3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
- CAS No.
- 26680-10-4
- Chemical Name:
- 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
- Synonyms
- Lactide polymer;RESOMER? R 202 H;RESOMER? R 203 S;RESOMER? R 202 S;RESOMER? R 203 H;RESOMER(R) R 203 S;RESOMER(R) R 202 S;RESOMER(R) R 202 H;RESOMER(R) R 203 H;Resomer R 202 H, Poly(D,L-lactide)
- CBNumber:
- CB22490072
- Molecular Formula:
- C6H8O4
- Molecular Weight:
- 144.12532
- MDL Number:
- MFCD00217751
- MOL File:
- 26680-10-4.mol
| Melting point | 215 °C |
|---|---|
| Density | 1.23 g/cm3 |
| Flash point | 113°C |
| storage temp. | 2-8°C |
| solubility | Soluble in dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, and acetone. Insoluble in water. |
| form | solid |
| FDA UNII |
POLYLACTIDE (459TN2L5F5) POLYLACTIDE (0.4 DL/G) (7B01B0FN51) POLYLACTIDE (14000 MW) (9J7G894K2M) POLYLACTIDE (23000 MW) (E14P5SD3J4) |
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 719943 | Poly(D,L-lactide) acid terminated, Mw 18,000-24,000 | 26680-10-4 | 5g | $323 | 2024-03-01 | Buy |
| Sigma-Aldrich | 769835 | Resomer® R 205 S, Poly(D,L-lactide) ester terminated | 26680-10-4 | 1G | $89.9 | 2023-06-20 | Buy |
| Sigma-Aldrich | 769835 | Resomer® R 205 S, Poly(D,L-lactide) ester terminated | 26680-10-4 | 5G | $284 | 2023-06-20 | Buy |
| Sigma-Aldrich | 719943 | Poly(D,L-lactide) acid terminated, Mw 18,000-24,000 | 26680-10-4 | 1g | $96.1 | 2023-06-20 | Buy |
| Sigma-Aldrich | 805734 | Poly(D,L-lactide) acid terminated, average Mw 15000 | 26680-10-4 | 5g | $329 | 2024-03-01 | Buy |
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Chemical Properties,Uses,Production
Chemical Properties
Poly(DL-lactic acid) is a glassy material, occurring as white to golden-yellow pellets or granules.
Uses
May be used to make drug delivery materials for controlled release.
Definition
ChEBI: Lactide is a member of dioxanes.
Production Methods
Lactic acid is a chiral molecule and has two optically active forms: Llactic acid and D-lactic acid. Poly(DL-lactic acid) is produced from the racemic mixture of lactic acid. Lactic acid is produced either from ethylene (petrochemical pathway) or by bacterial fermentation of D-glucose derived from food stocks. The former pathway involves an oxidation step followed by treatment with hydrogen cyanide and produces only racemic DL-lactic acid. In contrast, lactic acid produced by fermentation occurs mainly as L-lactic acid. Lowmolecular- weight poly-DL-(lactic acid) (500–10 000 Da) is produced directly from lactic acid by condensation. Higher-molecular-weight product is produced by one of two major pathways. The first involves a depolymerization of low-molecular-weight polymer into the cyclic dimer form (lactide) followed by ring-opening polymerization. Alternatively, it can be produced by a direct condensation using azeotropic distillation.
General Description
Resomer? R 207 S, Poly(D,L-lactide) (PDLLA), a biodegradable and biocompatible polymer, can be used for a variety of biological applications. It shows properties like long degradation time, mechanical stiffness and hydrophobicity.
Pharmaceutical Applications
Poly(DL-lactic acid) is used in drug delivery systems in implants, injections, and oral solid dispersions. It is also used as a coating agent.
Safety
Poly(DL-lactic acid) degrades to produce lactic acid, which is considered a well-tolerated nontoxic material. Several in vitro and in vivo studies demonstrated that poly(lactic acid) in general (including poly(DL-lactic acid)) is well tolerated and does not induce a significant immune response.However, some studies have illustrated signs of a mild immune response.The FDA has also reported some rare cases of inflammatory responses in patients treated with cosmetic poly(DL-lactic acid) injections.
storage
Poly(DL-lactic acid) is stable under dry conditions. However, it typically biodegrades over a period of 10–15 months according to the molecular weight. Increasing moisture and temperature enhances biodegradation; the onset of degradation in water at 25°C is 6 months.In contrast to many other biodegradable polymers, poly(DL-lactic acid) degrades through a two-step mechanism. The primary degradation step involves the hydrolysis of the ester bonds independently of microbial activity to produce a low-molecular-weight polymer. When the molecular weight drops below 10 000, microorganisms digest the polymer into carbon dioxide and water. Poly(DL-lactic acid) is more stable than poly(L-lactic acid) or poly(D-lactic acid) alone.Poly(DL-lactic acid) should be stored in a dry inert environment at a temperature of －15°C to －20°C.
Incompatibilities
Incompatible with strong acids or alkaline materials.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM, powder, for injection, suspension, and lyophilization). Poly(DL-lactic acid) is considered as ‘not hazardous’ according to the European Directive 67/548/EEC. Included in parenteral preparations (prolongedrelease powder for suspension for subcutaneous or intramuscular injection) licensed in the UK.
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3586 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Zhuoer Chemical Co., Ltd | 02120970332; +8613524231522 | sales@zhuoerchem.com | China | 3015 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
View Lastest Price from 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-07-22 | 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
26680-10-4
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-04-25 | 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
26680-10-4
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
26680-10-4
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
26680-10-4
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd