S3I-201
- CAS No.
- 501919-59-1
- Chemical Name:
- S3I-201
- Synonyms
- CS-450;106202;S2I-201;S31-201;S3I-201;NSC 74859;S3I-201, >98%;NSC 74859, >=98%;S3I-201 USP/EP/BP;NSC 74859(S31-201)
- CBNumber:
- CB22452397
- Molecular Formula:
- C16H15NO7S
- Molecular Weight:
- 365.36
- MDL Number:
- MFCD09907564
- MOL File:
- 501919-59-1.mol
- MSDS File:
- SDS
Melting point | >185oC (dec.) |
---|---|
Boiling point | 654.7±55.0 °C(Predicted) |
Density | 1.507 |
storage temp. | -20°C |
solubility | DMSO: >10mg/mL |
pka | 2.98±0.10(Predicted) |
form | powder |
color | white to beige |
FDA UNII | JG1E8503OI |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319 |
Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
WGK Germany | 3 |
S3I-201 price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 573102 | STAT3 Inhibitor VI, S3I-201 | 501919-59-1 | 10mg | $245 | 2024-03-01 | Buy |
Sigma-Aldrich | 573102 | STAT3 Inhibitor VI, S3I-201 | 501919-59-1 | 25mg | $390 | 2024-03-01 | Buy |
Cayman Chemical | 14336 | S3I-201 ≥95% | 501919-59-1 | 5mg | $63 | 2024-03-01 | Buy |
Cayman Chemical | 14336 | S3I-201 ≥95% | 501919-59-1 | 10mg | $117 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0330 | S3I-201 ≥97% (HPLC) | 501919-59-1 | 5mg | $110 | 2024-03-01 | Buy |
S3I-201 Chemical Properties,Uses,Production
Uses
A chemical probe inhibitor of STAT3 with an IC50 of 86 μM.
Uses
S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
- to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
- to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
- to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells
Uses
S2I-201 is a small molecule inhibitor that provides a pathway to rational combination therapies for Melanoma.
Definition
ChEBI: An amidobenzoic acid obtained by formal condensation of the carboxy group of [(4-methylbenzene-1-sulfonyl)oxy]acetic acid with the amino group of 4-amino-2-hydroxybenzoic acid.
Biological Activity
s3i-201 is a selective inhibitor of stat3 with ic50 value of 86 μm [1].in the in vitro stat3 dna-binding assay, s3i-201 showed potent inhibition of the stat3 dna-binding activity with an average ic50 of 86 μm. in the emsa assay, s3i-201 selectively inhibited stat3 dna-binding activity over that of stat1 and stat5. it suppressed the complex formation of stat1-stat3 and stat1-stat1 with ic50 values of 160 and > 300 μm, respectively. besides that, the unphosphorylated, inactive stat3 monomer was found to restore the stat3 dna-binding activity inhibited by s3i-201, suggesting that the inhibition was independent on the activation status. in nih 3t3/v-src fibroblasts, s3i-201 inhibited the constitutive activation of stat3 and reduced the ptyr-705 stat3 levels. moreover, s3i-201 was found to significantly induce apoptosis in cells with constitutively active stat3 at concentration of 30–100 μm. s3i-201 also reduced the expression of cyclin d1, bcl-xl and surviving in these cells [1].
Biochem/physiol Actions
S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
storage
-20°C
References
[1] siddiquee k, zhang s, guida w c, et al. selective chemical probe inhibitor of stat3, identified through structure-based virtual screening, induces antitumor activity. proceedings of the national academy of sciences, 2007, 104(18): 7391-7396.
S3I-201 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
View Lastest Price from S3I-201 manufacturers
501919-59-1(S3I-201)Related Search:
1of4