Dexrazoxane | 24584-09-6

Dexrazoxane Properties

Melting point	194-196°C
alpha	D +11.35° (c = 5 in DMF)
Boiling point	531.5±50.0 °C(Predicted)
Density	1.333±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
form	powder
pka	2.1(at 25℃)
color	white to off-white
Merck	14,8123
InChIKey	BMKDZUISNHGIBY-ZETCQYMHSA-N
CAS DataBase Reference	24584-09-6(CAS DataBase Reference)
FDA UNII	048L81261F
ATC code	V03AF02

Pharmacokinetic data

Protein binding	2%
Excreted unchanged in urine	Cardioxane? : 40; Savene? : 34-60%
Volume of distribution	0.13-1.3(L/kg)
Biological half-life	Cardioxane? : 1-3.4; Savene? : 1.9-9.1 / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

3

RTECS

TL6390000

HS Code

2933.59.9500

NFPA 704

	0
2		0

Dexrazoxane price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D1446	Dexrazoxane ≥95% (HPLC)	24584-09-6	5mg	$106	2024-03-01	Buy
Sigma-Aldrich	05587	Dexrazoxane analytical standard	24584-09-6	25mg	$94.4	2024-03-01	Buy
TCI Chemical	D4227	Dexrazoxane >98.0%(T)	24584-09-6	100mg	$67	2024-03-01	Buy
Cayman Chemical	14632	Dexrazoxane ≥98%	24584-09-6	5mg	$32	2024-03-01	Buy
Cayman Chemical	14632	Dexrazoxane ≥98%	24584-09-6	10mg	$48	2024-03-01	Buy

Product number	Packaging	Price	Buy
D1446	5mg	$106	Buy
05587	25mg	$94.4	Buy
D4227	100mg	$67	Buy
14632	5mg	$32	Buy
14632	10mg	$48	Buy

Dexrazoxane Chemical Properties,Uses,Production

Description

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Originator

Imperial Cancer Research Fund (United Kingdom)

Uses

Cardioprotectant.

Uses

Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Uses

Dexrazoxane has been used in chromatin remodelling experiments.

Definition

ChEBI: (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.

brand name

Zinecard (Pharmacia & Upjohn);Cardioxane.

General Description

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Biochem/physiol Actions

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Clinical Use

Cardioxane? Prevention of cardiotoxicity in patients receiving doxorubicin or epirubicin for breast cancer Savene? : Treatment of extravasation caused by anthracyclines

Veterinary Drugs and Treatments

Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.

Drug interactions

Potentially hazardous interactions with other drugs
Antiepileptics: may reduce absorption of fosphenytoin and phenytoin.
Ciclosporin: increased risk of immunosuppression with risk of lymphoproliferative disease.
Tacrolimus: increased risk of immunosuppression with risk of lymphoproliferative disease.
Vaccines: risk of generalised infections with live vaccines - avoid.

Metabolism

Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.
It is excreted unchanged via the kidney

Dexrazoxane synthesis

Synthesis of Dexrazoxane from (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid

Dexrazoxane Preparation Products And Raw materials

Raw materials

Preparation Products

Dexrazoxane Suppliers

Global( 297)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12457	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
airuikechemical co., ltd.	58
hebei hongtan Biotechnology Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from Dexrazoxane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-22	Dexrazoxane 24584-09-6	US $60.00 / kg	1kg	99%	1000	hebei hongtan Biotechnology Co., Ltd
2024-04-03	Dexrazoxane 24584-09-6	US $0.00-0.00 / g	1g	99.9%	20tons	airuikechemical co., ltd.
2023-11-30	Dexrazoxane 24584-09-6	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd

Dexrazoxane
24584-09-6
US $60.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

Dexrazoxane
24584-09-6
US $0.00-0.00 / g
99.9%
airuikechemical co., ltd.

Dexrazoxane
24584-09-6
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Dexrazoxane Spectrum

Dexrazoxane(24584-09-6)¹HNMR

24584-09-6(Dexrazoxane)Related Search:

Methyl acrylate Methylparaben Thiophanate-methyl Methyl acetate METSULFURON METHYL

Bensulfuron methyl Kresoxim-methyl 4,4'-propylenebis(piperazine-2,6-dione) N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine ICRF 198

N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine 2,2',2'',2'''-[[(1S)-1-Methyl-1,2-ethanediyl]dinitrilo]tetrakisacetamide ICRF-186 (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid Glycine, N-(2-amino-2-oxoethyl)-N-[(2R)-2-(3,5-dioxo-1-piperazinyl)propyl]-

Glycine, N-(2-amino-2-oxoethyl)-N-[2-(3,5-dioxo-1-piperazinyl)propyl]- Dexrazoxane IMpurity D (N-oxide) Methyl

1of4

DEXRAZOXANE (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4 4’-propylenedi-6-piperazinedion(+)-4 adr529 cardioxane DEXTRAZOXANE DEXTRORAZOXANE (S)-ICRF-187 [S,(+)]-4,4'-Propylenebis(2,6-piperazinedione) 4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione) 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione) Dexrazoxane ((S)-Razoxane) 2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis- (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane Dexrazoxane (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione) Dexrazoxane, >=99% (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane Ca rdioxane、Dextrazoxane、Eucardion、Zinecard ICRF-187;NSC-169780 Dexrazoxane (ICRF-187 Dexrazoxane> (+)-dexrazoxane Dexrazoxane Impurity Dexrazoxane (NSC-169780) Right razoxane Dextrozosan. - Dextropropimide Dexrazoxane 24584-09-6 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione 24584-09-6 C11H16N4O4 API Chelating Agent 24584-09-6