QRX 431
- CAS No.
- 211110-63-3
- Chemical Name:
- QRX 431
- Synonyms
- GC-1;NET44;EIEE3;QRX 431;Anti-GC1;Anti-OlfD;SobetiroMe;Anti-GW112;Anti-NET44;Anti-KIAA4294
- CBNumber:
- CB22628338
- Molecular Formula:
- C20H24O4
- Molecular Weight:
- 328.4
- MDL Number:
- MFCD19443713
- MOL File:
- 211110-63-3.mol
| Melting point | 122 - 124°C |
|---|---|
| Boiling point | 510.2±45.0 °C(Predicted) |
| Density | 1.152±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| pka | 3.22±0.10(Predicted) |
| form | powder |
| color | white to beige |
| InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
| FDA UNII | XQ31741E9Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
QRX 431 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1900 | Sobetirome ≥98% (HPLC) | 211110-63-3 | 5mg | $105 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1900 | Sobetirome ≥98% (HPLC) | 211110-63-3 | 25mg | $169.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | AV44041 | Anti-SLC25A22 antibody produced in rabbit IgG fraction of antiserum | 211110-63-3 | 100μL | $443 | 2024-03-01 | Buy |
| Tocris | 4554 | GC1 ≥98%(HPLC) | 211110-63-3 | 10 | $196 | 2021-12-16 | Buy |
| Usbiological | 255368 | GC 1 | 211110-63-3 | 10mg | $446 | 2021-12-16 | Buy |
QRX 431 Chemical Properties,Uses,Production
Uses
GC 1 is a high affinity thyroid receptor α (TRα) and TRβ agonist.
Definition
ChEBI: Sobetirome is a diarylmethane.
Biological Activity
sobetirome (3,5-dimethyl-4[(4'-hydroxy-3'-isopropylbenzyl)-phenoxy] acetic acid, also known as gc-1 and qrx-431, is a member of a class of compounds known as selective thyromimetics.it was firstly developed by thomas scanlan’s group at the university of california-san francisco (ucsf) in 1995 1.in cholesterol-fed rats, sobetirome was shown to lower plasma cholesterol in a dose-dependent manner by up to 75% of untreated controls. in hypercholesterolemic mice, sobetirome was failed to induce ldl receptor mrna expression. in different mouse models, sobetirome and t-0681 were shown to promote bile acid production and biliary sterol secretion. in cynomolgus monkeys, sobetirome was shown to reduce plasma cholesterol in a dose-dependent manner by up to 30%. both sobetirome and t-0681 were shown to increase hepatic expression of the hdl receptor (scavenger receptor-bi, sr-bi) in animals.in phase i
Biochem/physiol Actions
Sobetirome is also termed as 2-(4-(4-(benzyloxy)-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid/ GC-1. It has an inner-ring and negatively charged carboxylate groups at physiological pH. Sobetirome is considered as a cholesterol lowering agent in humans.
storage
Store at -20°C
References
1. tancevski i, demetz e, eller p. sobetirome: a selective thyromimetic for the treatment of dyslipidemia. recent pat cardiovasc drug discov. 2011 jan;6(1):16-9.
QRX 431 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |