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Bisacodyl

Bisacodyl
Bisacodyl structure
CAS No.
603-50-9
Chemical Name:
Bisacodyl
Synonyms
laco;Bicol;LA96A;neolax;ivilax;Laxans;laxine;zetrax;nigalax;Pyrilax
CBNumber:
CB2233693
Molecular Formula:
C22H19NO4
Formula Weight:
361.39
MOL File:
603-50-9.mol

Bisacodyl Properties

Melting point:
138°C
Boiling point:
493.21°C (rough estimate)
Density 
1.2545 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids.
form 
neat
pka
4.69±0.10(Predicted)
Water Solubility 
Soluble in alcohol (slightly), ether (slightly), chloroform, and acetone. Insoluble in water.
λmax
220nm(MeOH)(lit.)
Merck 
14,1242
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
KHOITXIGCFIULA-UHFFFAOYSA-N
CAS DataBase Reference
603-50-9(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
10X0709Y6I
NCI Drug Dictionary
bisacodyl
ATC code
A06AB02,A06AB52,A06AG02
NIST Chemistry Reference
Bisacodyl(603-50-9)
EPA Substance Registry System
Phenol, 4,4'-(2-pyridinylmethylene)bis-, diacetate (ester) (603-50-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261
Hazard Codes  Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  SM8750000
TSCA  Yes
HS Code  2933399090
Toxicity LD50 orally in rats: >3 g/kg (Schmidt)

Bisacodyl price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B1390 Bisacodyl analytical standard, for drug analysis 603-50-9 10g $79.9 2021-12-16 Buy
Sigma-Aldrich B1140000 Bisacodyl European Pharmacopoeia (EP) Reference Standard 603-50-9 b1140000 $190 2021-12-16 Buy
Sigma-Aldrich B1140000 Bisacodyl European Pharmacopoeia (EP) Reference Standard 603-50-9 $190 2021-12-16 Buy
TCI Chemical B5066 Bisacodyl >98.0%(HPLC)(T) 603-50-9 5g $71 2021-12-16 Buy
TCI Chemical B5066 Bisacodyl >98.0%(HPLC)(T) 603-50-9 25g $222 2021-12-16 Buy

Bisacodyl Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Dulcolax,Boehringer Ingelheim,US,1958

Uses

Cathartic.

Uses

Stimulant laxative.

Uses

Bisacodyl is used in the inhibition of (Na+K)ATPase, the increase of mucosal PGE2, and the activation of adenyl cyclase in rat intestine studies. It is used as a laxative drug. It is typically prescribed for relief of constipation.

Manufacturing Process

Preparation of (4,4'-Dihydroxy-Diphenyl)-(Pyridyl-2)-Methane 70.0 grams of α-pyridine aldehyde are fed portionwise with stirring and cooling to a mixture of 200 grams of phenol and 100 cc of concentrated sulfuric acid. The reaction mixture is allowed to stand for a while with repeated stirring, whereby it becomes syrupy, neutralized with sodium carbonate, dissolved in methanol and filtered. The filtrate is introduced into a large quantity of water and the resulting precipitate is recrystallized from a methanol/water mixture. Colorless crystals are obtained of MP 254°C. When using zinc chloride or tin tetrachloride and warming to a temperature of about 50°C, a corresponding result is obtained.
Preparation of Bisacodyl: 5 grams of (4,4'-dihydroxy-diphenyl)-(pyridyl-2)- methane are heated with 5 grams of anhydrous sodium acetate and 20 cc of acetic anhydride for three hours over a boiling water bath. The cooled reaction mixture is poured into water, whereby after a while a colorless substance precipitates, which is filtered off with suction, washed with water and recrystallized from aqueous ethanol. Colorless bright crystals, MP 138°C are obtained.

brand name

Correctol Tablets, Caplets (Schering-Plough HealthCare); Dulcolax (Boehringer Ingelheim); Evac-Q-Tabs (Savage); Feen-a- Mint Tablets (Schering-Plough HealthCare); Modane (Savage); SK-Bisacodyl (SmithKline Beecham); Theralax (SmithKline Beecham).

Therapeutic Function

Laxative

Veterinary Drugs and Treatments

Bisacodyl oral and rectal products are used as stimulant cathartics in dogs and cats.

Bisacodyl Preparation Products And Raw materials

Raw materials

Preparation Products


Bisacodyl Suppliers

Global( 313)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3283 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 ericqiao@jnchsd.com CHINA 158 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
0531-88113608 info@pharmachemm.com CHINA 200 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 494 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58

View Lastest Price from Bisacodyl manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-22 Bisacodyl
603-50-9
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-28 Bisacodyl
603-50-9
US $1.00 / KG 1KG 98%~101%,BP2018 1000kg/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-10-29 Bisacodyl
603-50-9
US $200.00-50.00 / KG 1KG 99.9% 10000 Shijiazhuang Erche Biotechnology Co., Ltd

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