ChemicalBook >> CAS DataBase List >>N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride

CAS No.
607378-18-7
Chemical Name:
N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride
Synonyms
AZ-10606120);AZ 10606120 (hydrochloride);AZ 10606120 dihydrochloride;AZ 10606120 Dihydrochloride (~90%);AZ10606120 dihydrochloride (AZ 10606120;2-(Adamantan-1-yl)-N-(2-((2-((2-hydroxyethyl)amino)ethyl)amino)quinolin-5-yl)acetamide dihydrochloride;N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride;P2X Receptor,AZ-10606120 dihydrochloride,Inhibitor,P2XRs,AZ10606120 dihydrochloride,inhibit,AZ10606120,AZ 10606120,AZ-10606120;N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride
CBNumber:
CB22518679
Molecular Formula:
C25H34N4O2.2HCl
Molecular Weight:
459.03
MDL Number:
MFCD12828760
MOL File:
607378-18-7.mol
Last updated:2023-09-04 15:51:00

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Properties

Melting point 192-219°C
storage temp. Desiccate at RT
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
form Solid
color Pale Yellow

SAFETY

Risk and Safety Statements

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3600 AZ10606120 dihydrochloride ≥98% (HPLC) 607378-18-7 10MG $199 2024-03-01 Buy
Sigma-Aldrich SML3600 AZ10606120 dihydrochloride ≥98% (HPLC) 607378-18-7 50MG $829 2024-03-01 Buy
Tocris 3323 AZ10606120dihydrochloride ≥98%(HPLC) 607378-18-7 50 $839 2021-12-16 Buy
Tocris 3323 AZ10606120dihydrochloride ≥98%(HPLC) 607378-18-7 10 $195 2021-12-16 Buy
TRC A795163 AZ10606120Dihydrochloride(~90%) 607378-18-7 1mg $90 2021-12-16 Buy
Product number Packaging Price Buy
SML3600 10MG $199 Buy
SML3600 50MG $829 Buy
3323 50 $839 Buy
3323 10 $195 Buy
A795163 1mg $90 Buy

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Chemical Properties,Uses,Production

Uses

AZ 10606120 Dihydrochloride is a P2X7 antagonist, which is a key modulator of the PI3K/GSK3β/VEGF signaling network that is characteristic to neuroblastoma progression.

Biological Activity

kd: 1.4 nm and 1.9 nm for human and rat p2x7 receptors, respectivleythe p2x7 receptor has intriguing biophysical properties, activates a diverse range of cellular events and mediates a wide range of functional effects. the p2x7 receptor is an atp-gated ion channel known for its cytotoxic activity. however, recent evidence suggests a role for p2x7 in cell proliferation. az 10606120 is a p2x7 receptor antagonist.

in vitro

binding of [3h]-az 10606120 was higher in membranes prepared from cells expressing p2x7 receptors than from control cells and was inhibited by atp suggesting labelled sites represented human p2x7 receptors. binding was reversible, saturable and modulated by p2x7 receptor ligands. the positive cooperativity observed suggests that binding of az 10606120 to one subunit in the p2x7 receptor complex enhances subsequent binding to other p2x7 subunits in the same complex. the negative cooperative effects of atp suggest that atp and az 10606120 bind at separate, interacting, sites on the p2x7 receptor [1].

in vivo

intratumor injection of az10606120 caused a strong inhibition of tumor growth in b16-inoculated c57bl/6 mice and caused in parallel a large reduction in vegf staining and vessel formation [2].

storage

Desiccate at RT

References

[1] ad michel, lj chambers, wc clay, jp condreay, ds walter and ip chessell. direct labelling of the human p2x7 receptor and identification of positive and negative cooperativity of binding. british journal of pharmacology (2007) 151, 84–95
[2] elena adinolfi, lizzia raffaghello, anna lisa giuliani, luigi cavazzini, marina capece, paola chiozzi, giovanna bianchi, guido kroemer, vito pistoia, and francesco di virgilio. expression of p2x7 receptor increases in vivo tumor growth. cancer res; 72(12); 2957–69.

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Suppliers

Global( 36)Suppliers
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TargetMol Chemicals Inc.
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Nanjing Doge Biomedical Technology Co., Ltd
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Nantong HI-FUTURE Biology Co., Ltd.
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Wuhan Topule Biopharmaceutical Co., Ltd
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Aladdin Scientific
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ELSA BIOTECHNOLOGY CO.,LTD. 15261860116 sales@elsa-biotech.com China 99 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 4182 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8014 62

N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride Spectrum

AZ 10606120 dihydrochloride N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamidedihydrochloride N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]-2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride,AZ 10606120 dihydrochloride AZ 10606120 Dihydrochloride (~90%) AZ-10606120) AZ10606120 dihydrochloride (AZ 10606120 2-(Adamantan-1-yl)-N-(2-((2-((2-hydroxyethyl)amino)ethyl)amino)quinolin-5-yl)acetamide dihydrochloride P2X Receptor,AZ-10606120 dihydrochloride,Inhibitor,P2XRs,AZ10606120 dihydrochloride,inhibit,AZ10606120,AZ 10606120,AZ-10606120 AZ 10606120 (hydrochloride) 607378-18-7 C25H34N4O22HCl