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MK8245

MK8245 Structure
MK8245 structure
CAS No.
1030612-90-8
Chemical Name:
MK8245
Synonyms
CS-1662;]-5-isoxazoL;]-2H-tetrazoL;MK 8245;MK8245;e-2-acetic acid;MK8245 USP/EP/BP;5-[3-[4-(2-Bromo-5-fL;MK8245;MK-8245;MK 8245;uorophenoxy)-1-piperidinyL;5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid
CBNumber:
CB22546432
Molecular Formula:
C17H16BrFN6O4
Molecular Weight:
467.25
MDL Number:
MFCD20039622
MOL File:
1030612-90-8.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:04
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MK8245 Properties

Boiling point 698.3±65.0 °C(Predicted)
Density 1.82
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility ≥23.35 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form solid
pka 2.85±0.10(Predicted)
FDA UNII 537E7QE8LX

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Danger
Hazard statements  H242
Precautionary statements  P210-P234-P235-P240-P370+P378-P403

MK8245 price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 901744 2-(5-(3-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid 1030612-90-8 100MG $114 2023-06-20 Buy
Cayman Chemical 29421 MK-8245 1030612-90-8 1mg $68 2024-03-01 Buy
Cayman Chemical 29421 MK-8245 1030612-90-8 25mg $836 2024-03-01 Buy
Cayman Chemical 29421 MK-8245 1030612-90-8 5mg $268 2024-03-01 Buy
Cayman Chemical 29421 MK-8245 1030612-90-8 10mg $435 2024-03-01 Buy
Product number Packaging Price Buy
901744 100MG $114 Buy
29421 1mg $68 Buy
29421 25mg $836 Buy
29421 5mg $268 Buy
29421 10mg $435 Buy

MK8245 Chemical Properties,Uses,Production

Description

MK-8245 is a liver-targeted inhibitor of stearoyl-CoA desaturase (SCD; IC50s = 3, 3, and 1 nM for rat, mouse, and human SCD1, respectively). It is selective for SCD1 over Δ5- and Δ6-desaturases (IC50s = >100,000 nM). MK-8245 (20-60 mg/kg) reduces the hepatic, but not Harderian gland, ratio of oleic acid to stearic acid, a marker of chronic SCD activity, and blood glucose levels, without inducing the formation of skin lesions or eye squinting behavior, in a mouse model of high-fat diet-induced obesity. It also inhibits hepatitis C virus (HCV) replication without inducing cytotoxicity in LucNeo2 cells (IC50 = 39.8 nM).

Uses

This product is Informer compound X9 of the Aryl Halide Chemistry Informer Library developed by chemists at Merck & Co., Inc., Kenilworth, NJ, U.S., which contains 18 drug-like molecules representative of those encountered in complex synthesis. By screening a new reaction against the Informer Library, chemists can directly compare and analyse a reaction′s successes and shortcomings among different methods and various research teams. It may also be used to facilitate deeper method development for performance or utility.

target

SCD1 (human)

References

[1] oballa rm, belair l, black wc, bleasby k, chan cc, desroches c, du x, gordon r, guay j, guiral s, hafey mj, hamelin e, huang z, kennedy b, lachance n, landry f, li cs, mancini j, normandin d, pocai a, powell da, ramtohul yk, skorey k, srensen d, sturkenboom w, styhler a, waddleton dm, wang h, wong s, xu l, zhang l. development of a liver-targeted stearoyl-coa desaturase (scd) inhibitor (mk-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. j med chem. 2011 jul 28;54(14):5082-96.
[2] lachance n, guiral s, huang z, leclerc jp, li cs, oballa rm, ramtohul yk, wang h, wu j, zhang l. discovery of potent and liver-selective stearoyl-coa desaturase (scd) inhibitors in an acyclic linker series. bioorg med chem lett. 2012 jan 1;22(1):623-7.

MK8245 synthesis

5382-16-1
1030612-90-8
Synthesis of MK8245 from 4-Hydroxypiperidine

MK8245 Preparation Products And Raw materials

Raw materials

3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazole-5-carbonitrile 3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazole-5-carboxamide tert-butyl2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetate 3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)-4,5-dihydroisoxazole-5-carboxamide 4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine
Piperidine, 4-(2-bromo-5-fluorophenoxy)- 2-Bromo-5-fluorophenol 4-Hydroxypiperidine N-BOC-4-Hydroxypiperidine 1-Bromo-2,4-difluorobenzene
Ethyl bromoacetate

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Preparation Products

MK8245 Suppliers

Global( 85)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29322 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd. 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58

View Lastest Price from MK8245 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MK8245 pictures 2020-01-17 MK8245
1030612-90-8
 US $3.00 / KG 1KG 98% 1kg,5kg,50kg Career Henan Chemical Co
  • MK8245 pictures
  • MK8245
    1030612-90-8
  • US $3.00 / KG
  • 98%
  • Career Henan Chemical Co

MK8245 Spectrum

MK8245(1030612-90-8)1HNMR

1030612-90-8(MK8245)Related Search:

PI-103 Conivaptan hydrochloride ABT-199 MG-132 Olaparib
Canertinib

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5-[3-[4-(2-Bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]-2H-tetrazole-2-acetic acid 2-(5-(3-(4-(2-broMo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid MK 8245;MK8245 MK8245;MK-8245;MK 8245 CS-1662 ]-2H-tetrazoL ]-5-isoxazoL 5-[3-[4-(2-Bromo-5-fL e-2-acetic acid uorophenoxy)-1-piperidinyL 2H-Tetrazole-2-acetic acid, 5-[3-[4-(2-bromo-5-fluorophenoxy)-1-piperidinyl]-5-isoxazolyl]- MK8245 USP/EP/BP 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]aceticaci 1030612-90-8 C17H16BrFN6O4 Inhibitors Inhibitor