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ZENIPLATIN

CAS No.
111490-36-9
Chemical Name:
ZENIPLATIN
Synonyms
ZENIPLATIN;Zeniplatinum;ZENIPLATIN USP/EP/BP;(sp-4-2)-[2,2-Bis(aminc~nethyl)-1,3-propanediol-N,N,][1,1-cyclobutanedicarboxylato(2-)-O,O’]platinum
CBNumber:
CB2267690
Molecular Formula:
C11H20N2O6Pt
Molecular Weight:
471.36
MDL Number:
MFCD00866466
MOL File:
111490-36-9.mol
Last updated:2022-12-21 16:56:50

ZENIPLATIN Properties

Melting point 210-212 °C
FDA UNII 40ZQ0A17IT

ZENIPLATIN price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0012816 ZENIPLATIN 95.00% 111490-36-9 5MG $504.98 2021-12-16 Buy
Product number Packaging Price Buy
API0012816 5MG $504.98 Buy

ZENIPLATIN Chemical Properties,Uses,Production

Originator

Zeniplatin,American Cyanamid (AHP)

Uses

Antineoplastic.

Manufacturing Process

The compound of 2,2-dibromomethyl-1,3-propanediol was prepared by the method M. Saivier (et al.), Can. J. Chem; 44, 1599 (1966).
A mixture of 13.1 g of 2,2-dibromomethyl-1,3-propanediol, 6.5 g of sodium azide and 750 ml of dimethylformamide was stirred and heated at 110°- 120°C for 20 h, then clarified and the filtrate evaporated. The residue was extracted three times with dichloromethane. The extracts were combined and evaporated, giving 13.65 g of 2,2-bis(azidomethyl)-1,3-propanediol, compound with dimethylformamide.
A 13.0 g portion of the 2,2-bis(azidomethyl)-1,3-propanediol was reduced with 0.1 g of platinum dioxide in ethanol, using 50 lb of hydrogen pressure for 20 h. The mixture was then filtered and the filtrate concentrated to dryness, giving 9.34 g of 2,2-bis(aminomethyl)-1,3-propanediol as a pale yellow oil.
A mixture of 1.34 g of 2,2-bis(aminomethyl)-1,3-propanediol, 4.15 g of potassium dichloroplatinate and 22 ml of water was stirred for 2 h, then cooled, the solid collected and washed three times with cold water. This solid was recrystallized from 60 ml of hot water, giving 890.0 mg of the desired [2,2-bis(aminomethyl)-1,3-propanediol-N,N']dichloroplatinum as beige crystals, melting point 223°-225°C (dec.).
A mixture of 0.8 g of [2,2-bis(aminomethyl)-1,3-propanediol- N,N']dichloroplatinum and 0.78 g of the disilver salt of 1,1-cyclobutane dicarboxylic acid in 50 ml of water was stirred in the dark overnight and then filtered. The filtrate was evaporated to dryness, giving 0.72 g of the desired [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[1,1'- cyclobutanedicarboxylato](2-)-O1,O1]platinum as a beige powder, melting point 202°-205°C (dec.).

Therapeutic Function

Antineoplastic

ZENIPLATIN Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2127 70
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Taixing Haichuan Biotechnology Co., Ltd. 14760821013 1816280386@qq.com China 9036 58

View Lastest Price from ZENIPLATIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZENIPLATIN USP/EP/BP pictures 2021-07-03 ZENIPLATIN USP/EP/BP
111490-36-9
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
(sp-4-2)-[2,2-Bis(aminc~nethyl)-1,3-propanediol-N,N,][1,1-cyclobutanedicarboxylato(2-)-O,O’]platinum ZENIPLATIN ZENIPLATIN USP/EP/BP Zeniplatinum 111490-36-9 C6H6O4PtC5H14N2O2