Cinobufagin
- CAS No.
- 470-37-1
- Chemical Name:
- Cinobufagin
- Synonyms
- FEMA 2288;AKOS 233-01;CINOBUFAGIN;16-beta)-bet;cinobufagine;AKOS B004228;CINOBUFAGIN(P);Cinobufagin std.;Cinobufagin (6CI);Chinese bufotoxin
- CBNumber:
- CB2206701
- Molecular Formula:
- C26H34O6
- Molecular Weight:
- 442.55
- MDL Number:
- MFCD00056825
- MOL File:
- 470-37-1.mol
| Melting point | 133 °C(lit.) |
|---|---|
| Boiling point | 300 °C(lit.) |
| Density | 1.261 g/cm3 |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml |
| form | powder to crystal |
| pka | 15.10±0.70(Predicted) |
| color | White to Light yellow |
| FDA UNII | T9PSN4R8IR |
| NCI Drug Dictionary | cinobufagin |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H310-H330 | |||||||||
| Precautionary statements | P260-P264-P280-P284-P302+P350-P310 | |||||||||
| Hazard Codes | Xi,T+,Xn | |||||||||
| Risk Statements | 36/37/38-26/27/28-42/43-20/22 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22-24/25 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD7850000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29322090 | |||||||||
| NFPA 704 |
|
Cinobufagin price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3460 | Cinobufagine >98.0%(HPLC) | 470-37-1 | 25mg | $304 | 2024-03-01 | Buy |
| TCI Chemical | C3460 | Cinobufagine >98.0%(HPLC) | 470-37-1 | 100mg | $908 | 2024-03-01 | Buy |
| Cayman Chemical | 19844 | Cinobufagin | 470-37-1 | 5mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 19844 | Cinobufagin | 470-37-1 | 50mg | $566 | 2024-03-01 | Buy |
| Cayman Chemical | 19844 | Cinobufagin | 470-37-1 | 10mg | $206 | 2024-03-01 | Buy |
Cinobufagin Chemical Properties,Uses,Production
Description
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.
References
1. https://en.wikipedia.org/wiki/Cinobufagin
2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
3. http://www.yourdictionary.com/cinobufagin
4. https://www.medchemexpress.com/cinobufagin.html
Description
Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.
Uses
Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Definition
ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.
Cinobufagin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
View Lastest Price from Cinobufagin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Cinobufagin
470-37-1
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-24 | Cinobufagin
470-37-1
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2021-07-02 | Cinobufagin
470-37-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Cinobufagin
470-37-1
- US $0.00 / mg
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.
-
- Cinobufagin
470-37-1
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Cinobufagin
470-37-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd