Homosalate
- CAS No.
- 118-56-9
- Chemical Name:
- Homosalate
- Synonyms
- HMS;HOMOMENTHYL SALICYLATE;Heliopan;Homosalat;3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE;Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester;HELIOPHAN;omosalate;HOMOSALATE;Coppertone
- CBNumber:
- CB2203124
- Molecular Formula:
- C16H22O3
- Molecular Weight:
- 262.34
- MDL Number:
- MFCD00019377
- MOL File:
- 118-56-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Homosalate Pharmaceutical Secondary Standard; Certified Reference Material | PHR1085 | 1g | $110 |
| 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE AldrichCPR | S356662 | 1 unit | $191 |
| Homosalate United States Pharmacopeia (USP) Reference Standard | 1311408 | 500mg | $422 |
| 3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture) >98.0%(GC) | T2278 | 25g | $43 |
| 3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture) >98.0%(GC) | T2278 | 100g | $106 |
| More product size | |||
| Boiling point | 161-165°C (12 torr) |
|---|---|
| Density | 1.05 |
| vapor pressure | 0.015Pa at 25℃ |
| refractive index | n20 1.516 to 1.518 |
| Flash point | 169 - 173℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| form | Liquid |
| pka | 8.10±0.30(Predicted) |
| color | Colourless |
| Odor | at 100.00%. mild menthol |
| Water Solubility | <0.1 g/100 mL at 26 ºC |
| BRN | 2731604 |
| Cosmetics Ingredients Functions |
FRAGRANCE UV ABSORBER UV FILTER |
| LogP | 6.27 at 25℃ |
| CAS DataBase Reference | 118-56-9(CAS DataBase Reference) |
| FDA 21 CFR | 352.70 |
| EWG's Food Scores | 2-4 |
| FDA UNII | V06SV4M95S |
| NIST Chemistry Reference | Homosalate(118-56-9) |
| EPA Substance Registry System | 3,3,5-Trimethylcyclohexyl salicylate (118-56-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/39 | |||||||||
| WGK Germany | 2 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29182300 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Homosalate price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1085 | Homosalate Pharmaceutical Secondary Standard; Certified Reference Material | 118-56-9 | 1g | $110 | 2026-04-30 | Buy |
| Sigma-Aldrich | S356662 | 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE AldrichCPR | 118-56-9 | 1 unit | $191 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1311408 | Homosalate United States Pharmacopeia (USP) Reference Standard | 118-56-9 | 500mg | $422 | 2026-04-30 | Buy |
| TCI Chemical | T2278 | 3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture) >98.0%(GC) | 118-56-9 | 25g | $43 | 2026-04-30 | Buy |
| TCI Chemical | T2278 | 3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture) >98.0%(GC) | 118-56-9 | 100g | $106 | 2026-04-30 | Buy |
Homosalate Chemical Properties,Uses,Production
Description
Homosalate is an organic compound that belongs to a class of chemicals called salicylates. Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. Homosalate specifically absorbs short-wave UVB rays, associated with DNA damage and an increased risk of skin cancer. It is a widely used chemical in sunscreens and skin care products with SPF. However, Homosalate is a potential endocrine disruptor and studies in cells suggest it may impact hormones. In addition to direct health concerns following homosalate exposure, the chemical may also enhance the absorption of pesticides in the body.
Chemical Properties
Liquid.
Uses
homosalate is a chemical uVB absorber included in the FDA’s Category I Sunscreen Chemical list. Its approved usage level is 4 to 15 percent by the FDA and 10 percent by the european union’s Cosmetic Directive.
Uses
UV screen, analgesic
Uses
Homosalate used as a UV filter in various personal skin care formulations and cosmetics.
Definition
A homolog of menthyl salicylate.
brand name
Eusolex (Rona Laboratories, Great Britain); Heliophan (Greeff).
General Description
Viscous or light yellow to slightly tan liquid or oil.
Air & Water Reactions
Homosalate will hydrolyze under basic conditions. . Insoluble in water.
Reactivity Profile
An ester and a phenol. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Fire Hazard
Homosalate is probably combustible.
Flammability and Explosibility
Non flammable
Side effects
Similar to oxybenzone, homosalate affects hormone activity once absorbed. Skin rashes, acne and skin irritation are rare side effects of the toxic chemical. Estrogen, androgen and progesterone have all been found to be disrupted when the body is exposed to homosalate.
Synthesis
116-02-9
119-36-8
118-56-9
In a 250 mL three-necked flask, 10.0 g of methyl salicylate and 23.3 g of 3,3,5-trimethylcyclohexanol were added as reaction feedstock, followed by 0.50 g of potassium carbonate as a catalyst and 0.1 g of ammonium bromide as a co-catalyst. The reaction mixture was heated to 180 °C and the reaction was continued at this temperature for 13 hours. The conversion of methyl salicylate was monitored by gas chromatography during the reaction. Upon completion of the reaction, the products were separated using a vacuum distillation unit, and the fore grade fractions were recycled. Finally, 13.98 g of 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate was obtained as a colorless liquid with a yield of 81.1%, and the purity was analyzed by gas chromatography to be greater than 99%.
References
[1] Patent: CN105541634, 2016, A. Location in patent: Paragraph 0023; 0024
Homosalate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qingdao Truelight functional Material Technology Co., Ltd. | +86-13573844393 | songjames@truelightchem.com | China | 222 | 58 |
| Wuhan BJM Pharm Inc | 027-52341919 13545198479 | sales03@benjaminpharmchem.com | China | 584 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5974 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
Related articles
- The properties and toxicity assessment of homosalate
- Homosalate (HMS) is an ultraviolet (UV) filtering agent used in sunscreens and other cosmetics for skin protection purposes.
- Mar 21，2025
View Lastest Price from Homosalate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-12 | Homosalate
118-56-9
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-05-11 | Homosalate
118-56-9
|
US $30.00-40.00 / mg | 99.48% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-11 | Homosalate
118-56-9
|
US $30.00-40.00 / mg | 99.48% | 10g | TargetMol Chemicals Inc. |
-
- Homosalate
118-56-9
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Homosalate
118-56-9
- US $30.00-40.00 / mg
- 99.48%
- TargetMol Chemicals Inc.
-
- Homosalate
118-56-9
- US $30.00-40.00 / mg
- 99.48%
- TargetMol Chemicals Inc.
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