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Fimasartan

Fimasartan Structure
Fimasartan structure
CAS No.
247257-48-3
Chemical Name:
Fimasartan
Synonyms
Kanarb;BR-A-657;Fimasartan;Fimasartan D4;Unii-p58222188p;KANARB; BR-A-657;Fimasartan(BR-A-657);FiMasartan USP/EP/BP;Fimasartan Impurity H;2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim
CBNumber:
CB22128722
Molecular Formula:
C27H31N7OS
Molecular Weight:
501.65
MDL Number:
MFCD13194795
MOL File:
247257-48-3.mol
MSDS File:
SDS
Last updated:2023-12-08 14:33:09
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Fimasartan Properties

Melting point >155°C (dec.)
Boiling point 693.0±65.0 °C(Predicted)
Density 1.25
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 4.16±0.10(Predicted)
color White to Off-White
FDA UNII P58222188P
ATC code C09CA10

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Fimasartan price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3256 Fimasartan ≥98% (HPLC) 247257-48-3 10MG $86.5 2024-03-01 Buy
Sigma-Aldrich SML3256 Fimasartan ≥98% (HPLC) 247257-48-3 50MG $280 2024-03-01 Buy
TRC F342040 Fimasartan 247257-48-3 25mg $120 2021-12-16 Buy
Usbiological 450068 Fimasartan 247257-48-3 5mg $312 2021-12-16 Buy
AK Scientific 1904AB 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide 247257-48-3 100mg $383 2021-12-16 Buy
Product number Packaging Price Buy
SML3256 10MG $86.5 Buy
SML3256 50MG $280 Buy
F342040 25mg $120 Buy
450068 5mg $312 Buy
1904AB 100mg $383 Buy

Fimasartan Chemical Properties,Uses,Production

Description

Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name Kanarb by Boryung Pharmaceuticals.

Uses

Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.

Definition

ChEBI: Fimasartan is a member of biphenyls.

Biological Activity

Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

Mechanism of action

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

Fimasartan synthesis

1361024-52-3
247257-48-3
Synthesis of Fimasartan from 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide

Fimasartan Preparation Products And Raw materials

Raw materials

2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide

Preparation Products

Fimasartan Suppliers

Global( 173)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd
+8618928027945 sales3@zhhairuide.com China 97 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12457 58
Zibo Wei Bin Import & Export Trade Co. Ltd. 		+86-0533-2091136 +8613864437655 ziboweibinmaoyi@163.com China 100 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Supplier Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
Zibo Wei Bin Import & Export Trade Co. Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
BOC Sciences 		58

Related articles

View Lastest Price from Fimasartan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fimasartan pictures 2024-04-07 Fimasartan
247257-48-3
 US $0.00 / kg 0.1kg 98% 30kg Zibo Wei Bin Import & Export Trade Co. Ltd.
Fimasartan pictures 2023-09-08 Fimasartan
247257-48-3
 US $0.00 / KG Ton 1KG Ton 99.5%+ 2 tons/month Zhuhai Hairuide Bioscience and Technology Co., Ltd
Fimasartan pictures 2023-08-05 Fimasartan
247257-48-3
 US $0.00 / kg 1kg 99% 1000tons Hebei Mojin Biotechnology Co., Ltd
  • Fimasartan pictures
  • Fimasartan
    247257-48-3
  • US $0.00 / kg
  • 98%
  • Zibo Wei Bin Import & Export Trade Co. Ltd.
  • Fimasartan pictures
  • Fimasartan
    247257-48-3
  • US $0.00 / KG Ton
  • 99.5%+
  • Zhuhai Hairuide Bioscience and Technology Co., Ltd
  • Fimasartan pictures
  • Fimasartan
    247257-48-3
  • US $0.00 / kg
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd

247257-48-3(Fimasartan)Related Search:

(S)-Indacaterol 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide Pyrazine Thiophanate-methyl Methyl acetate
Bensulfuron methyl METSULFURON METHYL tert-Butyldimethylsilyl chloride Methyl acrylate Dithiooxamide
Methylparaben N-(n-Butyl)thiophosphoric triamide Kresoxim-methyl Methyl 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide
2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide METHYL TRIPHENYLMETHYL ETHER 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

1of4

2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one Fimasartan Unii-p58222188p 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide 2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide BR-A-657 Kanarb 5-PyriMidineethanethioaMide,2-butyl-1,6-dihydro-N,N,4-triMethyl-6-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]- Fimasartan(BR-A-657) 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide Fimasartan Impurity H KANARB; BR-A-657 2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide 2-(2-butyl-4-methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[ 1,1'-biphenyl]-4-yl)methoxy)pyrimidin-5-yl)-N,N- dimethylacetamide FiMasartan USP/EP/BP 2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)- 4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)- N,N-dimethylethanethioamide Fimasartan D4 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl] methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (Fimasartan) 2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide 247257-48-3 C27H31N7OS Inhibitors API