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Isoamyl nitrite

Antianginal drugs Cyanide poisoning antidote Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Explosive hazardous characteristics Flammability hazard characteristics Storage characteristics Extinguishing agent
Isoamyl nitrite
Isoamyl nitrite
Chemical Name:
Isoamyl nitrite
amyl;Aspiral;Vaporole;Amilnitrit;amylnitrit;NCI-C50179;Amilnitrite;Amyl nitrit;AMYL NITRITE;pentanolinitris
Molecular Formula:
Formula Weight:
MOL File:

Isoamyl nitrite Properties

Boiling point:
99 °C(lit.)
0.872 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.386(lit.)
Flash point:
50 °F
storage temp. 
Clear yellow
Water Solubility 
<0.01 g/100 mL at 18 ºC
Air & Light Sensitive
Stability Unstable. Air and light sensitive. Flammable. Forms explosive mixtures with air or oxygen. Incompatible with oxidizing agents, reducing agents.
CAS DataBase Reference
110-46-3(CAS DataBase Reference)
NIST Chemistry Reference
Amyl Nitrite(110-46-3)
EPA Substance Registry System
Nitrous acid, 3-methylbutyl ester(110-46-3)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,Xn
Risk Statements  11-20/22
Safety Statements  16-24-46
RIDADR  UN 1113 3/PG 2
WGK Germany  1
RTECS  NT0187500
HazardClass  3
PackingGroup  II
HS Code  29209090
Hazardous Substances Data 110-46-3(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Isoamyl nitrite price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 150495 Isopentyl nitrite 96% 110-46-3 5ml $30.1 2017-11-08 Buy
Sigma-Aldrich 1.01245 Isopentyl nitrite 110-46-3 1EA $160 2017-11-08 Buy
TCI Chemical I0089 Isoamyl Nitrite >95.0%(GC) 110-46-3 25mL $20 2017-11-08 Buy
TCI Chemical I0089 Isoamyl Nitrite >95.0%(GC) 110-46-3 100mL $45 2017-11-08 Buy
Alfa Aesar L13909 Isopentyl nitrite, 97%, stab. with 0.2% anhyd. sodium carbonate 110-46-3 25ml $22.4 2018-11-15 Buy

Isoamyl nitrite Chemical Properties,Uses,Production

Antianginal drugs

Light yellow transparent liquid, ether-like smell with fruity. It volatiles at room temperature, and is easy to burn. It is insoluble in water, can be mixed with alcohol, ether, chloroform or benzene arbitrary at any ratio. In case of light and air it will break down.
Isoamyl nitrite, also known as amyl nitrite, is the fastest onset, and the shortest duration of anti-anginal drugs, is a sub-short-acting nitrates vasodilator, its pharmacological effects is similar to nitroglycerin, it can directly relax vascular smooth muscle, especially for small vascular smooth muscle, make systemic vasodilation, reduce peripheral resistance, blood pressure, reduce venous return blood, reduce cardiac output, thereby reduce myocardial oxygen consumption, anti-angina and effectively stimulate sexual desire. Because of its rapid hydrolysis in the gastrointestinal tract, so this product is oral invalid, drugs used clinically are usually made on a volatile liquid pharmaceutical inhalants, rapidly absorbed in the lungs after inhalation, it can be effective less than half a minute , lasts for only 3 to 10 minutes, the anti-anginal effect nitroglycerin similar, but inhaled dose of this product is difficult to control, and the adverse reaction is large, which is its shortcomings. Because it often causes severe headache, severe hypotension and tachycardia, it is now rarely used in clinical treatment of angina and biliary colic, gradually being replaced by other nitrates.
[Adverse reactions and Precautions]
Common adverse reactions are headache, facial flushing, hypotension and reflex tachycardia ect. Isoamyl nitrite owns severe reaction than nitroglycerin.
Excessive use dosage can cause low blood pressure and heart rate, increase symptoms of angina, heart rate and blood pressure should be closely observed during intravenous drug using. Due to excessive methemoglobin poisoning, symptoms include cyanosis, breathing difficulty and other symptoms of hypoxia, intravenous injection of 1% methylene blue is used for first aid, along with oxygen , and blood transfusions.
Usinge for head trauma, brain hemorrhage, acute coronary thrombosis is banned.
Using in coronary occlusion and increased intracranial pressure is banned.

