ChemicalBook >> CAS DataBase List >>UNC2025

UNC2025

CAS No.
1429881-91-3
Chemical Name:
UNC2025
Synonyms
CS-2109;UNC2025;mrx-6313;UNC2025 HCl;UNC2025;UNC 2025;UNC-2025; UNC2025; UNC 2025.;(1r,4r)-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimi;trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol;trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol;(1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
CBNumber:
CB22715676
Molecular Formula:
C28H40N6O
Molecular Weight:
476.66
MDL Number:
MFCD28142874
MOL File:
1429881-91-3.mol
Last updated:2023-07-12 16:47:00

UNC2025 Properties

Boiling point 677.5±65.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility ≥23.85 mg/mL in DMSO; insoluble in EtOH; ≥6.09 mg/mL in H2O with ultrasonic
form Powder
pka 14.63±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

UNC2025 price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16613 UNC2025 ≥98% 1429881-91-3 5mg $75 2024-03-01 Buy
Cayman Chemical 16613 UNC2025 ≥98% 1429881-91-3 10mg $135 2024-03-01 Buy
Cayman Chemical 16613 UNC2025 ≥98% 1429881-91-3 25mg $319 2024-03-01 Buy
Cayman Chemical 16613 UNC2025 ≥98% 1429881-91-3 50mg $600 2024-03-01 Buy
Usbiological 474206 UNC-2025 1429881-91-3 100mg $1677 2021-12-16 Buy
Product number Packaging Price Buy
16613 5mg $75 Buy
16613 10mg $135 Buy
16613 25mg $319 Buy
16613 50mg $600 Buy
474206 100mg $1677 Buy

UNC2025 Chemical Properties,Uses,Production

Description

UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo. Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min.

Uses

UNC 2025 is Mer/FLT3 dual inhibitor. It can be used in biological study. Novel MERTK inhibitor UNC2025 induced polyploidy and promoted death and senescence in human glioblastoma multiforme cells where high levels of GAS6 MERTK ligand expression correlated with decreased overall survival in patients.

in vitro

in duplicate versus 305 kinases at carna biosciences using a microcapillary electrophoresis assay, unc2025 inhibited mer and flt3 with the greatest potency. in b-all 697 cell lysates using the atp activx probe assay, unc2025 inhhibited the activity of mer with an ic50 of 0.05 nm. in 697 b-all cells, unc2025 potently inhibited mer phosphorylation with an ic50 of 2.7 nm. similarly, in flt3-itd positive molm-14 acute myeloid leukemia cells, treatment with unc2025 decreased phosphorylation of flt3 with an ic50 of 14 nm. in soft agar cultures of the a549 nsclc and molm-14 aml cell lines, incubation withunc2025 significantly inhibited colony formation, which was known to depend on merand flt3,respectively, for optimal expression of oncogenic phenotypes. much higher concentrations of unc2025 were required to effectively inhibit phosphorylation of axl (ic50 = 122 nm) and tyro3 (ic50 = 301 nm)[1].

in vivo

in mice with human leukemia xenografts, a single dose of unc2025 (3 mg/kg) administered orally was sufficient to decrease merphospho-protein levels in bone marrow leukemia cells by greater than 90% [1].

References

[1]. zhang w1,deryckere d,hunter d,liu j,stashko ma,minson ka, et,al. unc2025, a potent and orally bioavailablemer/flt3dual inhibitor.j med chem.2014 aug 28;57(16):7031-41. doi: 10.1021/jm500749d. epub 2014 aug 6.

UNC2025 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58

View Lastest Price from UNC2025 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
UNC2025 pictures 2019-12-23 UNC2025
1429881-91-3
US $1.00 / g 100g 99% G/KG/T Career Henan Chemical Co
  • UNC2025 pictures
  • UNC2025
    1429881-91-3
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

UNC2025 Spectrum

(1r,4r)-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimi UNC2025 (1R,4R)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol UNC-2025 mrx-6313 trans-4-(2-(Butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol UNC2025 HCl (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol CS-2109 UNC2025;UNC 2025 UNC-2025; UNC2025; UNC 2025. Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-,trans- 1429881-91-3 C28H40N6O