ChemicalBook >> CAS DataBase List >>2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
![2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Structure](CAS/20200331/GIF/177172-49-5.gif)
- CAS No.
- 177172-49-5
- Chemical Name:
- 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
- Synonyms
- R-568;NPS-R568;R 568 hydrochloride;Tecalcet HCl (KRN568;Tecalcet (Hydrochloride);R-568 hydrochloride >=95% (HPLC);2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride;(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride;3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, hydrochloride;Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-, hydrochloride (1:1)
- CBNumber:
- CB22518826
- Molecular Formula:
- C18H23Cl2NO
- Molecular Weight:
- 340.28732
- MDL Number:
- MFCD16038895
- MOL File:
- 177172-49-5.mol
- MSDS File:
- SDS
Last updated:2023-09-04 15:51:00
| Melting point | 183.3-184.4 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO : 50 mg/mL (146.93 mM; Need ultrasonic) |
| form | Powder |
| FDA UNII | 3HP28R98LC |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17415 | R-568 ≥98% | 177172-49-5 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17415 | R-568 ≥98% | 177172-49-5 | 5mg | $90 | 2024-03-01 | Buy |
| Cayman Chemical | 17415 | R-568 ≥98% | 177172-49-5 | 10mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 17415 | R-568 ≥98% | 177172-49-5 | 50mg | $704 | 2024-03-01 | Buy |
| Tocris | 3815 | R568hydrochloride ≥99%(HPLC) | 177172-49-5 | 50 | $685 | 2021-12-16 | Buy |
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Chemical Properties,Uses,Production
Description
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. R-568 is a calcimimetic compound that can allosterically activate or positively modulate the human CaSR. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR.
Uses
R 568 Hydrochloride is a calcimimetic, which prevents vascular remodeling in uremia.
Uses
Treatment of hyperparathyroidism and related disorders, such as hypercalcemia (reduction of PTH secretion through modulation of calcium ion receptors on parathyroid cells).
brand name
Norcalcin (Amgen).
storage
Desiccate at RT
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 40)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanaminehydrochloride
R 568 hydrochloride
Tecalcet (Hydrochloride)
R-568
Tecalcet HCl (KRN568
NPS-R568
R-568 hydrochloride >=95% (HPLC)
Benzenepropanamine, 2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-, hydrochloride (1:1)
3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, hydrochloride
(R)-3-(2-Chlorophenyl)-N-(1-(3-methoxyphenyl)ethyl)propan-1-amine hydrochloride
177172-49-5