ChemicalBook >> CAS DataBase List >>PFI-1
PFI-1
- CAS No.
- 1403764-72-6
- Chemical Name:
- PFI-1
- Synonyms
- PFI-1;CS-709;PFI-1cas;PF-6405761;PFI 1;PFI1;PF-06405761;PFI-1 USP/EP/BP;PFI-1 (PF-6405761);PFI-1 (PF-06405761);PFI-1;PFI-1;PFI 1;PFI1
- CBNumber:
- CB22655765
- Molecular Formula:
- C16H17N3O4S
- Molecular Weight:
- 347.39
- MDL Number:
- MFCD22580416
- MOL File:
- 1403764-72-6.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
PFI-1 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0352 | PFI-1 ≥98% (HPLC) | 1403764-72-6 | 5mg | $122 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0352 | PFI-1 ≥98% (HPLC) | 1403764-72-6 | 25mg | $393 | 2024-03-01 | Buy |
| Cayman Chemical | 11155 | PFI-1 ≥98% | 1403764-72-6 | 1mg | $38 | 2024-03-01 | Buy |
| Cayman Chemical | 11155 | PFI-1 ≥98% | 1403764-72-6 | 5mg | $104 | 2024-03-01 | Buy |
| Cayman Chemical | 11155 | PFI-1 ≥98% | 1403764-72-6 | 10mg | $166 | 2024-03-01 | Buy |
PFI-1 Chemical Properties,Uses,Production
Description
PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells.
Uses
PFI-1 is used as a selective protein interaction inhibitor targetting BET bromodomains, used as regulators required for efficient expression of several growth promoting and anti-apoptotic genes.
Definition
ChEBI: 2-methoxy-N-(3-methyl-2-oxo-1,4-dihydroquinazolin-6-yl)benzenesulfonamide is a member of quinazolines.
storage
Store at RT
PFI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 120)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9633 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
1403764-72-6(PFI-1)Related Search:
PFI-1
PFI-1 (PF-6405761)
PFI-1 (PF-06405761)
PF-06405761
Benzenesulfonamide, 2-methoxy-N-(1,2,3,4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl)-
2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide PFI-1 (PF-6405761)
2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydro-quinazolin-6-yl)-bezenesulfonamide
PFI-1;PFI-1;PFI 1;PFI1
PFI 1;PFI1
CS-709
PF-6405761
PFI-1 USP/EP/BP
PFI-1cas
PFI1 PFI-1 PF-06405761 PF06405761
Inhibitor,inhibit,Apoptosis,PFI-1,Autophagy,Epigenetic Reader Domain
1403764-72-6
Inhibitors
Inhibitor