak identification European Pharmacopoeia (EP) Reference Standard 64485-93-4 $190 2021-03-22 Buy
Sigma-Aldrich C7039 Cefotaxime sodium salt plant cell culture tested, BioReagent, powder 64485-93-4 1g $242 2021-03-22 Buy

Cefotaxime sodium Chemical Properties,Uses,Production

Brand Name(s) in US

Claforan

Chemical Properties

White to pale yellow crystalline powder

Originator

Claforan,Hoechst-Roussel,W. Germany,1980

Uses

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group

Uses

Cephalosporin antibacterial

Definition

ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.

Manufacturing Process

A solution of 8 g of sodium bicarbonate in about 20 ml of ethanol was progressively added to 45.55 g of pure 3-acetoxymethyl-7-[2-(2-amino-4- thiazolyl)-2-methoxyiminoacetamido]-ceph-3-eme-4-carboxylic acid in 100 ml of distilled water and another 80 ml of ethanol and 4.5 g of activated carbon were added thereto. The mixture was stirred for 5 minutes and was filtered. The filter was rinsed with ethanol and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in 100 ml of ethanol and evaporated to dryness again. The residue was dissolved in 100 ml of methanol and the solution was poured into 2 l of acetone. The mixture was vigorously stirred and was vacuum filtered. The recovered product was rinsed with acetone and then ether and dried under reduced pressure to obtain 43.7 g of a white product which rehydrated in air to obtain a final weight of 45.2 g of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2- methoxyiminoacetamido]-ceph-3-eme-4-carboxylate.

brand name

Claforan (Sanofi Aventis).

Therapeutic Function

Antibiotic

Clinical Use

Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.
The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.

Veterinary Drugs and Treatments

In the United States, there are no cefotaxime products approved for veterinary species but it has been used clinically in several species when an injectable 3rd generation cephalosporin may be indicated.

Cefotaxime sodium Preparation Products And Raw materials

Raw materials

Preparation Products


Cefotaxime sodium Suppliers

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View Lastest Price from Cefotaxime sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Cefotaxime sodium
64485-93-4
US $78.00-65.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-20 Cefotaxime Sodium
64485-93-4
US $50.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-20 hot selling Cefotaxime Sodium
64485-93-4
US $50.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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