2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
- CAS No.
- 478482-75-6
- Chemical Name:
- 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE
- Synonyms
- TIBPO;GSK3β Inhibitor II;GSK-3 INHIBITOR II;GSK3.beta. Inhibitor II;GLYCOGEN SYNTHASE KINASE-3 INHIBITOR II;GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem;2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE;2-((3-Iodobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole;4-[5-[[(3-Iodophenyl)methyl]thio]-1,3,4-oxadiazol-2-yl]pyridine;2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
- CBNumber:
- CB2201711
- Molecular Formula:
- C14H10IN3OS
- Molecular Weight:
- 395.22
- MDL Number:
- MFCD04974171
- MOL File:
- Mol file
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 361541 | GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem | 478482-75-6 | 5mg | $141 | 2021-12-16 | Buy |
Cayman Chemical | 19077 | GSK3β Inhibitor II ≥95% | 478482-75-6 | 5mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 19077 | GSK3β Inhibitor II ≥95% | 478482-75-6 | 10mg | $176 | 2024-03-01 | Buy |
ApexBio Technology | C4599 | GSK-3βInhibitorII | 478482-75-6 | 10mg | $198 | 2021-12-16 | Buy |
AK Scientific | 9903CP | GSK-3InhibitorII | 478482-75-6 | 5mg | $201 | 2021-12-16 | Buy |
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Chemical Properties,Uses,Production
Definition
ChEBI: 2-[(3-iodophenyl)methylthio]-5-pyridin-4-yl-1,3,4-oxadiazole is an aryl sulfide.
Biological Activity
gsk-3β inhibitor ii is a gsk-3β inhibitor.glycogen synthase kinase-3 (gsk-3), a protein-serine kinase, is implicated in the hormonal control of various regulatory proteins. a number of substrates have been identified, which implicates gsk-3 in the regulation of several physiological processes. moreover, it has been reported that compounds that specifically inhibit gsk-3 activity may be useful in the treatment of diabetes.
in vitro
in a previous study, by using a virtual screening strategy based on a methodology derived from the cats molecular descriptor, a novel compound class including gsk-3β inhibitor ii with inhibitory activity against the gsk-3 enzyme was identified via scaffold hopping. gsk-3β inhibitor ii was found to be a potent inhibitor of gsk-3β with the ic50 value of 390 nm. however, gsk-3β inhibitor ii was not able to inhibit another gsk-3 isoform, gsk-3α [1]. another study found that gsk-3β inhibitor ii could block the functional regulation of p53 through inhibiting gsk-3β, decreasing mdm2 levels, and modulating mitochondrial p53 apoptotic signaling [2].
IC 50
390 nm for gsk-3β
References
[1] naerum, l. ,nrskov-lauritsen, l. and olesen, p.h. scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors. bioorg.med.chem.lett. 12(11), 1525-1528 (2002).
[2] watcharasit, p. ,bijur, g.n.,song, l., et al. glycogen synthase kinase-3beta (gsk3beta) binds to and promotes the actions of p53. j.biol.chem. 278(49), 49972-48879 (2003).
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9900 | 58 | |
Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 1004 | 55 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4182 | 55 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9945 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |