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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride structure

CAS No.: 1156491-10-9

Chemical Name:: (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride

Synonyms: (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;(1R,2S)-rel-2-(3,4;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;Ticagrelor Impurity 305 Hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo

CBNumber:: CB22498775

Molecular Formula:: C9H10ClF2N

Molecular Weight:: 205.63

MDL Number:: MFCD16875501

MOL File:: 1156491-10-9.mol

MSDS File:: SDS

Last updated:2025-07-14 15:27:00

Product description	Number	Pack Size	Price
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride ≥99.0%	CS-M1888	25g	$188
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride	93228	250mg	$370
(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride	J96448	25g	$500
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride	1156491109	25g	$505
trans-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride 95+%	CM117627	1000g	$960
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(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Properties

Melting point	>172°C (dec.)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White
InChI	InChI=1/C9H9F2N.ClH/c10-7-2-1-5(3-8(7)11)6-4-9(6)12;/h1-3,6,9H,4,12H2;1H/t6-,9+;/s3
InChIKey	IMYLOCHFFLYHPS-RHUSADAZNA-N
SMILES	N[C@@H]1C[C@H]1C1C=CC(F)=C(F)C=1.Cl \|&1:1,3,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-M1888	(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride ≥99.0%	1156491-10-9	25g	$188	2021-12-16	Buy
Medical Isotopes, Inc.	93228	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride	1156491-10-9	250mg	$370	2021-12-16	Buy
AK Scientific	J96448	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride	1156491-10-9	25g	$500	2021-12-16	Buy
Alichem	1156491109	(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride	1156491-10-9	25g	$505	2021-12-16	Buy
Chemenu	CM117627	trans-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride 95+%	1156491-10-9	1000g	$960	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-M1888	25g	$188	Buy
93228	250mg	$370	Buy
J96448	25g	$500	Buy
1156491109	25g	$505	Buy
CM117627	1000g	$960	Buy

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Chemical Properties,Uses,Production

Physical Form

Solid

Uses

(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700).

Synthesis Reference(s)

Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1

Synthesis

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine 1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by addition of N,N-dimethylformamide, phloroglucinol and sodium iodide in the next step converted to 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the latter intermediate is in the subsequent step stereochemically reduced to hydroxyl group by the use of chiral oxazaborolidine together with borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol is then added to a mixture of triphenylphosphine and diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust.

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Suppliers

Global( 257)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Safer Pharmaceutical Technology Co., Ltd.	021-31761238	sales@saferph.com	CHINA	897	58
Shanghai Jinli Pharmaceutical Co.,Ltd	+86-21-57256005 +86-15921811235	chang@shjlchem.com	China	20	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
HEBEI BRANT PHARMACEUTICAL CO.,LTD	+86-18713118368 +86-18713118368	lisa@brantpharm.com	China	17	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	810	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

Supplier	Advantage
Shanghai Safer Pharmaceutical Technology Co., Ltd.	58
Shanghai Jinli Pharmaceutical Co.,Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
HEBEI BRANT PHARMACEUTICAL CO.,LTD	58
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-15	(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride 1156491-10-9	US $5.00 / kg	1kg	≥99%	20mt/year	Jinan Finer Chemical Co., Ltd
2026-04-12	(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine 1156491-10-9	US $1.00 / kg	1kg	98	1000	S&Y Biochem Co.,Ltd
2026-04-09	(1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine Hydrochloride 1156491-10-9	US $0.00 / KG Ton	1KG Ton	98%+	2 tons/month	ZHUHAI HRD PHARMACEUTICAL CO., LTD.

(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
1156491-10-9
US $1.00 / kg
98
S&Y Biochem Co.,Ltd

(1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine Hydrochloride
1156491-10-9
US $0.00 / KG Ton
98%+
ZHUHAI HRD PHARMACEUTICAL CO., LTD.

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Spectrum

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride(1156491-10-9)¹HNMR

1156491-10-9((1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride)Related Search:

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TICAGRELOR 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid 4,6-dichloro-2-propylthiopyrimidine-5-amine 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE (3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-ol

(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate 1-Acetyladamantane Intermediate (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine. HCl Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- ethyCyclopropanamine, 2-(3,4-difluorophenyl)-, (1R,2S)- (REACH)

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide CarbaMicacid,N-[(3aS,4R,6S,6aR)-tetrahydro-6-hydroxy-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]-,phenylMethyl ester Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1)

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(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami 2-(3,4-Difluoro-phenyl)-cyclopropylamine (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL- trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochlorideQ: What is (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the CAS Number of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the storage condition of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochl... (1R,2S)-REL-2-(3,4-difluorophenyl)cyclopropane amine chloride Ticagrelor side chain 2 hydrochloride trans-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride Ticagrelor USP RC A trans-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride (1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride trans-(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1) (1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine (1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride, (1R,2S)-rel-2-(3,4-Difluorophenyl)-cyclopropanamine hydrochloride (1:1) (1R, 2S) - REL-2- (3,4-difluorophenyl) cyclopropylamine hydrochloride 1R trans)-2-(3,4-difluorophenyl)cyclopropane amine in stock (1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochlo trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine hydrochloride (1R,2S)-Rel-2-(3,4-Difluorophenyl)-Cyclopropanamine Hydr (1R,trans)-2-(3,4-difluorophenyl) Cyclopropanamine hydrochloride (1R,2S)-rel-2-(3,4 Ticagrelor Impurity 305 Hydrochloride 1156491-10-9 C9H9F2NHCl Intermediate of Ticagrelor 1156491-10-9