MDL-29951
- CAS No.
- 130798-51-5
- Chemical Name:
- MDL-29951
- Synonyms
- CS-1105;MDL-29951, >=98%;MDL-29951; MDL29951;2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid;2-Carboxy-4,6-dichloro-1H-indole-3-propionic acid;3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid;1H-Indole-3-propanoic acid, 2-carboxy-4,6-dichloro-;3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid;MDL-29951 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid
- CBNumber:
- CB22292210
- Molecular Formula:
- C12H9Cl2NO4
- Molecular Weight:
- 302.11
- MDL Number:
- MFCD00897722
- MOL File:
- 130798-51-5.mol
- MSDS File:
- SDS
| Melting point | 273-280℃ |
|---|---|
| Boiling point | 582.5±45.0 °C(Predicted) |
| Density | 1.657±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml). |
| form | solid |
| pka | 4.04±0.30(Predicted) |
| color | Off-white |
| Stability | Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317 |
| Precautionary statements | P280-P305+P351+P338 |
MDL-29951 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16266 | MDL 29951 ≥98% | 130798-51-5 | 500μg | $51 | 2024-03-01 | Buy |
| Cayman Chemical | 16266 | MDL 29951 ≥98% | 130798-51-5 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 16266 | MDL 29951 ≥98% | 130798-51-5 | 5mg | $202 | 2024-03-01 | Buy |
| Cayman Chemical | 16266 | MDL 29951 ≥98% | 130798-51-5 | 10mg | $354 | 2024-03-01 | Buy |
| TRC | M199790 | MDL29951 | 130798-51-5 | 25mg | $150 | 2021-12-16 | Buy |
MDL-29951 Chemical Properties,Uses,Production
Description
NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 μM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.
Uses
MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase.
References
1) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal.,?6?ra93 2) Salituro?et al. (1992)?3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem.,?35?1791
MDL-29951 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
