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indoleaMine-2,3-dioxygenase inhibitor INCB024360

indoleaMine-2,3-dioxygenase inhibitor INCB024360 structure

CAS No.: 914471-09-3

Chemical Name:: indoleaMine-2,3-dioxygenase inhibitor INCB024360

Synonyms: IDO5L;CS-1034;IDO-IN-2;INCB14943;INCB024360;INCB-24360;INCB-024360;INCB 024360;IDO inhibitor;4-diaminobutane

CBNumber:: CB22666639

Molecular Formula:: C9H7ClFN5O2

Molecular Weight:: 271.64

MDL Number:: MFCD28142835

MOL File:: 914471-09-3.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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indoleaMine-2,3-dioxygenase inhibitor INCB024360 Properties

Boiling point	504.7±60.0 °C(Predicted)
Density	1.78±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥13.55 mg/mL in DMSO
pka	7.54±0.69(Predicted)
form	Solid
FDA UNII	2HR315841W

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

indoleaMine-2,3-dioxygenase inhibitor INCB024360 price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.38256	IDO Inhibitor		10MG	$190	2024-03-01	Buy
Cayman Chemical	18265	INCB024360 analog ≥98%	914471-09-3	5mg	$66	2024-03-01	Buy
Cayman Chemical	18265	INCB024360 analog ≥98%	914471-09-3	1mg	$25	2021-12-16	Buy
Cayman Chemical	18265	INCB024360 analog ≥98%	914471-09-3	10mg	$117	2024-03-01	Buy
Cayman Chemical	18265	INCB024360 analog ≥98%	914471-09-3	25mg	$259	2024-03-01	Buy

Product number	Packaging	Price	Buy
5.38256	10MG	$190	Buy
18265	5mg	$66	Buy
18265	1mg	$25	Buy
18265	10mg	$117	Buy
18265	25mg	$259	Buy

indoleaMine-2,3-dioxygenase inhibitor INCB024360 Chemical Properties,Uses,Production

Description

Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).

In vitro

In IFN-γ–treated human HeLa cells, INCB024360 potently inhibits kynurenine production. INCB024360 also promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells.

In vivo

INCB024360 (100 mg/kg, p.o.), via IDO1 inhibition, suppresses kyn generation and tumor growth in immunocompetent, but not immunodeficient, mice. In mice bearing CT26 colon carcinoma, INCB024360 (100 mg/kg, p.o.) also inhibits the growth of IDO-expressing tumors by reducing kynurenine.

Uses

INCB024360 acts as a competitive inhibitor of (IDO1) indoleamine 2,3-dioxygenase showing effect in mouse melanoma models. IC50 = 67 nM

Biological Activity

incb024360 analogue is a potent and selective inhibitor of ido1 with ic50 value of 67 nm. [1]ido (indoleamine-pyrrole 2, 3-dioxygenase) is an enzyme which is encoded by the ido1 gene. ido is the rate-limiting and first enzyme of tryptophan which is one amino acid of human catabolism through kynurenine pathway. the decrease of l-tryptophan can cause halted growth of t cells as well as microbes. ido belongs to immunomodulatory enzyme. it is produced by some activated macrophages and immunoregulatory cells. ido is overexpressed in a wide range of cancer cells such as lung, prostatic, pancreatic, colorectal cancer. it is indentified to help cancer cells to escape the immune system by reducing the level of l-tryptophan in the microenvironment of cells.[2]in hela cells, incb024360 analogue selectively inhibited the activity of human ido1 with ic50 value of 19 nm. on the other hand, incb024360 analogue demonstrated little inhibition activity against tdo (tryptophan 2, 3-dioxygenase). in murine b16 cells, incb024360 analogue inhibited ido with ic50 value of 46 nm [1].in naive c57bl/6 mice, 100 mg/kg incb024360 analogue injected subcutaneously reduced kynurenine levels by >50% via inhibition of ido activity. in c57bl/6 mice bearing gm-csf- secreting b16 tumors, incb024360 analogue (25, 50, and 75 mg/kg b.i.d.) injected subcutaneously for 14 days dose-dependently inhibited tumor growth [1].

storage

Store at -20°C

References

[1]. yue ew1, douty b, wayland b, et al. discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. j med chem. 2009 dec 10;52(23):7364-7.
[2]. uyttenhove c, pilotte l, theate i, stroobant v, colau d, parmentier n, boon t, van den eynde bj: evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. nat med 2003, 9(10):1269-1274.

indoleaMine-2,3-dioxygenase inhibitor INCB024360 synthesis

Synthesis of indoleaMine-2,3-dioxygenase inhibitor INCB024360 from 3-Fluoroaniline and 1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy-

indoleaMine-2,3-dioxygenase inhibitor INCB024360 Preparation Products And Raw materials

Raw materials

1,2,5-Oxadiazole-3-carboxiMidoyl chloride, 4-aMino-N-hydroxy- 3-Fluoroaniline 3-Chloro-4-fluoroaniline

Preparation Products

indoleaMine-2,3-dioxygenase inhibitor INCB024360 Suppliers

Global( 130)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3791	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
WinWin Chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	13854	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
WinWin Chemical CO., Limited	58
Dideu Industries Group Limited	58

View Lastest Price from indoleaMine-2,3-dioxygenase inhibitor INCB024360 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-20	INCB024360 914471-09-3	US $0.00-0.00 / KG	5mg	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd
2021-07-02	IDO5L 914471-09-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	indoleaMine-2,3-dioxygenase inhibitor INCB024360 914471-09-3	US $8.00 / kg	1kg	99%	10tons	Career Henan Chemical Co

INCB024360
914471-09-3
US $0.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

IDO5L
914471-09-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

indoleaMine-2,3-dioxygenase inhibitor INCB024360
914471-09-3
US $8.00 / kg
99%
Career Henan Chemical Co

indoleaMine-2,3-dioxygenase inhibitor INCB024360 Spectrum

indoleaMine-2,3-dioxygenase inhibitor INCB024360(914471-09-3)¹HNMR

914471-09-3(indoleaMine-2,3-dioxygenase inhibitor INCB024360)Related Search:

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(4E)-4-[(3-chloro-4-fluoroanilino)-nitrosomethylidene]-1,2,5-oxadiazol-3-amine INCB 024360 INCB024360 INCB-024360 INCB-24360 indoleaMine-2,3-dioxygenase inhibitor INCB024360 INCB024360/INCB-024360 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide INCB024360 IDO-IN-2 INCB024360 analogue (E)-4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide IDO5L INCB024360 analog IDO inhibitor INCB024360 ANALOGUE;IDO5L INCB024360 500MG IDO-IN-2(1g 2000) N-(4-Aminobutyl)-1 N-(3-Aminopropyl)-1 4-diaminobutane indoleaMine-2,3-dioxygenase inhibitor INCB024360 USP/EP/BP 1,2,5-Oxadiazole-3-carboximidamide, 4-amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy- INCB024360-analog(IDO-IN-2) INCB 024360-analog - IDO inhibitor 5l indoleaMine-2,3-dioxygenase inhibitor INCB-024360; INCB 024360; INCB-24360; INDOLEAMINE-2;3-DIOXYGENASE INHIBITOR INCB024360 3-dioxygenase inhibitor INCB024360 INCB024360 analogue(IDO-IN-1) INCB14943 Epacadostat-analog CS-1034 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboxamidine 914471-09-3 C9H7ClFN5O2 Inhibitors