N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride
![N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Structure](CAS/20180808/GIF/607378-18-7.gif)
- CAS No.
- 607378-18-7
- Chemical Name:
- N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride
- Synonyms
- AZ-10606120);AZ 10606120 (hydrochloride);AZ 10606120 dihydrochloride;AZ 10606120 Dihydrochloride (~90%);AZ10606120 dihydrochloride (AZ 10606120;2-(Adamantan-1-yl)-N-(2-((2-((2-hydroxyethyl)amino)ethyl)amino)quinolin-5-yl)acetamide dihydrochloride;N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride;P2X Receptor,AZ-10606120 dihydrochloride,Inhibitor,P2XRs,AZ10606120 dihydrochloride,inhibit,AZ10606120,AZ 10606120,AZ-10606120;N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride
- CBNumber:
- CB22518679
- Molecular Formula:
- C25H34N4O2.2HCl
- Molecular Weight:
- 459.03
- MDL Number:
- MFCD12828760
- MOL File:
- 607378-18-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3600 | AZ10606120 dihydrochloride ≥98% (HPLC) | 607378-18-7 | 10MG | $199 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3600 | AZ10606120 dihydrochloride ≥98% (HPLC) | 607378-18-7 | 50MG | $829 | 2024-03-01 | Buy |
| Tocris | 3323 | AZ10606120dihydrochloride ≥98%(HPLC) | 607378-18-7 | 50 | $839 | 2021-12-16 | Buy |
| Tocris | 3323 | AZ10606120dihydrochloride ≥98%(HPLC) | 607378-18-7 | 10 | $195 | 2021-12-16 | Buy |
| TRC | A795163 | AZ10606120Dihydrochloride(~90%) | 607378-18-7 | 1mg | $90 | 2021-12-16 | Buy |
N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Chemical Properties,Uses,Production
Uses
AZ 10606120 Dihydrochloride is a P2X7 antagonist, which is a key modulator of the PI3K/GSK3β/VEGF signaling network that is characteristic to neuroblastoma progression.
Biological Activity
kd: 1.4 nm and 1.9 nm for human and rat p2x7 receptors, respectivleythe p2x7 receptor has intriguing biophysical properties, activates a diverse range of cellular events and mediates a wide range of functional effects. the p2x7 receptor is an atp-gated ion channel known for its cytotoxic activity. however, recent evidence suggests a role for p2x7 in cell proliferation. az 10606120 is a p2x7 receptor antagonist.
in vitro
binding of [3h]-az 10606120 was higher in membranes prepared from cells expressing p2x7 receptors than from control cells and was inhibited by atp suggesting labelled sites represented human p2x7 receptors. binding was reversible, saturable and modulated by p2x7 receptor ligands. the positive cooperativity observed suggests that binding of az 10606120 to one subunit in the p2x7 receptor complex enhances subsequent binding to other p2x7 subunits in the same complex. the negative cooperative effects of atp suggest that atp and az 10606120 bind at separate, interacting, sites on the p2x7 receptor [1].
in vivo
intratumor injection of az10606120 caused a strong inhibition of tumor growth in b16-inoculated c57bl/6 mice and caused in parallel a large reduction in vegf staining and vessel formation [2].
storage
Desiccate at RT
References
[1] ad michel, lj chambers, wc clay, jp condreay, ds walter and ip chessell. direct labelling of the human p2x7 receptor and identification of positive and negative cooperativity of binding. british journal of pharmacology (2007) 151, 84–95
[2] elena adinolfi, lizzia raffaghello, anna lisa giuliani, luigi cavazzini, marina capece, paola chiozzi, giovanna bianchi, guido kroemer, vito pistoia, and francesco di virgilio. expression of p2x7 receptor increases in vivo tumor growth. cancer res; 72(12); 2957–69.
N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| ELSA BIOTECHNOLOGY CO.,LTD. | 15261860116 | sales@elsa-biotech.com | China | 99 | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4182 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8014 | 62 |