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ChemicalBook >> CAS DataBase List >>[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Structure
[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID structure
CAS No.
475085-57-5
Chemical Name:
[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
Synonyms
MRE-269;MRE-269 S;ACT 333679;MRE-269 (ACT-333679);Selexipag internate 2;MRE-269-d7 Sodium Salt;Slapag metabolite ACT-333679;Selexipag metabolite ACT-333679;MRE-269 Selexipag Active Metabolite;Selexipag metabolite (ACT 333679) D8
CBNumber:
CB22467360
Molecular Formula:
C25H29N3O3
Molecular Weight:
419.52
MDL Number:
MFCD11976884
MOL File:
475085-57-5.mol
Last updated:2024-03-22 21:24:34
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[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Properties

Melting point 116 - 118°C
Boiling point 602.1±55.0 °C(Predicted)
Density 1.160
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 3.51±0.10(Predicted)
form Solid
color Off-White to Light Yellow
FDA UNII E9PC7N0DID

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
NFPA 704
0
2 0

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10010412 MRE-269 ≥98% 475085-57-5 1mg $36 2024-03-01 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 475085-57-5 5mg $87 2024-03-01 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 475085-57-5 10mg $155 2024-03-01 Buy
Cayman Chemical 10010412 MRE-269 ≥98% 475085-57-5 50mg $510 2024-03-01 Buy
TRC M750110 MRE-269 475085-57-5 10mg $120 2021-12-16 Buy
Product number Packaging Price Buy
10010412 1mg $36 Buy
10010412 5mg $87 Buy
10010412 10mg $155 Buy
10010412 50mg $510 Buy
M750110 10mg $120 Buy

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Chemical Properties,Uses,Production

Description

Prostacyclin (PGI2) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. MRE-269 is the active form of the prodrug NS-304. It is a potent and selective agonist for the human IP receptor with a Ki value of 20 nM. In contrast to PGI2, which has a half-life of 30 seconds to a few minutes in vivo, plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs. Unlike the PGI2 analogues, beraprost and iloprost, MRE-269 lacks high affinity for the EP3 receptor. As a result, MRE-269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reduced via EP3-mediated vasoconstriction.

Uses

MRE-269 an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-269 is an active metabolite of Selexipag (S253150).

Definition

ChEBI: A member of the class of pyrazines that is {4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetic acid carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. The active metabolite of selexipag, an orphan drug used for the treatm nt of pulmonary arterial hypertension.

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID Suppliers

Global( 139)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Shenzhen Excellent Biotech Co., Ltd. 		13480692018 ramyan@ex-biotech.com CHINA 954 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9571 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Shenzhen Excellent Biotech Co., Ltd. 		58
AFINE CHEMICALS LIMITED 		58
Finetech Industry Limited 		58

View Lastest Price from [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID pictures 2024-03-23 [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
475085-57-5
 US $35.00-0.90 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID pictures 2019-07-06 [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
475085-57-5
 US $2.00 / KG 1KG 98% 200KG Career Henan Chemical Co

475085-57-5([4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID)Related Search:

5-chloro-2,3-diphenylpyrazine ( 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid tert-butylester ) SELEXIPAG interMediate 2,3-DIPHENYLPYRAZINE Bromoacetic acid
2-T-BUTYL GLYCOLATE 4-(Isopropylamino)butanol 5,6-DIPHENYLPYRAZIN-2-OL N-(methylsulfonyl)glycine 2,3-Dichloro-5,6-diphenylpyrazine
Pyrazinamide Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]- 2-Pyrazinamine, N-(1-methylethyl)-5,6-diphenyl- 1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)oxy]-
Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)oxy]butoxy]-, 1,1-dimethylethyl ester Acetamide, 2-[4-[(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)- Acetamide, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-

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[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID ACT 333679 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid Selexipag Active Metabolite (ACT-333679) {4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid MRE-269 (ACT-333679) MRE-269 Selexipag Active Metabolite MRE-269 S ACT-333679; MRE269; MRE 269; ACT333679; ACT 333679 Selexipag impurity 6/Selexipag Acid/2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid Slapag metabolite ACT-333679 Selexipag metabolite ACT-333679 Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]- 2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid Selexipag internate 2 MRE-269-d7 Sodium Salt Selexipag metabolite (ACT 333679) D8 MRE-269 2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid N-(3-chloro-4-methylphenyl)-2-[2-(3,4-dimethylphenyl)-3-oxo-1H,2H,3H-pyrazolo[3,4-b]pyridin-1-yl]acetamide 2-{4-[(5,6-Diphenylpyrazin-2-y2-{4-[(5,6-Diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid 475085-57-5