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(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine

CAS No.
1156491-10-9
Chemical Name:
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
Synonyms
(1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1);(1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride;Ticagrelor USP RC A;Ticagrelor side chain 2 hydrochloride;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami;(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl
CBNumber:
CB22498775
Molecular Formula:
C9H10ClF2N
Molecular Weight:
205.63
MDL Number:
MFCD16875501
MOL File:
1156491-10-9.mol
Last updated:2023-10-26 13:06:26

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Properties

Melting point >172°C (dec.)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-M1888 (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride ≥99.0% 1156491-10-9 25g $188 2021-12-16 Buy
Medical Isotopes, Inc. 93228 (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride 1156491-10-9 250mg $370 2021-12-16 Buy
AK Scientific J96448 (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride 1156491-10-9 25g $500 2021-12-16 Buy
Alichem 1156491109 (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanaminehydrochloride 1156491-10-9 25g $505 2021-12-16 Buy
Chemenu CM117627 trans-2-(3,4-Difluorophenyl)cyclopropanamineHydrochloride 95+% 1156491-10-9 1000g $960 2021-12-16 Buy
Product number Packaging Price Buy
CS-M1888 25g $188 Buy
93228 250mg $370 Buy
J96448 25g $500 Buy
1156491109 25g $505 Buy
CM117627 1000g $960 Buy

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Chemical Properties,Uses,Production

Physical Form

Solid

Uses

(1S,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine is an intermediate used to prepare ticagrelor (T437700).

Synthesis Reference(s)

Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts. EU Patent EP2644590A1

Synthesis

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine1,2-Difluorobenzene is reacted with 3-chloropropionyl chloride to produce 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one, which is by addition of N,N-dimethylformamide, phloroglucinol and sodium iodide in the next step converted to 1-(3',4'-difluorophenyl)-3-nitro-propan-1-one. The keto group of the latter intermediate is in the subsequent step stereochemically reduced to hydroxyl group by the use of chiral oxazaborolidine together with borane dimethyl sulfide or borane-N,N-diethyl aniline complex in the presence of tetrahydrofurane. The obtained (1R)-1-(3',4'-difluorophenyl)-3-nitro-propan-1-ol is then added to a mixture of triphenylphosphine and diethylazodicarboxylate in benzene to yield (1S,2R)-2-(3',4'-difluorophenyl)-1-nitrocyclopropane, which is in the last step converted to 2-(3,4-difluorophenyl)cyclopropane amine by reduction of the nitro group by catalytic hydrogenation with palladium catalyst and zink dust. 

(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 243)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Safer Pharmaceutical Technology Co., Ltd.
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Shanghai Jinli Pharmaceutical Co.,Ltd
+86-21-57256005 +86-15921811235 chang@shjlchem.com China 20 58
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+8617531190177 peter@yan-xi.com China 5921 58
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+86-371-66670886 info@dakenam.com China 14638 58
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951 CHINA 115 55
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010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Hi-Tech Chemistry Corp
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Henan Tianfu Chemical Co.,Ltd.
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Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9360 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32294 60

View Lastest Price from (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride pictures 2024-02-23 (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride
1156491-10-9
US $5.00 / kg 1kg ≥99% 20mt/year Jinan Finer Chemical Co., Ltd
(1R trans)-2-(3,4-difluorophenyl)cyclopropane amine pictures 2023-10-24 (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine
1156491-10-9
US $0.00-0.00 / kg 1kg 99 20tons Hebei Yanxi Chemical Co., Ltd.
(1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine Hydrochloride pictures 2023-09-08 (1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine Hydrochloride
1156491-10-9
US $0.00 / KG Ton 1KG Ton 98%+ 2 tons/month Zhuhai Hairuide Bioscience and Technology Co., Ltd
(1R,2S)-2-(3,4-Difluorophenyl)-cyclopropan-1-aMine HCL (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanami 2-(3,4-Difluoro-phenyl)-cyclopropylamine (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL- trans-(1R,2S)-2-(3,4-difluorphenyl)cyclopropylaMine (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine HCl (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochlorideQ: What is (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the CAS Number of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride Q: What is the storage condition of (1R,2S)-rel-2-(3,4-Difluorophenyl) cyclopropanamine hydrochloride (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine hydrochl... (1R,2S)-REL-2-(3,4-difluorophenyl)cyclopropane amine chloride Ticagrelor side chain 2 hydrochloride trans-rel-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride Ticagrelor USP RC A trans-2-(3,4-Difluorophenyl)cyclopropanamine Hydrochloride (1R,2S)-2-(3,4-difluorophenyl)cyclopropane amine hydrochloride trans-(1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl (1R,2S)-2-(3,4-difluorophenyl)cyclopropanaMine Hydrochloride(1:1) (1R trans)-2-(3,4-difluorophenyl)cyclopropane aMine hydrochloride (1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride (1S,2R)-2-(3,4-difluorophenyl)cyclopropanaMine (1R,2S)-2-(3,4-Diflurophenyl)cyclopropylamine hydrochloride, (1R,2S)-rel-2-(3,4-Difluorophenyl)-cyclopropanamine hydrochloride (1:1) (1R, 2S) - REL-2- (3,4-difluorophenyl) cyclopropylamine hydrochloride 1R trans)-2-(3,4-difluorophenyl)cyclopropane amine in stock (1R,2S)-rel-2-(3,4- Difluorophenyl)cyclo 1156491-10-9 C9H9F2NHCl Intermediate of Ticagrelor 1156491-10-9