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LY411575

LY411575 structure

CAS No.: 209984-57-6

Chemical Name:: LY411575

Synonyms: CS-509;LY411575;LY4114575;LSN-411575;LY411575, >=98%;LY411575;LY 411575;LY-411575 >=97% (HPLC);LY-411575;LY411575; LY 411575;LY411575, 98%, a γ-secretase inhibitor;(S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib

CBNumber:: CB22464309

Molecular Formula:: C26H23F2N3O4

Molecular Weight:: 479.48

MDL Number:: MFCD09832551

MOL File:: 209984-57-6.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:16

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LY411575 Properties

Boiling point	836.0±65.0 °C(Predicted)
Density	1.40
storage temp.	-20°C
solubility	DMSO: soluble5mg/mL, clear
form	powder
pka	11.79±0.20(Predicted)
color	white to beige
InChIKey	ULSSJYNJIZWPSB-CVRXJBIPSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements	24/25
WGK Germany	3
HS Code	29337900

LY411575 price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0506	LY-411575 ≥97% (HPLC)	209984-57-6	5mg	$128	2024-03-01	Buy
Sigma-Aldrich	SML0506	LY-411575 ≥97% (HPLC)	209984-57-6	25mg	$514	2024-03-01	Buy
Cayman Chemical	16162	LY411575 ≥98%	209984-57-6	1mg	$37	2024-03-01	Buy
Cayman Chemical	16162	LY411575 ≥98%	209984-57-6	5mg	$116	2024-03-01	Buy
Cayman Chemical	16162	LY411575 ≥98%	209984-57-6	10mg	$213	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0506	5mg	$128	Buy
SML0506	25mg	$514	Buy
16162	1mg	$37	Buy
16162	5mg	$116	Buy
16162	10mg	$213	Buy

LY411575 Chemical Properties,Uses,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC₅₀ = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

Uses

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Definition

ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

target

γ-secretase

LY411575 Preparation Products And Raw materials

Raw materials

Preparation Products

LY411575 Suppliers

Global( 126)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
ANHUI WITOP BIOTECH CO., LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

View Lastest Price from LY411575 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-08	LY411575 209984-57-6	US $0.01 / KG	1KG	98%; 99%	1kg; 10kg; 25kg	Career Henan Chemical Co

LY411575
209984-57-6
US $0.01 / KG
98%; 99%
Career Henan Chemical Co

LY411575 Spectrum

LY411575(209984-57-6)¹HNMR

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1of4

LY411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide (S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)- (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575 LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LSN-411575 N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide LY411575, >=98% LY-411575;LY411575; LY 411575 (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib LY411575, 98%, a γ-secretase inhibitor CS-509 LY411575;LY 411575 LY-411575 >=97% (HPLC) LY4114575 (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide 209984-57-6 C26H23F2N3O4 Inhibitor Inhibitors