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Seneciphylline N-oxide

CAS No.
38710-26-8
Chemical Name:
Seneciphylline N-oxide
Synonyms
Seneciphylline N-oxid;Seneciphylline N-oxide;[1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, 12-oxide, (3Z,6R,14aR,14bR)-
CBNumber:
CB22519999
Molecular Formula:
C18H23NO6
Molecular Weight:
349.38
MDL Number:
MFCD20260632
MOL File:
38710-26-8.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:38

Seneciphylline N-oxide Properties

storage temp. 2-8°C
pka 12.40±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330
Precautionary statements  P260-P262-P264-P280-P302+P352+P310-P304+P340+P310
RIDADR  UN 1544PSN1 6.1 / PGIII

Seneciphylline N-oxide price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL82632 Seneciphylline N-oxide phyproof Reference Substance 38710-26-8 5mg $594 2024-03-01 Buy
TRC S258705 Seneciphylline N-oxide 38710-26-8 1mg $185 2021-12-16 Buy
Biosynth Carbosynth FS161631 Seneciphylline n-oxide 38710-26-8 5mg $450 2021-12-16 Buy
Biorbyt Ltd orb594286 Seneciphylline N-Oxide 38710-26-8 5mg $591.6 2021-12-16 Buy
AK Scientific W1082 Seneciphylline N-oxide 38710-26-8 5mg $657 2021-12-16 Buy
Product number Packaging Price Buy
PHL82632 5mg $594 Buy
S258705 1mg $185 Buy
FS161631 5mg $450 Buy
orb594286 5mg $591.6 Buy
W1082 5mg $657 Buy

Seneciphylline N-oxide Chemical Properties,Uses,Production

Description

Spartioidine N-oxide is a pyrrolizine alkaloid that is 13,19-didehydrosenecionane carrying a hydroxy substituent at position 12, two oxo substituents at positions 11 and 16 and an N-oxido substituent. It has a role as a Jacobaea metabolite. It is a macrocyclic lactone, an olefinic compound, an organic heterotricyclic compound, a pyrrolizine alkaloid, a tertiary alcohol and a tertiary amine oxide. It derives from a spartioidine.

Occurance

Seneciphylline N-oxide is a pyrrolizidine alkaloid that is naturally found in the extracts of Adenostyles alliariae, a plant that is native to the western Alps. Seneciphylline N-oxide is highly toxic to mammals and is also a suspected mutagen.

Uses

Seneciphylline N-oxide is a pyrrolizidine alkaloid that is naturally found in the extracts of Adenostyles alliariae, a plant that is native to the western Alps. Seneciphylline N-oxide is highly toxic to mammals and is also a suspected mutagen.

Definition

ChEBI: Spartioidine N-oxide is a pyrrolizine alkaloid that is 13,19-didehydrosenecionane carrying a hydroxy substituent at position 12, two oxo substituents at positions 11 and 16 and an N-oxido substituent. It has a role as a Jacobaea metabolite. It is a macrocyclic lactone, an olefinic compound, an organic heterotricyclic compound, a pyrrolizine alkaloid, a tertiary alcohol and a tertiary amine oxide. It is functionally related to a spartioidine.

General Description

Seneciphylline-N-oxide is a pyrrolizidine alkaloid isolated from Senecio vulgaris. Pyrrolizidine alkaloids are secondary metabolites, produced by several plant species as protection against insect herbivores. Approximately 6000 plant species worldwide may contain pyrrolizidine alkaloids. They are mainly found in the families of the Boraginaceae, Asteraceae and Fabaceae. The PA-content depends on several factors (species, plant organ, harvest, storage, extraction procedures). Contents vary from trace amounts up to 19 % based on dry weight. These alkaloids occur in two forms, as tertiary base PAs and their N-oxide (PANO).

Biological Activity

Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae).

Source

They are common food contaminants in herbs, tea, salad, leafy vegetables and honey. Feed can be contaminated so that the plant products find their way in the food chain indirectly also over meat, milk and eggs. Pyrrolizidine alkaloids have adverse health effects and were classified as genotoxic, carcinogen and hepatotoxic.

Seneciphylline N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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Chengdu Biopurify Phytochemicals Ltd. +86-028-82633397 18982077548 cwb1@biopurify.cn China 2376 60
Seneciphylline N-oxide Seneciphylline N-oxid [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-methyl-5-methylene-, 12-oxide, (3Z,6R,14aR,14bR)- 38710-26-8 38710-26-2