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JAK3 Inhibitor

JAK3 Inhibitor Structure
JAK3 Inhibitor structure
CAS No.
211555-04-3
Chemical Name:
JAK3 Inhibitor
Synonyms
CS-1516;whi-p154cas;JAK3 Inhibitor;JAK3 Inhibitor II WHI-P154;JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem;2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol;2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol;Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]-;4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154;Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR
CBNumber:
CB22502881
Molecular Formula:
C16H14BrN3O3
Molecular Weight:
376.2
MDL Number:
MFCD02179366
MOL File:
211555-04-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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JAK3 Inhibitor Properties

Melting point 230 °C
Boiling point 470.3±45.0 °C(Predicted)
Density 1.576±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble1mg/mL, clear (warmed)
pka 8.57±0.31(Predicted)
form powder
color white to brown
InChIKey CBIAKDAYHRWZCU-UHFFFAOYSA-N
CAS DataBase Reference 211555-04-3
FDA UNII PG8BT6T9MB

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P261-P301+P310-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933.59.8000
NFPA 704
0
2 0

JAK3 Inhibitor price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 420104 JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem 211555-04-3 5MG $303 2024-03-01 Buy
TCI Chemical W0013 WHI-P154 211555-04-3 10MG $139 2024-03-01 Buy
TCI Chemical W0013 WHI-P154 211555-04-3 50MG $417 2024-03-01 Buy
Cayman Chemical 16178 WHI-P154 ≥98% 211555-04-3 5mg $81 2024-03-01 Buy
Cayman Chemical 16178 WHI-P154 ≥98% 211555-04-3 10mg $129 2024-03-01 Buy
Product number Packaging Price Buy
420104 5MG $303 Buy
W0013 10MG $139 Buy
W0013 50MG $417 Buy
16178 5mg $81 Buy
16178 10mg $129 Buy

JAK3 Inhibitor Chemical Properties,Uses,Production

Description

WHI-P154 is a quinazoline derivative that exhibits immunosuppressive effects by selectively inhibiting JAK3 (IC50 = 1.8 μM versus IC50s > 10 μM for JAK1 and JAK2). It has been reported to inhibit additional kinases including EGFR (IC50 = 4 nM) and VEGFR as well as the non-receptor tyrosine kinases, Abl, Lck, and Src. WHI-P154 is cytotoxic to human glioblastoma cells (IC50 = 813 nM) and has been used to induce the differentiation of neuronal precursor cells.

Uses

WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM and also inhibits EGFR with IC50 of 4 nM.

Uses

WHI-P154 can act as antileukemic agent with apoptosis inducing activity.

Biochem/physiol Actions

WHI-P154 is a specific inhibitor of JAK3 (IC50 = 1.8 μM) with no inhibitory activity against JAK1 or JAK2. WHI-P154 enhances myogenic differentiation of C2C12 mouse myoblast cells, and induces differentiation of neural progenitor cells. The compound WHI-P154 dose dependently inhibits expression of iNOS and NO production in LPS-challenged macrophages.

in vitro

kinase assays show that whi-p154 is not a specific inhibitor. besides jak3, it also inhibits many other kinases, including egfr, abl, lck, src and vegfr. whi-p154 inhibits egfr with ic50 value of 4nm. the specificity of whi-p154 has not been shown in cell-based assays either [1].

storage

Store at RT

References

[1] changelian ps, moshinsky d, kuhn cf, flanagan me, munchhof mj, harris tm, whipple da, doty jl, sun j, kent cr, magnuson ks, perregaux dg, sawyer ps, kudlacz em. the specificity of jak3 kinase inhibitors. blood. 2008 feb 15;111(4):2155-7.
[2] narla rk, liu xp, myers de, uckun fm. 4-(3'-bromo-4'hydroxylphenyl)-amino-6,7-dimethoxyquinazoline: a novel quinazoline derivative with potent cytotoxic activity against human glioblastoma cells. clin cancer res. 1998 jun;4(6):1405-14.

JAK3 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

JAK3 Inhibitor Suppliers

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Hubei xin bonus chemical co. LTD 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
Coresyn Pharmatech Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from JAK3 Inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JAK3 Inhibitor pictures 2019-12-25 JAK3 Inhibitor
211555-04-3
 US $9.80 / KG 1g ≥99% 100kg Career Henan Chemical Co

JAK3 Inhibitor Spectrum

JAK3 Inhibitor(211555-04-3)1HNMR

211555-04-3(JAK3 Inhibitor)Related Search:

JAK3 INHIBITOR I 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL 2-Bromopropane 1-Bromo-3-methylbutane 2-Methylsulfonyl-4,6-dimethoxypyrimidine
WHI-P97 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Tofacitinib citrate Stattic
(+)-JQ1 ABT-199 ABT 737 Entinostat

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JAK3 Inhibitor 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol Phenol, 2-bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]- 4-(3'-Bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline WHI-P 154 2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem CS-1516 whi-p154cas JAK3 Inhibitor II WHI-P154 Janus kinase,ErbB-1,Apoptosis,inhibit,JAK,Epidermal growth factor receptor,WHI-P154,HER1,WHIP154,Inhibitor,WHI-P-154,WHI P154,EGFR 211555-04-3 Inhibitors Inhibitor JAK/STAT JAK STAT