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Veliparib

Abstract Biological activity In vitro In vivo Features References
Veliparib
Veliparib structure
CAS No.
912444-00-9
Chemical Name:
Veliparib
Synonyms
100936;CS-301;A861695;Veliparib;NSC 737664;ABT-888 2HCl;API VELIPARIB;Veliparib Base;VELIPARIBABT-888;Veliparib, >=98%
CBNumber:
CB22489643
Molecular Formula:
C13H16N4O.2ClH
Formula Weight:
317.218
MOL File:
912444-00-9.mol

Veliparib Properties

Boiling point:
579.0±40.0 °C(Predicted)
Density 
1.274
pka
9.22±0.30(Predicted)
CAS DataBase Reference
912444-00-9
FDA UNII
01O4K0631N
NCI Dictionary of Cancer Terms
veliparib

Veliparib Chemical Properties,Uses,Production

Abstract

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor. It kills cancer cells by blocking a protein called PARP, thereby preventing the repair of DNA or genetic damage in cancer cells and possibly making them more susceptible to anticancer treatments.
Veliparib (ABT-888) is being investigated to treat squamous and non-squamous non-small cell lung cancer, BRCA breast cancer, triple negative breast cancer and ovarian cancer.

Biological activity

Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. Phase 3.

In vitro

Veliparib (ABT-888) is a potential anti-cancer drug acting as a PARP inhibitor,which inhibits PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays,respectively.ABT-888 reduces clonogenic survival and inhibits DNA repair in H460 cells. ABT-888 inhibits the PARP activity with EC50 of 2 nM in C41 cells.

In vivo

ABT-888 inhibits PARP in B16F10 and 9L xenograft models, thus enhancing the anticancer activity of temozolomide. The Combined with other cytotoxic agents, ABT-888 shows strong antitumor effect in MX-1 xenograft model. ABT-888 reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg according to the the size of tumors in A375 and Colo829 xenograft models.

Features

ABT-888 enhances the effectiveness of common cancer treatments, such as radiation therapy and alkylating agents.

References

https://www.abbvie.com/our-science/pipeline/veliparib.html
https://en.wikipedia.org/wiki/Veliparib

Chemical Properties

Off-White Solid

Uses

ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.

Definition

ChEBI: A benzimidazole substituted with a carbamoyl group at C-4 and a (2R)-2-methylpyrrolidin-2-yl moiety at C-2. It is a potent, orally bioavailable PARP inhibitor.

Veliparib Preparation Products And Raw materials

Raw materials

Preparation Products


Veliparib Suppliers

Global( 153)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 2886 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 309 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10173 58

View Lastest Price from Veliparib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide
912444-00-9
US $1.00 / KG 1KG 98% 100KG career henan chemical co

912444-00-9(Veliparib)Related Search:


  • 100936
  • ABT888 (free base)
  • 2-[(2r)-2-methylpyrrolidin-2-yl]-1h-benzimidazole-4-carboxamide
  • Veliparib or (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide
  • 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4- carboxamide
  • 1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-
  • 2-((R)-2-Methylpyrrolidin-2-yl)-1H-benzimidazole-4-carboxamide
  • A861695
  • 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
  • Veliparib
  • ABT-888,Veliparib
  • Veliparib(chiral)
  • 2-[(R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benziMidazole-4-carboxaMide
  • VELIPARIBABT-888
  • API VELIPARIB
  • ABT-888 (Veliparib, NSC 737664)
  • ABT 888 - Veliparib | A 861695
  • CS-301
  • ABT-888 2HCl
  • (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]iMidazole-4-carboxaMide
  • NSC 737664
  • 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide Veliparib (ABT-888)
  • Veliparib 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide
  • (R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide (VELIPARIB)
  • (S)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide
  • Veliparib, >=98%
  • ABT888 hydrochloride
  • Veliparib Base
  • Veliparib free base
  • Veliparib 2-[(2R)-2
  • (R)-2-(2-methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide, Veliparib
  • ABT-888;ABT 888;ABT888;NSC 737664
  • 912444-00-9
  • Amines
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitor
  • PARP
  • API
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