Methyl 3-aminocrotonate
- CAS No.
- 14205-39-1
- Chemical Name:
- Methyl 3-aminocrotonate
- Synonyms
- Methyl (Z)-3-Aminobut-2-enoate;3-Aminocrotonate;(Z)-Methyl 3-aMinobut-2-enoate;methyl (E)-3-aminobut-2-enoate;3-Amino-but-2-enoic acid methyl ester;PALO-012;Nifedipine-4;Methyl 3-aminocroton;Methyl 3-aminocrotote;Nifedipine Impurity 5
- CBNumber:
- CB2222855
- Molecular Formula:
- C5H9NO2
- Molecular Weight:
- 115.13
- MDL Number:
- MFCD00071534
- MOL File:
- 14205-39-1.mol
- MSDS File:
- SDS
Melting point | 81-83 °C(lit.) |
---|---|
Boiling point | 112°C 42mm |
Density | 1.1808 (rough estimate) |
vapor pressure | 2.79-2.853hPa at 25℃ |
refractive index | 1.4538 (estimate) |
Flash point | 91 °C |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | 18g/l |
pka | 5.27±0.70(Predicted) |
form | Crystalline Powder |
color | White to slightly yellow |
PH | 8-9 (18g/l, H2O, 20℃) |
Water Solubility | insoluble |
Sensitive | Hygroscopic |
BRN | 956592 |
InChIKey | XKORCTIIRYKLLG-ONEGZZNKSA-N |
LogP | -0.27 at 25℃ |
CAS DataBase Reference | 14205-39-1(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | D0M0GH0040 |
EPA Substance Registry System | 2-Butenoic acid, 3-amino-, methyl ester (14205-39-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H317-H318 | |||||||||
Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22-36/37/38 | |||||||||
Safety Statements | 37/39-26-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | EM9092500 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29224995 | |||||||||
NFPA 704 |
|
Methyl 3-aminocrotonate price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 129712 | Methyl 3-aminocrotonate 97% | 14205-39-1 | 100g | $54.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 129712 | Methyl 3-aminocrotonate 97% | 14205-39-1 | 500g | $54.8 | 2024-03-01 | Buy |
TCI Chemical | A1001 | Methyl 3-Aminocrotonate >98.0%(T) | 14205-39-1 | 25g | $16 | 2024-03-01 | Buy |
TCI Chemical | A1001 | Methyl 3-Aminocrotonate >98.0%(T) | 14205-39-1 | 500g | $90 | 2024-03-01 | Buy |
Alfa Aesar | B24953 | Methyl 3-aminocrotonate, 97% | 14205-39-1 | 500g | $95.3 | 2024-03-01 | Buy |
Methyl 3-aminocrotonate Chemical Properties,Uses,Production
Chemical Properties
Crystals, yellowish-white
Uses
Methyl 3-aminocrotonate (Methyl 3-amino-2-butenoate) was used to synthesize 4-aryl-1,4-dihydropyridines possessing potential calcium channel blocking activity.
Uses
Methyl 3-aminocrotonate is used as intermediate for the syntheses of pharmaceuticals (e.g. 1,4-dihydropyridine derivatives) as well as for the manufacture of stabilizers and plastics. Product Data Sheet
Uses
Nitrendipine (N490150) metabolite. The pharmacokinetics of Nitrendipine was studied in the rat and 6 major metabolites were identified.
Preparation
3-Aminocrotonate Esters, e.g., methyl 3- aminocrotonate [14205-39-1] (3-amino-2-butenoic acid, methyl ester) can be prepared by treatment of acetoacetates with aqueous ammonia. They are mainly used in the production of a series of the dihydropyridine-type calcium antagonists.
General Description
Methyl 3-aminocrotonate undergoes waste-free solid-state cascade reaction with crystalline ninhydrin.
Flammability and Explosibility
Not classified
Methyl 3-aminocrotonate Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HUBEI VITORCOME PHARMACEUTICAL CO.,LTD | +8615629646827 | hgsk@saikangpharm.com | China | 8 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1143 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
View Lastest Price from Methyl 3-aminocrotonate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-14 | Methyl 3-aminocrotonate
14205-39-1
|
US $0.00 / kg | 1kg | 99% | 2 ton | HUBEI VITORCOME PHARMACEUTICAL CO.,LTD | ||
2024-04-15 | Methyl 3-aminocrotonate
14205-39-1
|
US $0.00 / kg | 1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
2023-09-04 | Methyl 3-aminocrotonate
14205-39-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
- Methyl 3-aminocrotonate
14205-39-1
- US $0.00 / kg
- 99%
- HUBEI VITORCOME PHARMACEUTICAL CO.,LTD
- Methyl 3-aminocrotonate
14205-39-1
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
- Methyl 3-aminocrotonate
14205-39-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd