ChemicalBook >> CAS DataBase List >>(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester structure

CAS No.: 149809-43-8

Chemical Name:: (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

Synonyms: (5R-cis)-Toluene-4-sulfonic acid;((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Posaconazole A;Posaconazole int1;((3S,5R)-5-((1H-1;US-DMF No.: 033193;Posaconazole inter-1;Posaconazole Main Ring;Posaconazole 149809-43-8

CBNumber:: CB22128616

Molecular Formula:: C21H21F2N3O4S

Molecular Weight:: 449.47

MDL Number:: MFCD13195567

MOL File:: 149809-43-8.mol

MSDS File:: SDS

Last updated:2024-04-22 13:10:39

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(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Properties

Melting point	100-102°C
Boiling point	608.1±65.0 °C(Predicted)
Density	1.40
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	slightly sol. in Chloroform
form	powder to crystal
pka	2.75±0.10(Predicted)
color	White to Orange to Green
InChIKey	DFWVLCJRFGIRAK-HRAATJIYSA-N
CAS DataBase Reference	149809-43-8(CAS DataBase Reference)
FDA UNII	LDY4QZP8PB

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H311-H331-H341
Precautionary statements	P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
HS Code	2934.99.4400

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4537	(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate >98.0%(HPLC)	149809-43-8	1g	$457	2021-12-16	Buy
TCI Chemical	D4537	(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate >98.0%(HPLC)	149809-43-8	200mg	$123	2024-03-01	Buy
TRC	T535900	(5R-cis)-Toluene-4-sulfonicAcid5-(2,4-Difluorophenyl)-5-[1,2,4]triazol-1-ylmethyltetrahydrofuran-3-ylmethylEster	149809-43-8	100mg	$790	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0029265	(5R-CIS)-TOLUENE-4-SULFONIC ACID 5-(2,4-DIFLUOROPHENYL)-5-(1H-1,2,4-TRIAZOL-1-YL)METHYLTETRAHYDROFURAN-3-YLMETHYL ESTER 95.00%	149809-43-8	100MG	$1709.98	2021-12-16	Buy
Ark Pharm	P000097815	((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate 97%	149809-43-8	5g	$553	2021-12-16	Buy

Product number	Packaging	Price	Buy
D4537	1g	$457	Buy
D4537	200mg	$123	Buy
T535900	100mg	$790	Buy
HCH0029265	100MG	$1709.98	Buy
P000097815	5g	$553	Buy

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Chemical Properties,Uses,Production

Description

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a pharmaceutical intermediate ingredient for Posaconazole is one of the newest triazole antifungal agents approved by the FDA for the prevention of invasive Aspergillus and Candida infections in immunocompromised patients. Such patients include haematopoietic stem cell transplant patients with graft-versus-host disease and patients with haematological malignancies undergoing chemotherapy.

Chemical Properties

White Crystalline Solid

Uses

Posaconazole intermediate. Antifungal agent.

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester synthesis

Synthesis of (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester from Tosyl chloride and D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)-

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Preparation Products And Raw materials

Raw materials

Toluene-4-sulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl Tosyl chloride

Preparation Products

O-Benzyl Posaconazole

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Suppliers

Global( 379)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	+86-010-83386758 +86-18810831598	jennifer@lianben.com	China	85	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	925	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	283	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58

Supplier	Advantage
Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Hangzhou Cyanochem Co., Ltd.	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-28	(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester 149809-43-8	US $0.00 / kg	25kg	98%	Inquiry	PNP Biotech Co. Ltd
2022-11-29	(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester 149809-43-8	US $0.00-0.00 / g	1g	≥98%	1-1000	Changzhou Rokechem Technology Co., Ltd.
2022-11-03	main intermediate of Posaconazole 149809-43-8	US $0.00 / kg	25kg	99%	20 tons	TAIZHOU DKD CHEMICAL CO., LTD.

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
149809-43-8
US $0.00 / kg
98%
PNP Biotech Co. Ltd

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
149809-43-8
US $0.00-0.00 / g
≥98%
Changzhou Rokechem Technology Co., Ltd.

main intermediate of Posaconazole
149809-43-8
US $0.00 / kg
99%
TAIZHOU DKD CHEMICAL CO., LTD.

149809-43-8((5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester)Related Search:

Folic acid Citric acid 5-Methyl-1H-benzotriazole Ethyl 2-(Chlorosulfonyl)acetate 1,2,4-Triazole

Voriconazole Posaconazole 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one, 1H-Benzotriazole Ribavirin

D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)- Ascoric Acid Posaconazole Impurity 44 Posaconazole Impurity 17 Posaconazole iMpurity 4

Posaconazole DiastereoisoMer interMediate 2 PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE Posaconazole inter-8

1of4

((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate Posaconazole InterMediates (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester- (POA) (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4 Toluene-4-sulfonica cid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester Posaconazole InterMediate Posaconazole inter-1 Posaconazole Main Ring (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate Posaconazole int1 Posaconazole Intermediate1 Posa-12 ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl 4-methylbenzenesulfonate ((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)methyl (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Posaconazole Tosyl Impurity (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate > (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydr D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-(1H-1,2,4-triazol-1-yl)- (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl) ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate (Posaconazole intermediate) Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester p-Toluenesulfonic Acid (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl Ester Posaconazole 149809-43-8 (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester ISO 9001：2015 REACH Posaconazole main compound 1 (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1... ((3S,5R)-5-((1H-1 US-DMF No.: 033193 (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofur ((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-Toluene benzenesulfonate (5R-cis)-Toluene-4-sulfonic acid 5-(2 4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester 4-difluorophenyl)-5-(1H-1 4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl esterChemicalBook Posaconazole Diastereoisomer Related Compound 8 ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluo (5R-CIS) -Toluene-4-sulfonic acid 5- (2,4-difluorophenyl) -5- (1H-1,2,4-triazol-1-yl) methyl tetrahydrofuran-3- Methyl ester (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl esterChemicalBook [(3S,5R)-5-(2,4-difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-yl]methyl 4-methylbenzene-1-sulfonate Posazonazole intermediate POA Posaconazole Impurity 53 2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol ((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate (5R-cis)-Toluene-4-sulfonic acid (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazo 1-yl)methyltetrahydrofuran-3-ylmethyl ester ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)methyl 4- (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methy... main intermediate of Posaconazole Posaconazole A (3S,5R)-5-(1,2,4-triazol-1-yl-methyl)-5-(2,4-difluorophenyl)-3-(tosyloxymethyl)tetrahydrofuran Posaconazole Intermediate-A 149809-43-8 C21H21F2N3O4S Aromatics Chiral Reagents Intermediates Intermediates & Fine Chemicals