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TYRPHOSTIN A9

TYRPHOSTIN A9 structure

CAS No.: 10537-47-0

Chemical Name:: TYRPHOSTIN A9

Synonyms: AG 17;CS-743;SF 6847;gcp5126;s-15126;RG 50872;ent27910;MALONABEN;MALONOBEN;Malonobene

CBNumber:: CB2245711

Molecular Formula:: C18H22N2O

Molecular Weight:: 282.38

MDL Number:: MFCD00209853

MOL File:: 10537-47-0.mol

Last updated:2025-08-06 15:14:14

Product description	Number	Pack Size	Price
Tyrphostin A9 solid	T182	5mg	$114
2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE Aldrich^CPR	S481777	1 unit	$185
2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE AldrichCPR	S481777	25MG	$179
AG 17	658425	5mg	$85.2
Tyrphostin A9 >98.0%(GC)	T3667	25mg	$69
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TYRPHOSTIN A9 Properties

Melting point	141-143℃ (ethanol )
Boiling point	424.99°C (rough estimate)
Density	1.0741 (rough estimate)
refractive index	1.5700 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	ethanol: 20 mg/mL
form	solid
pka	7.55±0.40(Predicted)
color	yellow
biological source	synthetic (organic)
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference	10537-47-0(CAS DataBase Reference)
FDA UNII	87TE8MRS65
EPA Substance Registry System	Malonoben (10537-47-0)
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301+H311

Precautionary statements

P264-P270-P280-P301+P310-P302+P352+P312-P361+P364

Hazard Codes

Risk Statements

23/24/25

Safety Statements

36/37/39-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

OO3737000

HS Code

2926.90.5050

HazardClass

6.1

NFPA 704

	0
4		0

TYRPHOSTIN A9 price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T182	Tyrphostin A9 solid	10537-47-0	5mg	$114	2025-07-31	Buy
Sigma-Aldrich	S481777	2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE Aldrich^CPR	10537-47-0	1 unit	$185	2025-07-31	Buy
Sigma-Aldrich	S481777	2-(3,5-DI-TERT-BUTYL-4-HYDROXY-BENZYLIDENE)-MALONONITRILE AldrichCPR	10537-47-0	25MG	$179	2024-03-01	Buy
Sigma-Aldrich	658425	AG 17	10537-47-0	5mg	$85.2	2024-03-01	Buy
TCI Chemical	T3667	Tyrphostin A9 >98.0%(GC)	10537-47-0	25mg	$69	2025-07-31	Buy

Product number	Packaging	Price	Buy
T182	5mg	$114	Buy
S481777	1 unit	$185	Buy
S481777	25MG	$179	Buy
658425	5mg	$85.2	Buy
T3667	25mg	$69	Buy

TYRPHOSTIN A9 Chemical Properties,Uses,Production

Description

Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50?= 1.2 μM)1and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria.3 Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells.4

Uses

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Uses

Selective inhibitor of PDGF receptor tyrosine kinase

Uses

SF 6847 is an inhibitor of EGFR with IC50 of 460 μM.

Definition

ChEBI: Malonoben is an alkylbenzene. It has a role as a geroprotector.

General Description

A selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.

Biological Activity

Potent uncoupler of oxidative phosphorylation.

Biochem/physiol Actions

Cell permeable: yes

References

[1] G E BILDER. Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells.[J]. American Journal of Physiology, 1991, 260 4 Pt 1: C721-30. DOI:10.1152/ajpcell.1991.260.4.c721
[2] TERADA H. The interaction of highly active uncouplers with mitochondria[J]. Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1981, 639 3: Pages 225-242. DOI:10.1016/0304-4173(81)90011-2
[3] A M BURGER. Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria.[J]. Cancer research, 1995, 55 13: 2794-2799.
[4] THYBERG J. Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells[J]. European journal of cell biology, 1998, 76 1: Pages 33-42. DOI:10.1016/s0171-9335(98)80015-0

TYRPHOSTIN A9 synthesis

Synthesis of TYRPHOSTIN A9 from Malononitrile and 3,5-Di-tert-butyl-4-hydroxybenzaldehyde

