Acotiamide Hydrochloride
- CAS No.
- 185104-11-4
- Chemical Name:
- Acotiamide Hydrochloride
- Synonyms
- Acotiamide-d6 HCl;Acotiamide hydrochloride;Acotiamide Impurity 14 HCl;Acotiamide dihydrochloride;Acotiamide Impurity 20 HCl;Acetylformamide hydrochloride;Acotiamide (hydrochloride) (Acotiamide Impurity);N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoy;N-[2-[Bisisopropylamino]-ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide HCl;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide hydrochloride
- CBNumber:
- CB22510118
- Molecular Formula:
- C21H31ClN4O5S
- Molecular Weight:
- 487.01
- MDL Number:
- MFCD23103502
- MOL File:
- 185104-11-4.mol
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
|---|---|
| FDA UNII | 510791NN30 |
Acotiamide Hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A190260 | AcotiamideHydrochloride | 185104-11-4 | 5mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 0101AP | Acotiamidehydrochloride | 185104-11-4 | 250mg | $212 | 2021-12-16 | Buy |
| Chemenu | CM133484 | N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloride 97% | 185104-11-4 | 1g | $281 | 2021-12-16 | Buy |
| Crysdot | CD11178508 | Acotiamidehydrochloride 97% | 185104-11-4 | 1g | $297 | 2021-12-16 | Buy |
| Ambeed | A111223 | Acotiamidehydrochloride 98% | 185104-11-4 | 5g | $417 | 2021-12-16 | Buy |
Acotiamide Hydrochloride Chemical Properties,Uses,Production
Description
Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
Uses
Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.
Biological Activity
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
Acotiamide Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 | xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Lianyungang happen teng technology co., LTD | 15950718863 | wang666xt@163.com | CHINA | 295 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from Acotiamide Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-02 | Acotiamide hydrochloride
185104-11-4
|
US $10.00-100.00 / kg | 1kg | 99% | 100 tons | Wuhan Xinhao Biotechnology Co., Ltd | |
 |
2024-03-28 | Acotiamide hydrochloride
185104-11-4
|
US $0.00 / kg | 25kg | ≥99% | Inquiry | PNP Biotech Co. Ltd | |
 |
2024-01-08 | Acotiamide hydrochloride
185104-11-4
|
US $9.00 / KG | 1KG | 99% | 50000tons | Wuhan Boyuan Import & Export Co., LTD |
-
- Acotiamide hydrochloride
185104-11-4
- US $10.00-100.00 / kg
- 99%
- Wuhan Xinhao Biotechnology Co., Ltd
-
- Acotiamide hydrochloride
185104-11-4
- US $0.00 / kg
- ≥99%
- PNP Biotech Co. Ltd
-
- Acotiamide hydrochloride
185104-11-4
- US $9.00 / KG
- 99%
- Wuhan Boyuan Import & Export Co., LTD
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