Isradipine | 75695-93-1

Isradipine Properties

Melting point	166-1680C
Boiling point	501.9±60.0 °C(Predicted)
Density	1.249±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ~26 mg/mL
form	solid
pka	2.56±0.70(Predicted)
color	yellow
Merck	14,5240
BCS Class	2/4
Stability	Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	HMJIYCCIJYRONP-UHFFFAOYSA-N
CAS DataBase Reference	75695-93-1(CAS DataBase Reference)
FDA UNII	YO1UK1S598
ATC code	C08CA03
NIST Chemistry Reference	Isradipine(75695-93-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H413
Precautionary statements	P501-P273
Safety Statements	22-24/25
WGK Germany	3
HS Code	2934990002

Isradipine price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I6658	Isradipine ≥98% (HPLC), solid	75695-93-1	5mg	$212	2024-03-01	Buy
Sigma-Aldrich	5.08507	Isradipine - CAS 75695-93-1 - Calbiochem A voltage gated calcium channel gating inhibitor of the dihydropyridine class.	75695-93-1	10MG	$142	2024-03-01	Buy
Sigma-Aldrich	1354207	Isradipine United States Pharmacopeia (USP) Reference Standard	75695-93-1	200mg	$375	2024-03-01	Buy
TCI Chemical	I0876	Isradipine >98.0%(HPLC)	75695-93-1	25mg	$157	2024-03-01	Buy
Alfa Aesar	J63920	Isradipine, 98+%	75695-93-1	10mg	$117.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
I6658	5mg	$212	Buy
5.08507	10MG	$142	Buy
1354207	200mg	$375	Buy
I0876	25mg	$157	Buy
J63920	10mg	$117.65	Buy

Isradipine Chemical Properties,Uses,Production

Description

Isradipine is a long-acting calcium blocker effective in the treatment of essential hypertension. The advantages of isradipine as compared with other dihydropyridine calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive heart failure or ischemic heart disease.

Chemical Properties

Yellow Solid

Originator

Sandoz (Switzerland)

Uses

nonsedating H1-antihistamine

Uses

Dihydropyridine calcium channel blocker. Antihypertensive; antianginal

Uses

Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.

Definition

ChEBI: Isradipine is an isopropyl ester, a methyl ester, a dihydropyridine and a benzoxadiazole.

brand name

Dynacirc (Reliant);Prescal.

General Description

Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.

Biological Activity

Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.

Biochem/physiol Actions

L-type calcium channel blocker (also referred to as dihydropyridine-type calcium channel blocker); antihypertensive.

storage

Room temperature

References

1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 3) Merck 14:5240

Isradipine Preparation Products And Raw materials

Raw materials

Isopropyl acetoacetate Benzofuroxan Methyl 3-aminocrotonate

Preparation Products

Isradipine Suppliers

Global( 272)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850 +86-13986145403	info@fortunachem.com	China	5988	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9339	58

Supplier	Advantage
Xiamen AmoyChem Co., Ltd	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Wuhan Fortuna Chemical Co., Ltd	58
Baoji Guokang Bio-Technology Co., Ltd.	58

View Lastest Price from Isradipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-02-09	Isradipine 75695-93-1	US $0.00 / G	1G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2021-11-02	Isradipine 75695-93-1	US $158.00 / g	10g	99%	1000kg	Baoji Guokang Healthchem co.,ltd
2021-08-07	Isradipine USP/EP/BP 75695-93-1	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

Isradipine
75695-93-1
US $0.00 / G
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Isradipine
75695-93-1
US $158.00 / g
99%
Baoji Guokang Healthchem co.,ltd

Isradipine USP/EP/BP
75695-93-1
US $1.10 / g
99.9%
Dideu Industries Group Limited

Isradipine Spectrum

Isradipine(75695-93-1)¹HNMR

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Isradipine Impurity 2（Isradipine EP Impurity B） Benzofuroxan 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID

1of4

PN-200-110 Presca Prescal 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic [chemical name] acid methyl 1-methylethyl ester Dynacrine Iomir Rebfiden 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester PN-200-100 [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine Isradipin Clivoten DynaCirc Esradin Isrodipine Lomir 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester Isradipine (200 mg) 3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Isradipine(Dynacirc) Isradipine API 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester Isradipine, >=99% 3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER CS-139 (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester Dynacirc CR PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR; Isradipine Solution, 100ppm Isradipine> Isradipine CRS 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Isradipine USP/EP/BP Isradipine (PN 200-110) IsradipineQ: What is Isradipine Q: What is the CAS Number of Isradipine Q: What is the storage condition of Isradipine Q: What are the applications of Isradipine 4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester Isradipine (1354207) Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 75695-93-1 75696-93-1 75695-63-1 C19H15N3O5D6 ALLEGRA Ion Channels Calcium channel Intermediates & Fine Chemicals Pharmaceuticals API