ChemicalBook >> CAS DataBase List >>2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
![2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Structure](CAS2/GIF/324523-20-8.gif)
- CAS No.
- 324523-20-8
- Chemical Name:
- 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
- Synonyms
- NPS-2143 HCL;NPS-2143 (Mono HCl);NPS2143;NPS 2143 HCL;SB-262470-A hydrochloride;NPS2143 hydrochloride, >=98%;NPS-2143/SB-262470A hydrochloride);NPS-2143 hydrochloride (SB-262470A);2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride;(R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
- CBNumber:
- CB22509916
- Molecular Formula:
- C24H26Cl2N2O2
- Molecular Weight:
- 445.38
- MDL Number:
- MFCD16038896
- MOL File:
- 324523-20-8.mol
Last updated:2023-06-30 15:45:59
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: >10mg/mL |
| form | powder |
| color | white to beige |
| optical activity | [α]20/D +20 to +24°, c = 1.0 in methanol |
| FDA UNII | U48SZ6EBB3 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H410 | |||||||||
| Precautionary statements | P261-P273-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 20/21/22-50/53 | |||||||||
| Safety Statements | 36/37-60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0362 | NPS2143 hydrochloride ≥98% (HPLC) | 324523-20-8 | 5mg | $158 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0362 | NPS2143 hydrochloride ≥98% (HPLC) | 324523-20-8 | 25mg | $631 | 2024-03-01 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 324523-20-8 | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 324523-20-8 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 324523-20-8 | 10mg | $163 | 2024-03-01 | Buy |
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Chemical Properties,Uses,Production
Description
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM). It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously. Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.
Uses
NPS 2143 acts as a potent and selective antagonist for CaSR (Calcium-sensing receptor) which is involved in calcium blood concentration homeostasis.
Biochem/physiol Actions
NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
storage
Desiccate at RT
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 55)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride Spectrum
324523-20-8(2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride)Related Search:
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
NPS-2143 HCL
NPS-2143 (Mono HCl)
2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
SB-262470-A hydrochloride
NPS2143 hydrochloride, >=98%
NPS-2143 hydrochloride (SB-262470A)
NPS2143;NPS 2143 HCL
(R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride
NPS2143,NPS-2143,CaSR,NPS 2143 hydrochloride,Calcium-sensing receptor,inhibit,SB-262470A,Inhibitor,NPS 2143,NPS2143 hydrochloride
NPS-2143/SB-262470A hydrochloride)
324523-20-8
C24H25ClN2O2HCl