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VX-661

CAS No.
1152311-62-0
Chemical Name:
VX-661
Synonyms
tezacaftor(VX661);(R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide;CS-956;VX-661;VX-661/VX661;VX661/Tezacaftor;VX-661 USP/EP/BP;VX 661; VX661;VX-661;VX 661;VX661;VX-661; TEZACAFTOR;Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4
CBNumber:
CB22632076
Molecular Formula:
C26H27F3N2O6
Molecular Weight:
520.5
MDL Number:
MFCD23106064
MOL File:
1152311-62-0.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:50

VX-661 Properties

Boiling point 610.8±55.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. Store at -20°C , stored under nitrogen
solubility ≥21.8 mg/mL in DMSO; insoluble in EtOH; ≥24.3 mg/mL in H2O
form solid
pka 13.99±0.20(Predicted)
FDA UNII 8RW88Y506K

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
NFPA 704
0
2 0

VX-661 price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21480 VX-661 ≥98% 1152311-62-0 5mg $62 2024-03-01 Buy
Cayman Chemical 21480 VX-661 ≥98% 1152311-62-0 10mg $115 2024-03-01 Buy
Cayman Chemical 21480 VX-661 ≥98% 1152311-62-0 25mg $239 2024-03-01 Buy
Cayman Chemical 21480 VX-661 ≥98% 1152311-62-0 50mg $448 2024-03-01 Buy
TRC T321510 Tezacaftor 1152311-62-0 1mg $55 2021-12-16 Buy
Product number Packaging Price Buy
21480 5mg $62 Buy
21480 10mg $115 Buy
21480 25mg $239 Buy
21480 50mg $448 Buy
T321510 1mg $55 Buy

VX-661 Chemical Properties,Uses,Production

Description

Tezacaftor (VX-661) is an oral medication for cystic fibrosis (CF) developed by Vertex Pharmaceuticals. In a combination therapy formulation called Symdeko (tezacaftor plus ivacaftor), it is approved in the U.S. and Canada for CF patients, ages 12 and older, who have two copies of the F508del mutation in the CFTR gene and one minimal function mutation. Symdeko is approved and marketed in the EU as Symkevi.Tezacaftor is not approved as a stand-alone treatment, but as part of a combination therapy.

Uses

Tezacaftor is used as a combination therapy with Ivacaftor for the treatment of patients with cystic fibrosis.

Definition

VX-661 is an investigational compound that promotes the maturation of delta F508 mutants of the cystic fibrosis transmembrane conductance regulator (CFTR). Delta F508 CFTR represents a class of CFTR mutation that is characterized by impaired processing of misfolded CFTR proteins and reduced accumulation of the protein at the cell surface. VX-661 is intended to facilitate trafficking of CFTR to the epithelial cell membrane. It may be combined with the CFTR potentiator ivacaftor (Item No. 15145) to stimulate both CFTR accumulation and opening at the apical epithelial surface.

Biochem/physiol Actions

VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis.

in vitro

VX-661, is CFTR modulator that is potentially useful for treatment of cystic fibrosis. VX-661 corrects F508del-CFTR trafficking and increases F508del-CFTR protein activity in vitro.

target

F508 del CFTR

References

[1] s. donaldson, j. pilewski, m. griese, q. dong, p.-s. lee, for the vx11–661-101 study group. ws7.3 vx-661, an investigational cftr corrector, in combination with ivacaftor, a cftr potentiator, in patients with cf and homozygous for the f508del-cftr mutation: interim analysis. journal of cystic fibrosis, volume 12, supplement 1, june 2013, page s14

VX-661 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 160)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
ENBRIDGE PHARMTECH CO., LTD.
+8613812269233 tinayang@enbridgepharm.com China 301 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12333 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Allfluoro pharmaceutical co. ltd.
021-26137118 +8615821363818 sales@allfluoro.com China 5791 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58

View Lastest Price from VX-661 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
VX-661 pictures 2021-11-15 VX-661
1152311-62-0
US $0.20 / g 1KG 99% 500ton/Month Qiuxian Baitai New Material Co., LTD
tezacaftor;VX661 pictures 2021-10-08 tezacaftor;VX661
1152311-62-0
US $0.00-0.00 / g 1g 98% 1000kgs Wuhan Nutra Biotechnology Co.,Ltd
VX-661 pictures 2019-07-06 VX-661
1152311-62-0
US $8.00 / kg 1kg 99% 100MT Career Henan Chemical Co
  • VX-661 pictures
  • VX-661
    1152311-62-0
  • US $0.20 / g
  • 99%
  • Qiuxian Baitai New Material Co., LTD
  • tezacaftor;VX661 pictures
  • tezacaftor;VX661
    1152311-62-0
  • US $0.00-0.00 / g
  • 98%
  • Wuhan Nutra Biotechnology Co.,Ltd
  • VX-661 pictures
  • VX-661
    1152311-62-0
  • US $8.00 / kg
  • 99%
  • Career Henan Chemical Co

VX-661 Spectrum

VX-661 VX-661/VX661 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]- 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-cyclopropanecarboxamide VX661 (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy- CS-956 VX661/Tezacaftor VX 661; VX661;VX-661 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)indol-5-yl]cyclopropane-1-carboxamide VX 661;VX661;VX-661; TEZACAFTOR Tezacaftor D4Q: What is Tezacaftor D4 Q: What is the CAS Number of Tezacaftor D4 VX-661 USP/EP/BP (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-Methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxaMide tezacaftor(VX661) inhibit,Tezacaftor,Inhibitor,VX-661,Cystic fibrosis transmembrane conductance regulator,Autophagy,VX 661,CFTR 1152311-62-0 C26H27F3N2O6 Inhibitors API