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4-Hydroxy-3-nitrobenzotrifluoride

4-Hydroxy-3-nitrobenzotrifluoride structure

CAS No.: 400-99-7

Chemical Name:: 4-Hydroxy-3-nitrobenzotrifluoride

Synonyms: 4-Hydroxy-3-nitroben;alpha,alpha,alpha-trifluoro-2;2-nitro-4-trifluoromethlphenol;5-Nitro-2-trifluoromethyl-phenol;2-Nitro-4-(trifluormethyl)phenol;4-HYDROXY-3-NITROBENZOTRIFLUORIDE;2-nitro-4-(trifluoromethyl)-pheno;2-NITRO-4-(TRIFLUOROMETHYL)PHENOL;4-HYDROXY-3-NITROBENZOTRIFLUOROIDE;3-nitro-4-hydroxy-benzotrifluoride

CBNumber:: CB2254964

Molecular Formula:: C7H4F3NO3

Molecular Weight:: 207.11

MDL Number:: MFCD00009791

MOL File:: 400-99-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
2-Nitro-4-(trifluoromethyl)phenol 99%	238759	1G	$49
2-Nitro-4-(trifluoromethyl)phenol >98.0%(GC)(T)	N0779	1g	$46
2-Nitro-4-(trifluoromethyl)phenol >98.0%(GC)(T)	N0779	5g	$148
2-Nitro-4-(trifluoromethyl)phenol	N900803	50mg	$60
4-Hydroxy-3-nitrobenzotrifluoride 97%	001467	5g	$77
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4-Hydroxy-3-nitrobenzotrifluoride Properties

Boiling point	92-94 °C12 mm Hg(lit.)
Density	1.473 g/mL at 25 °C(lit.)
refractive index	n20/D 1.504(lit.)
Flash point	203 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
pka	5.53±0.14(Predicted)
color	Yellow to orange
BRN	2215510
CAS DataBase Reference	400-99-7(CAS DataBase Reference)
FDA UNII	CU9AQU8UAL
EPA Substance Registry System	Phenol, 2-nitro-4-(trifluoromethyl)- (400-99-7)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280a-P304+P340-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36

WGK Germany

RTECS

GP2984950

TSCA

HazardClass

IRRITANT

HS Code

29089990

Toxicity

LD50 ipr-mus: 800 mg/kg JPMSAE 57,1763,68

NFPA 704

	1
2		0

4-Hydroxy-3-nitrobenzotrifluoride price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	238759	2-Nitro-4-(trifluoromethyl)phenol 99%	400-99-7	1G	$49	2023-01-07	Buy
TCI Chemical	N0779	2-Nitro-4-(trifluoromethyl)phenol >98.0%(GC)(T)	400-99-7	1g	$46	2025-07-31	Buy
TCI Chemical	N0779	2-Nitro-4-(trifluoromethyl)phenol >98.0%(GC)(T)	400-99-7	5g	$148	2025-07-31	Buy
TRC	N900803	2-Nitro-4-(trifluoromethyl)phenol	400-99-7	50mg	$60	2021-12-16	Buy
Matrix Scientific	001467	4-Hydroxy-3-nitrobenzotrifluoride 97%	400-99-7	5g	$77	2021-12-16	Buy

Product number	Packaging	Price	Buy
238759	1G	$49	Buy
N0779	1g	$46	Buy
N0779	5g	$148	Buy
N900803	50mg	$60	Buy
001467	5g	$77	Buy

4-Hydroxy-3-nitrobenzotrifluoride Chemical Properties,Uses,Production

Uses

2-Nitro-4-(trifluoromethyl)phenol has been used in the synthesis of 2-methyl-2-[2-nitro-4-(trifluoromethyl)phenoxy]propionic acid ethyl ester.

General Description

2-Nitro-4-(trifluoromethyl)phenol is the major product of solution phase photodecomposition of fluorodifen.

Safety Profile

Moderately toxic byintraperitoneal route. When heated to decomposition itemits toxic vapors of NOx and Fí.

