BLASTICIDIN S | 2079-00-7

BLASTICIDIN S Properties

Melting point	235°C
Boiling point	539.06°C (rough estimate)
alpha	D11 +108.4° (water)
Density	1.1690 (rough estimate)
vapor pressure	Low
refractive index	1.6910 (estimate)
solubility	DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: soluble
form	A solid
pka	2.4 (carboxyl), 4.6,8.0 and>12.5 (three bases)
Water Solubility	>30 g l^-1(20 °C)
Stability	Incompatible with strong oxidizing agents.
FDA UNII	83U64J9U23
EPA Substance Registry System	Blasticidin S (2079-00-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes

T+

Risk Statements

28

Safety Statements

24/25-36/37-45

RIDADR

3172

HazardClass

6.1(a)

PackingGroup

II

HS Code

29349990

Toxicity

LD50 i.v. in mice: 2.82 mg/kg (Takeuchi)

NFPA 704

	0
4		0

BLASTICIDIN S price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0008653	BLASTICIDIN S 95.00%	2079-00-7	50MG	$759.41	2021-12-16	Buy
American Custom Chemicals Corporation	API0008653	BLASTICIDIN S 95.00%	2079-00-7	100MG	$839.45	2021-12-16	Buy
American Custom Chemicals Corporation	API0008653	BLASTICIDIN S 95.00%	2079-00-7	250MG	$1086.86	2021-12-16	Buy
AHH	MT-48228	BlasticidinS 98%	2079-00-7	0.5g	$770	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0008653	50MG	$759.41	Buy
API0008653	100MG	$839.45	Buy
API0008653	250MG	$1086.86	Buy
MT-48228	0.5g	$770	Buy

BLASTICIDIN S Chemical Properties,Uses,Production

Description

Nucleoside antibiotic produced by Streptomyces griseochromogenes (1). Biosynthesized from cytosine, glucose, arginine, and methionine (2).

Uses

Blasticidin-S is used for the control of rice blast (PyricuZuria oryzae) by foliar application.

Uses

Blasticidin S is a nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations. Blasticidin S provided by BioAustralis is presented as the free base to avoid problems associated with the use of the hydrochloride.

Definition

ChEBI: A blasticidin that is an antibiotic obtained from Streptomyces griseochromogene.

Production Methods

Blasticidin S is produced by Streptomyces griseochromogenes, and has a wide range of antimicrobial activity (4). This antibiotic was utilized in the Far East beginning in 1961 against the rice blast pathogen Pyricularia oryzae, with effective control achieved at rates of 10–40 ppm (4).

General Description

Blasticidin S was found in the culture broth of Streptomyces griseochromogenes by Yonehara et al. of the University of Tokyo in 1958. It has a nucleoside-analogue structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. Blasticidin S has been used to protect rice plants.

Pharmacology

Inhibits protein synthesis both in eukaryotes and in prokaryotes (5,6). Interacts with ribosomal RNA in large subunit, interfering with the transpeptidation step. Inhibits cell-free protein synthesis in P. oryzae and Escherichia coli.

Metabolic pathway

Several blasticidin S-resistant microorganisms are found to produce blasticidin S deaminase which catalyzes the hydrolytic deamination of the cytosine moiety in blasticidin S to give a non-toxic deaminohydroxy derivative.

Metabolism

3H-blasticidin S administered to mice was excreted in the urine and feces within 24 h. Cytomycin and cytosin were identified as the main metabolites in and on rice plants, respectively (7). In soil, DT₅₀ < 5 d. Metabolized to nontoxic deaminohydroxy blasticidin S by Aspergillus sp. and resistant Bacillus cereus. Novel deaminase and coding genes, BSD and bsr, were isolated as selectable marker genes for genetic engineering (8).

Toxicity evaluation

Acute oral LD₅₀ for male rats: 56.8, female rats: 55.9, male mice: 51.9, and female mice: 60.1 mg/kg. Acute percutaneous LD₅₀ for rats >500 mg/kg. Eye: severe irritation.

Degradation

Blasticidin-S is obtained as white needle crystals which are very soluble in water. The compound is stable in the pH range 5-7 but it is unstable under alkaline conditions. It is readily degraded by sunlight when on the surface of rice plants with the main degradation product being cytosine (2) (Yamaguchi et al., 1972) as shown in Scheme 1.

