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JW55

JW55 structure

CAS No.: 664993-53-7

Chemical Name:: JW55

Synonyms: JW55;CS-1095;JW 55; JW-55;JW 55, >=98%;Tankyrase1/2 Inhibitor IV, JW55;Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem;N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide

CBNumber:: CB22645126

Molecular Formula:: C25H26N2O5

Molecular Weight:: 434.48

MDL Number:: MFCD03863265

MOL File:: 664993-53-7.mol

Last updated:2023-06-30 15:45:59

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JW55 Properties

Boiling point	572.6±50.0 °C(Predicted)
Density	1.235±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO: soluble15mg/mL, clear
pka	12.41±0.70(Predicted)
form	powder
color	white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
WGK Germany	3

JW55 price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0630	JW55 ≥98% (HPLC)	664993-53-7	5mg	$119	2024-03-01	Buy
Sigma-Aldrich	575547	Tankyrase1/2 Inhibitor IV, JW55	664993-53-7	25mg	$245	2024-03-01	Buy
Cayman Chemical	16260	JW 55 ≥98%	664993-53-7	5mg	$68	2024-03-01	Buy
Cayman Chemical	16260	JW 55 ≥98%	664993-53-7	10mg	$121	2024-03-01	Buy
Sigma-Aldrich	SML0630	JW55 ≥98% (HPLC)	664993-53-7	25mg	$428	2022-05-15	Buy

Product number	Packaging	Price	Buy
SML0630	5mg	$119	Buy
575547	25mg	$245	Buy
16260	5mg	$68	Buy
16260	10mg	$121	Buy
SML0630	25mg	$428	Buy

JW55 Chemical Properties,Uses,Production

Description

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC₅₀s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC₅₀ = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.

Uses

JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

Definition

ChEBI: N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamide is a member of furans and an aromatic amide.

storage

Store at +4°C

References

[1] waaler j, machon o, tumova l, dinh h, korinek v, wilson sr, paulsen je, pedersen nm, eide tj, machonova o, gradl d, voronkov a, von kries jp, krauss s. a novel tankyrase inhibitor decreases canonical wnt signaling in colon carcinoma cells and reduces tumor growth in conditional apc mutant mice. cancer res. 2012;72(11):2822-32.

JW55 synthesis

Synthesis of JW55 from 2-Furoyl chloride

JW55 Preparation Products And Raw materials

Raw materials

methyl 4-(furan-2-carboxamido)benzoate 4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-carbonitrile 1-[4-(4-METHOXYPHENYL)TETRAHYDRO-2H-PYRAN-4-YL]METHANAMINE Methyl 4-aminobenzoate 2-Furoyl chloride

4-Methoxybenzyl cyanide

1of2

Preparation Products

JW55 Suppliers

Global( 109)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58

View Lastest Price from JW55 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	JW55 664993-53-7	US $1.00 / KG	1KG	98-100%	1000kg	Career Henan Chemical Co

JW55
664993-53-7
US $1.00 / KG
98-100%
Career Henan Chemical Co

JW55 Spectrum

JW55(664993-53-7)¹HNMR

JW55 N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide N-[4-[[4-(4-METHOXYPHENYL)OXAN-4-YL]METHYLCARBAMOYL]PHENYL]FURAN-2-CARBOXAMIDE N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide JW55 N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamide JW 55, >=98% N-(4-(((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)phenyl)furan-2-carboxamid Tankyrase1/2 Inhibitor IV, JW55 Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem JW 55; JW-55 CS-1095 2-Furancarboxamide, N-[4-[[[[tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]- 664993-53-7 Inhibitors Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals