(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
- CAS No.
- 1156491-10-9
- Chemical Name:
- (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
- Synonyms
- (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
- CBNumber:
- CB22498775
- Molecular Formula:
- C9H10ClF2N
- Molecular Weight:
- 205.63
- MDL Number:
- MFCD16875501
- MOL File:
- 1156491-10-9.mol
Melting point | >172°C (dec.) |
---|---|
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | White |
InChI | InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3 |
InChIKey | IMYLOCHFFLYHPS-RHUSADAZNA-N |
SMILES | N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl |&1:1,3,r| |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-M1888 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride ≥99.0% | 1156491-10-9 | 25g | $188 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 93228 | (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride | 1156491-10-9 | 250mg | $370 | 2021-12-16 | Buy |
AK Scientific | J96448 | (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride | 1156491-10-9 | 25g | $500 | 2021-12-16 | Buy |
Alichem | 1156491109 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride | 1156491-10-9 | 25g | $505 | 2021-12-16 | Buy |
Chemenu | CM117627 | trans-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride 95+% | 1156491-10-9 | 1000g | $960 | 2021-12-16 | Buy |
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Chemical Properties,Uses,Production
Physical Form
Solid
Uses
(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700).
Synthesis Reference(s)
Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1
Synthesis
1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to
produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by
addition of N,N-dimethylformamide,
phloroglucinol and sodium iodide in the next step converted to
1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the
latter intermediate is in the subsequent step stereochemically reduced
to hydroxyl group by the use of chiral oxazaborolidine together with
borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol
is then added to a mixture of triphenylphosphine and
diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust.
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Safer Pharmaceutical Technology Co., Ltd. | 021-31761238 | sales@saferph.com | CHINA | 897 | 58 |
Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | chang@shjlchem.com | China | 20 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531153977 | allison@yan-xi.com | China | 5855 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20260 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 970 | 58 |
HEBEI BRANT PHARMACEUTICAL CO.,LTD | +86-311-84455288 +86-18832137600 | rice@brantpharm.com | China | 17 | 58 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21632 | 55 |
View Lastest Price from (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2025-02-18 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
|
US $5.00 / kg | 1kg | ≥99% | 20mt/year | Jinan Finer Chemical Co., Ltd | |
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2025-02-18 | (1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine
1156491-10-9
|
US $0.00-0.00 / kg | 1kg | 98 | 1000 | Wuhan Circle Star Chem-medical Technology Co.,Ltd | |
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2025-02-17 | (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd |
-
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
- US $5.00 / kg
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- (1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine
1156491-10-9
- US $0.00-0.00 / kg
- 98
- Wuhan Circle Star Chem-medical Technology Co.,Ltd
-
- (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
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