BLASTICIDIN S Preparation Products And Raw materials

Raw materials

VEGETABLEPROTEIN Diphenylmethane streptomyces avermifilis BBK8 AMIKACIN SULFATE CREAM

Preparation Products

BLASTICIDIN S Suppliers

Global( 50)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9604	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29525	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12338	58
Shandong Xiya Chemical Co., Ltd.	4009903999 13395398332	sales@xiyashiji.com	China	20810	60
Raw material medicin reagent co.,Ltd	025-57798860	sales@njromanme.com	China	4534	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58
Dideu Industries Group Limited	58
LEAPCHEM CO., LTD.	58
Beijing HuaMeiHuLiBiological Chemical	58
Shandong Xiya Chemical Co., Ltd.	60
Raw material medicin reagent co.,Ltd	58
Lynnchem	58

View Lastest Price from BLASTICIDIN S manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-02	BLASTICIDIN S USP/EP/BP 2079-00-7	US $1.10 / g	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2020-05-26	Blasticidin S 2079-00-7	US $0.00-0.00 / Kg	1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2019-12-23	BLASTICIDIN S 2079-00-7	US $1.00 / KG	1KG	98	10t	Career Henan Chemical Co

BLASTICIDIN S USP/EP/BP
2079-00-7
US $1.10 / g
99.9%
Dideu Industries Group Limited

Blasticidin S
2079-00-7
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

BLASTICIDIN S
2079-00-7
US $1.00 / KG
98
Career Henan Chemical Co

2079-00-7(BLASTICIDIN S)Related Search:

Chlorothalonil DITHIANON DODECYLBENZENE DODECYLBENZENE Sulfamic acid

Dodecylbenzene BLASTICIDIN S H-BETA-ALA-BETA-ALA-OH Demethylblasticidin S BLASTICIDIN S HCL,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,BLASTICIDIN S HYDROCHLORIDE

Blasticidin H blasticidin A blasticidin S deaminase BLASTICIDIN S HCL UN2811- blasticidin S-acetyltransferase

Blasticidin S, HCl, Streptomyces griseochromogenes Blasticidin S sodium salt BLASTICIDIN S HCL,BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES,Blasticidin S benzylaminobenzenesulfonate Blasticidin

1of4

1(1’-Cytosinyl)-4-[L-3’-amino-5’(1’’-N-methylguanidino)valerlamino]1,2,3,4-te-tradeoxy-D-erythro-hex-2-enuronicacid Blas Blaes .beta.-D-erythro-Hex-2-enopyranuronic acid, 4-3-amino-5-(aminoiminomethyl)methylamino-1-oxopentylamino-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-, (S)- 1(1'-Cytosinyl)-4-[L-3'-amino-5'(1''-N-methylguanidino)valerlamino]1,2,3,4-te-tradeoxy-D-erythro-hex-2-enuronic acid bcs-3、bla-s Alkylate, "hard" Alkylbenzene (branched) Branched alkylbenzene Branched detergent alkylate Branched dodecylbenzene Detergent alkylate (branched) Dodecylbenzene (branched) (2S)-3β-[[(3S)-3-Amino-5-(1-methylguanidino)pentanoyl]amino]-6α-(4-amino-2-oxo-1(2H)-pyrimidinyl)-3,6-dihydro-2H-pyran-2α-carboxylic acid 4-[[(3S)-3-Amino-5-[[amino(imino)methyl]methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-2-hexenopyranuronic acid 4-[[(S)-3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-2-hexenopyranuronic acid Blastizidin s Blasticidin S Hydrochloride in buffer solutionLiquid Blasticidin S Hydrochloride (solid) 3-(3-amino-5-(1-methylguanidino)-1-oxopentylamino-6-(4-amino-2-oxo-2,3-dihydro-pyrimidin-1-yl)-2,3-dihydro-(6H)-pyran-2-carboxylic acid blasticidin-s S-[4-[3-amino-5-[(aminoiminomethyl) methylamino]-1-oxopentyl] amino]-1-[4-amino-2-oxo-1 (2H)-pyrimidinyl]-1,2,3,4-tetradeoxy-β-D-erythrohex-2-enopyranuronic acid Cytovarin, Bla-S, 21544, A83094C, NSC 91770 babs bcs-3 blastizidin cytovirin toabla-s Vlasticidins β-D-erythro-Hex-2-enopyranuronic acid, 4-[[(3S)-3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy- BLASTICIDIN S USP/EP/BP bab blasticidin BLASTICIDIN S 2079-00-7 C17H26N8O5ClH C17H26N8O5 FUNGICIDE