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SRPK inhibitor

SRPK inhibitor Structure
SRPK inhibitor structure
CAS No.
218156-96-8
Chemical Name:
SRPK inhibitor
Synonyms
CS-910;SRPIN340;SRPIN 340;SRPIN-340;SRPK inhibitor;SRPIN340, >=98%;SRPIN340 >=98% (HPLC);SRPK Inhibitor(SRPIN340);SRPIN340 (SRPK inhibitor);SRPIN 340; SRPIN-340; SRPK INHIBITOR
CBNumber:
CB22668305
Molecular Formula:
C18H18F3N3O
Molecular Weight:
349.35
MDL Number:
MFCD00116244
MOL File:
218156-96-8.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
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SRPK inhibitor Properties

Boiling point 395.9±42.0 °C(Predicted)
Density 1.306±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka 11.09±0.70(Predicted)
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

SRPK inhibitor price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1088 SRPIN340 ≥98% (HPLC) 218156-96-8 5mg $118 2024-03-01 Buy
Sigma-Aldrich SML1088 SRPIN340 ≥98% (HPLC) 218156-96-8 25mg $476 2024-03-01 Buy
Sigma-Aldrich 5.04293 SRPK Inhibitor, SRPIN340 - CAS 281856-96-8 - Calbiochem 218156-96-8 10mg $204 2023-01-07 Buy
Cayman Chemical 16284 SRPIN340 ≥95% 218156-96-8 1mg $32 2024-03-01 Buy
Cayman Chemical 16284 SRPIN340 ≥95% 218156-96-8 5mg $86 2024-03-01 Buy
Product number Packaging Price Buy
SML1088 5mg $118 Buy
SML1088 25mg $476 Buy
5.04293 10mg $204 Buy
16284 1mg $32 Buy
16284 5mg $86 Buy

SRPK inhibitor Chemical Properties,Uses,Production

Description

Serine/arginine-rich protein kinase 1 (SRPK1) targets proteins that contain multiple serine/arginine (SR) dipeptides, including SR-rich splicing factor 1, SRSF1. SRPIN340 is an isonicotinamide compound that inhibits SRPK1 (Ki = 0.89 μM). It is about 10-fold less effective against SRPK2 and does not inhibit the related SRPKs, Clk1 and Clk4. SRPIN340 suppresses the propagation of Sindbis virus in Vero cells and the replication of hepatitis C virus in Huh7/Rep-Feo-2a cells. By blocking SRPK1-mediated phosphorylation of SRSF1, SRPIN340 modulates alternative splicing of VEGF, reducing neovascularization both in cells and in animals.

Uses

SRPIN340 is a SRPK1 kinase inhibitor, which shows potential novel targeted therapeutic strategy in prostate cancer.

References

1) Fukuhara?et al.?(2006),?Utilization of host SR protein kinases and RNA-splicing machinery during viral replication; Proc. Natl. Acad. Sci. USA,?103?11329 2) Gammons?et al.?(2013),?SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity; Invest. Ophthalmol. Vis. Sci.,?54?5797 3) Gammons?et al.?(2014),?Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma; Br. J. Cancer,?111?477

SRPK inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

SRPK inhibitor Suppliers

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5738 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
TargetMol Chemicals Inc. 		58
Shenzhen Shengda Pharma Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Coresyn Pharmatech Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from SRPK inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SRPK inhibitor pictures 2019-09-06 SRPK inhibitor
218156-96-8
 US $1.00 / KG 1KG 98% 20kg Career Henan Chemical Co

SRPK inhibitor Spectrum

SRPK inhibitor(218156-96-8)1HNMR

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4-Pyridinecarboxamide, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]- N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340 SRPK inhibitor N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPIN 340 SRPIN340 SRPIN-340 SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoroMethyl)phenyl)isonicotinaMide N-[2-(1-Piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide SRPK Inhibitor(SRPIN340) SRPIN340, >=98% N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide CS-910 SRPIN 340; SRPIN-340; SRPK INHIBITOR SRPIN340 >=98% (HPLC) SRPIN340 (SRPK inhibitor) 218156-96-8 Inhibitors