Amiodarone-D4 HCl
- CAS No.
- 1216715-80-8
- Chemical Name:
- Amiodarone-D4 HCl
- Synonyms
- Prosulfocarb Impurity 3-d10;Amiodarone hydrochloride salt;[2H4]-Amiodarone Hydrochloride;2H4]-Amiodarone hydrochloride salt;Amiodarone-D4 hydrochloride solution;AMIODARONE HCL (D4, 98%) 100 UG/ML IN METHANOL (AS FREE BASE);(2-butyl-1-benzofuran-3-yl)-[3,5-diiodo-4-[1,1,2,2-tetradeuterio-2-(diethylamino)ethoxy]phenyl]methanone:hydrochloride;Amiodarone D4 HydrochlorideQ: What is Amiodarone D4 Hydrochloride Q: What is the CAS Number of Amiodarone D4 Hydrochloride Q: What is the storage condition of Amiodarone D4 Hydrochloride Q: What are the applications of Amiodarone D4 Hydrochloride
- CBNumber:
- CB22560799
- Molecular Formula:
- C25H30ClI2NO3
- Molecular Weight:
- 681.78
- MDL Number:
- MFCD08064189
- MOL File:
- 1216715-80-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25 | |||||||||
| Safety Statements | 7-16-36/37-45 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
Amiodarone-D4 HCl price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A-083 | Amiodarone-D4 hydrochloride solution 100?μg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 1216715-80-8 | 1ML | $238 | 2024-03-01 | Buy |
| Cayman Chemical | 10010668 | Amiodarone-d4 (hydrochloride) ≥99% deuterated forms (d1-d4) | 1216715-80-8 | 1mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 10010668 | Amiodarone-d4 (hydrochloride) ≥99% deuterated forms (d1-d4) | 1216715-80-8 | 5mg | $724 | 2024-03-01 | Buy |
| TRC | A632952 | Amiodarone-d4Hydrochloride | 1216715-80-8 | 25mg | $1390 | 2021-12-16 | Buy |
| TRC | A632952 | Amiodarone-d4Hydrochloride | 1216715-80-8 | 2.5mg | $180 | 2021-12-16 | Buy |
Amiodarone-D4 HCl Chemical Properties,Uses,Production
Description
Amiodarone-d4 is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents. It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50 value of 1 μM. In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid Δ8Δ7 isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 μM, respectively). It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 in vitro at low micromolar concentrations.
Uses
A Labelled non-selective ion channel blocker. Antiarrhythmic (class III).
General Description
A Certified Spiking Solution?and stable-labeled internal standard for use in therapeutic drug monitoring analyses by LC/MS. Amiodarone, an antiarrhythmic agent marketed as Pacerone?, Cordarone?, Aratac, Atlansil, is monitored by clinical labs to ensure patients remain within the drug′s therapeutic range.
Amiodarone-D4 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
Amiodarone-D4 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 3066 | 58 |
| Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9506 | 60 |
| Nanjing Haolv Biotechnology Co.,Ltd | 025-84622273 02584622273; | kexin.zhou@haolvbiotech.com | China | 3021 | 58 |
| Shenzhen Kaimingke Biotechnology Co., Ltd. | 181-26439142 18126439142 | 1144496688@QQ.COM | China | 170 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Shanghai Ruipu Medical Technology Co., Ltd | 15895968936 | 1018762393@qq.com | China | 8192 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 5042 | 58 |
| Manhag Testing Technology Co., Ltd | 020-020-3846236 17688849268 | 2443244976@qq.com | China | 7775 | 58 |
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