Cyanide poisoning antidote

Pharmacological effects are the same with sodium nitrite, isoamyl nitrite is also an oxidizing agent, hemoglobin is oxidized to be high iron (Fe3 +) hemoglobin combines with cyanide ions to form cyanide methemoglobin, eliminates blood free cyanide ions on cytochrome oxidase enzyme infringement, but also makes the cytochrome oxidase bound cyanide ion release, leading to the enzyme activity and tissue respiration function recovery, it should be used simultaneously with sodium thiosulfate to bind with cyanide methemoglobin to form non-toxic thiocyanate group (SCN-) and excreted, and thus play a role in the treatment of cyanide poisoning. This product is administrated by inhalation, rapidly absorbed in the lungs, displays the effects after inhalation of 10 to 30 seconds, the role lasts for 3 to 5 minutes. For emergency use, sodium nitrite is intravenous injected until the symptoms improve.
The above information is edited by the Chemicalbook of Tian Ye.

Chemical Properties

Light yellow clear liquid having a boiling point of 99 °C, the relative density is 0.871 (20/4 ℃), the refractive index is 1.3871, the flash point is 10 ℃. It is soluble with alcohol, ether, it can not dissolve in water. With fruit flavor. With volatility, it will break down in the case of light and air .


It is used in synthesizing perfumes, drugs and diazo compounds. It can be used as an oxidizing agent, solvent. Isobutyl nitrite ester is a drug that is the the fastest short-acting nitrates vasodilator. It is also used as hydrocyanic acid and its salts poisoning antidote.Vasodilators, for the treatment of angina pectoris, also it is used for cyanide poisoning; it is used in synthesizing perfumes, drugs and diazo compounds. It can be used as an oxidizing agent, solvent.

Production method

It is derived from isoamyl alcohol and sodium nitrite. According to the actual production situation, it may have a different method of operation. 1. The reaction takes place in the reaction tube, in synthetic aqueous solution of sodium nitrite, isoamyl alcohol, hydrochloric acid, respectively, are put into the high slot. First sodium nitrite solution and hydrochloric acid solution are dropped at the same rate into the synthesis pipe, when the chlorine gas bubbles in the pipe,isoamyl alcohol is slowly dropped from the top of the pipe, that is in the pipeline synthetic crude. Washed, dried, fractionated to get the products. 2. The reaction is carried out in a reaction tank of sodium nitrite, isoamyl alcohol and water are added to the reaction pot, stirring, cooling to 5 ℃, solution of hydrochloric acid is dropped. At 5 ℃ insulation for 1h, after standing hours to remove the water layer, acetate layer is washed with water, then washed with sodium carbonate solution, and then washed with water. After removing the layer of water, it is dehydrated with anhydrous sodium carbonate, filtered. The filtrate is distilled, collecting 97-99 ℃ distillate, to get isoamyl nitrite.


Flammable liquid

Toxicity grading

Highly toxic

Acute toxicity

Oral-rat LD50: 505 mg/kg; inhalation-mouse LC50: 1430 PPM/30 min

Explosive hazardous characteristics

Heating can be explosive

Flammability hazard characteristics

In the case of fire, high temperature, oxidant, it is flammable; in the case of light, heat may generate toxic nitric oxide gas.

Storage characteristics

Treasury should be ventilation, low-temperature and dry; It should be stored separately from oxidants and acids.

Extinguishing agent

Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Chemical Properties

yellow liquid




ChEBI: A nitrite ester having isopentyl as the alkyl group.

General Description

Clear yellow liquid.

Air & Water Reactions

Highly flammable. Decomposes on exposure to air and light. Insoluble in water.

Reactivity Profile

Isoamyl nitrite is an oxidizing agent but can serve as a reducing agent. Forms explosive mixtures with air or oxygen. .

Fire Hazard

Isoamyl nitrite is flammable.

Isoamyl nitrite Preparation Products And Raw materials

Raw materials

Preparation Products

Isoamyl nitrite Suppliers

Global( 189)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22128 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32764 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 1885 55
career henan chemical co
+86-371-86658258 CHINA 10011 58
Yangzhou Aoxin Chemical Co., Ltd +86-514-87754778 87754779
+86-514-87752291 China 74 66
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40399 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30308 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 China 24654 81

View Lastest Price from Isoamyl nitrite manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-16 Isoamyl nitrite
US $11.00 / KG 1KG 99% 1000KG

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