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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE structure

CAS No.: 85416-75-7

Chemical Name:: (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE

Synonyms: CS-1181;(?)-Rolipram;(-)-Rolipram;(R)-(-)-ROLIPRAM;(S)-(+)-ROLIPRAM;Rolipram (R)-(-)-;(R)-(-)-Rolipram;(R)-ROLIPRAM;(-)-ROLIPRAM;4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone;(4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

CBNumber:: CB2264846

Molecular Formula:: C16H21NO3

Molecular Weight:: 275.34

MDL Number:: MFCD03093860

MOL File:: 85416-75-7.mol

Last updated:2023-06-30 15:45:59

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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Properties

Melting point	132.0 to 136.0 °C
Boiling point	472.7±45.0 °C(Predicted)
Density	1.155±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	16.02±0.40(Predicted)
form	White to off-white solid.
color	Off-White
FDA UNII	DPX51KUP08

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
HS Code	2933.79.8500
HazardClass	IRRITANT

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	R0182	(R)-(-)-Rolipram >98.0%(HPLC)	85416-75-7	10mg	$158	2024-03-01	Buy
TCI Chemical	R0182	(R)-(-)-Rolipram >98.0%(HPLC)	85416-75-7	50mg	$549	2024-03-01	Buy
Tocris	1349	(R)-(-)-Rolipram ≥98%(HPLC)	85416-75-7	50	$876	2021-12-16	Buy
Tocris	1349	(R)-(-)-Rolipram ≥98%(HPLC)	85416-75-7	10	$212	2021-12-16	Buy
TRC	R640043	R-(-)-Rolipram	85416-75-7	5mg	$140	2021-12-16	Buy

Product number	Packaging	Price	Buy
R0182	10mg	$158	Buy
R0182	50mg	$549	Buy
1349	50	$876	Buy
1349	10	$212	Buy
R640043	5mg	$140	Buy

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Chemical Properties,Uses,Production

Uses

R-(-)-Rolipram is a phosphodiesterase IV (PDE4) inhibitor and anti-inflammatory agent with some antidepressant activity. It is the R isomer of (±)-Rolipram (R640040). Potent PDE4 inhibitor.

Definition

ChEBI: (-)-rolipram is the (R)-enantiomer of rolipram. It is an enantiomer of a (+)-rolipram.

Biological Activity

More active enantiomer of the PDE4 inhibitor rolipram (4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one ); 2-10-fold more potent than the S-(+) enantiomer ((4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one ). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

storage

Room temperature

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE synthesis

Synthesis of (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE from (E)-2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene and Dimethyl malonate

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Preparation Products And Raw materials

Raw materials

(E)-2-(cyclopentyloxy)-1-methoxy-4-(2-nitrovinyl)benzene S- (+)-Rolipram Dimethyl malonate

Preparation Products

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Alfa Chemistry		info@alfa-chemistry.com	United States	2344	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	7433	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Alfa Chemistry	58
InvivoChem	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	58
LEAPCHEM CO., LTD.	58
Jilin Chinese Academy of Sciences-yanshen Technology	58

View Lastest Price from (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-01-06	(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE 85416-75-7	US $1.00 / g	1g	85.0-99.8%	20ton	Career Henan Chemica Co

(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE
85416-75-7
US $1.00 / g
85.0-99.8%
Career Henan Chemica Co

85416-75-7((4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE)Related Search:

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Pentoxifylline AG 1295 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE EHNA HYDROCHLORIDE 4-(4'-Methoxyphenyl)-2-pyrrolidinone

4-(3'-Methoxyphenyl)-2-pyrrolidinone (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE 1-(4-bromobenzyl)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one

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(4R)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE (S)-(+)-ROLIPRAM (R)-(-)-ROLIPRAM (4R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidine-2-one Rolipram (R)-(-)- (4R)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one (R)-(-)-Rolipram 4-[3-(cyclopentoxy)-4-methoxy-phenyl]-2-pyrrolidone (R)-4-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one CS-1181 (R)-ROLIPRAM;(-)-ROLIPRAM 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)- (?)-Rolipram (-)-Rolipram Inhibitor,inhibit,Phosphodiesterase (PDE),(R)()Rolipram,(R) ( ) Rolipram 85416-75-7 Signalling Cyclic Nucleotide related