TYRPHOSTIN A9 Preparation Products And Raw materials

Raw materials

3,5-Di-tert-butyl-4-hydroxybenzaldehyde Malononitrile

Preparation Products

TYRPHOSTIN A9 Suppliers

Global( 164)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29846	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20284	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from TYRPHOSTIN A9 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-06	TYRPHOSTIN A9OLECARBOXYLATE 10537-47-0	US $1.00 / KG	1KG	95%~99%	per week 100kg	Career Henan Chemical Co

TYRPHOSTIN A9OLECARBOXYLATE
10537-47-0
US $1.00 / KG
95%~99%
Career Henan Chemical Co

TYRPHOSTIN A9 Spectrum

TYRPHOSTIN A9(10537-47-0)¹HNMR

10537-47-0(TYRPHOSTIN A9)Related Search:

TYRPHOSTIN 25,TYRPHOSTIN A25 TYRPHOSTIN A23,TYRPHOSTIN 23,AG 18 (Tyrphostin A23) TYRPHOSTIN 63,TYRPHOSTIN A63 TYRPHOSTIN A1,TYRPHOSTIN 1 TYRPHOSTIN A51,TYRPHOSTIN 51

AG 213 (Tyrphostin AG 213),TYRPHOSTIN 47,TYRPHOSTIN A47 TYRPHOSTIN AG 1288 TYRPHOSTIN AG 835 TYRPHOSTIN AG 528 TYRPHOSTIN A10

AG 494 (Tyrphostin AG 494) AG 490 (Tyrphostin AG 490) TYRPHOSTIN A9 AG 490 AG 1478

TYRPHOSTIN 957 AG 1295 2-Propenoic acid, 2-cyano-3-(3,4-dihydroxyphenyl)-, (2E)- (9CI)

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ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)CINNAMONITRILE TYRPHOSTIN A9 \ SELECTIVE PDGF TYROSINE TYRPHOSTIN A9 99+% Malonobene 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)Malononitrile Tyrphostin 9 (SF 6847) Propanedinitrile, 2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]- [[3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXYPHENYL]METHYLENE]-PROPANEDINITRILE 3,5-DI-T-BUTYL-4-HYDROXY-BENZYLIDENEMALONONITRILE 3,5-DI-TERT-BUTYL-4-HYDROXYBENZYLIDENEMALONONITRILE AG 17 2-[(3,5-DITERT-BUTYL-4-HYDROXYPHENYL)METHYLIDENE]PROPANEDINITRILE 2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol 3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile Tyrphostin 9/AG9 TYRPHOSTIN 9;NSC 242557; RG-50872;AG 17; GCP 5126 Tyrphostin 9 (RG-50872, Malonaben, SF 6847) NSC 242557 SF 6847 RARECHEM AL BX 0198 RG 50872 ((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-propanedinitril 2-((3,5-bis(1,1-dimethyl)-4-hydroxyphenyl)methylene)propanedinitrile 3,5-di-tert-butyl-4-hydroxybenzylidene-malononitril ent27910 gcp5126 gulfs-15126 s-15126 TYRPHOSTIN 9 TYRPHOSTIN A9 TYRPHOSTIN AG 17 TYRPHOSTIN RG 50872 CHEMBRDG-BB 5272363 MALONABEN MALONOBEN Tyrphostin A9 (AG 17) AG 17 - CAS 10537-47-0 - Calbiochem Tyrphostin 9(AG-17) TYRPHOSTIN 9;MALONOBEN;TYRPHOSTIN AG-17;SF 6847;GCP 5126;RG-50872;NSC 242557 CS-743 Tyrphostin9, >98% TYRPHOSTIN A9OLECARBOXYLATE Tyrphostin 9 (SF 6847, RG-50872) [4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile TYRPHOSTIN A9 USP/EP/BP Malonoben Tyrphostin 9 C17896100 Tyrphostin A9 Tyrphostin 9, PDGFR tyrosine kinase inhibitor Tyrphostin A9, 10 mM in DMSO Tyrphostin 9 ，S2895 10537-47-0 Inhibitor of calcium release-activated calcium (CRAC) channels (see Dennis et al) Cell Signaling and Neuroscience BioChemical Cell Biology Kinase/Phosphatase Biology Receptor Tyrosine Kinase Inhibitors Platelet Derived Growth Factor Receptor (PDGFR)