Synthesis

139-07-1

121-17-5

400-99-7

Example 1: 400 mL of methanol, 20 g of dodecyldimethylbenzylammonium chloride and 180 g of 4-chloro-3-nitrobenzotrifluoride were added to a reaction flask with stirring turned on. Subsequently, 400 g of 50% sodium hydroxide solution was slowly added dropwise, with the dropwise acceleration controlled to raise the reaction temperature to 70°C in about 20 minutes. The reaction mixture was continued stirring at 65°C for 4 hours. Upon completion of the reaction, the mixture was cooled in an ice water bath and the pH was adjusted with concentrated hydrochloric acid to 3. 2-Nitro-4-trifluoromethylphenol was isolated by steam distillation, and about 50 mL of concentrated hydrochloric acid was added to the receiver to facilitate phase separation. After gas chromatographic analysis, 156 g of 2-nitro-4-trifluoromethylphenol was obtained with a purity of >98.5% and a yield of 91% of the theoretical value. The boiling point of the product was 92 °C-95 °C (15 mmHg) and the refractive index nD20 was 1.5020.

References

[1] Patent: US4225731, 1980, A

4-Hydroxy-3-nitrobenzotrifluoride synthesis

Synthesis of 4-Hydroxy-3-nitrobenzotrifluoride from Dodecyldimethylbenzylammonium chloride and 4-Chloro-3-nitrobenzotrifluoride

4-Hydroxy-3-nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

4-Amino-3-nitrobenzotrifluoride Sodium hydroxide Hydrochloric acid 4-Chloro-3-nitrobenzotrifluoride Methanol

2-Methoxyethanol 4-Trifluoromethylphenol Dodecyldimethylbenzylammonium chloride

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Preparation Products

4-Fluoro-3-nitrobenzotrifluoride 2-amino-alpha,alpha,alpha-trifluoro-p-creso BUTTPARK 120\07-77

4-Hydroxy-3-nitrobenzotrifluoride Suppliers

Global( 222)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8768	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3588	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29847	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 4-Hydroxy-3-nitrobenzotrifluoride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-03	4-Hydroxy-3-nitrobenzotrifluoride 400-99-7	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-01-03	4-Hydroxy-3-nitrobenzotrifluoride 400-99-7	US $0.00-0.00 / KG	50mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2024-07-26	4-Hydroxy-3-nitrobenzotrifluoride 400-99-7	US $1.00-12.00 / KG	1KG	99%	1000KG	Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-3-nitrobenzotrifluoride
400-99-7
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Hydroxy-3-nitrobenzotrifluoride
400-99-7
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-3-nitrobenzotrifluoride
400-99-7
US $1.00-12.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-Hydroxy-3-nitrobenzotrifluoride Spectrum

4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)MS 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)¹HNMR 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)¹³CNMR 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)IR1 4-Hydroxy-3-nitrobenzotrifluoride(400-99-7)Raman

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2-NITRO-4-(TRIFLUOROMETHYL)PHENOL 2-nitro-4-(trifluoromethyl)-pheno 4-HYDROXY-3-NITROBENZOTRIFLUORIDE 4-HYDROXY-3-NITROBENZOTRIFLUOROIDE 2-nitro-alpha,alpha,alpha-trifluoro-p-creso 2-nitro-alpha,alpha,alpha-trifluoro-p-cresol alpha,alpha,alpha-trifluoro-2 5-Nitro-2-trifluoromethyl-phenol 4-Hydroxy-3-nitroben alpha,alpha,alpha-trifluoro-2-nitro-p-cresol 4-Hydroxy-3-nitrobenzotrifluoride 97% 4-Hydroxy-3-nitrobenzotrifluoride97% 2-Nitro-4-(trifluoromethyl)phenol, 2-Nitro-alpha,alpha,alpha-trifluoro-p-cresol 3-nitro-4-hydroxy-benzotrifluoride 2-Nitro-4-(trifluoroMethyl)phenol, 97+% 2-Nitro-4-(trifluormethyl)phenol 2-Nitro-4-(trifluoromethyl)phenol> Phenol, 2-nitro-4-(trifluoromethyl)- 2-nitro-4-trifluoromethlphenol 400-99-7 Oxygen Compounds Phenols Organic Building Blocks Building Blocks Phenol&Thiophenol&Mercaptan Organic Building Blocks Oxygen Compounds Phenols