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IM-12

IM-12 structure

CAS No.: 1129669-05-1

Chemical Name:: IM-12

Synonyms: IM-12;CS-2144;CS-1819;IM-12 USP/EP/BP;The GSK3β Inhibitor XIX;THE GSK3Β INHIBITOR XIX; IM 12; IM-12;IM12;3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;Glycogen synthase kinase-3,Glycogen synthase kinase 3,IM12,Inhibitor,inhibit,IM-12,GSK-3;3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

CBNumber:: CB22716259

Molecular Formula:: C22H20FN3O2

Molecular Weight:: 377.41

MDL Number:: MFCD20527313

MOL File:: 1129669-05-1.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:20

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IM-12 Properties

Melting point	187 °C
Boiling point	600.2±55.0 °C(Predicted)
Density	1.34±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO: ≥9mg/mL
form	powder
pka	16.77±0.30(Predicted)
color	yellow-orange

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

WGK Germany

NFPA 704

	0
2		0

IM-12 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0084	IM-12 ≥98% (HPLC)	1129669-05-1	5mg	$136	2024-03-01	Buy
Sigma-Aldrich	SML0084	IM-12 ≥98% (HPLC)	1129669-05-1	25mg	$478	2022-05-15	Buy
Cayman Chemical	17673	IM-12 ≥98%	1129669-05-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	17673	IM-12 ≥98%	1129669-05-1	5mg	$70	2024-03-01	Buy
Cayman Chemical	17673	IM-12 ≥98%	1129669-05-1	10mg	$109	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0084	5mg	$136	Buy
SML0084	25mg	$478	Buy
17673	1mg	$32	Buy
17673	5mg	$70	Buy
17673	10mg	$109	Buy

IM-12 Chemical Properties,Uses,Production

Description

Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC₅₀ = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.

Uses

3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acts as an enhancer of Wnt signalling, involved in cell proliferation or differentiation, via inhibition of glycogen synthase kinase 3 beta (GSK-3β).

Definition

ChEBI: 3-[2-(4-fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione is an organonitrogen compound, an organooxygen compound and a member of maleimides. It is functionally related to an alpha-amino acid.

References

[1]. schmöle ac, brennführer a, karapetyan g, et al. novel indolylmaleimide acts as gsk-3beta inhibitor in human neural progenitor cells. bioorg med chem, 2010, 18(18): 6785-6795.

IM-12 synthesis

Synthesis of IM-12 from 1H-Pyrrole-2,5-dione, 3-bromo-1-methyl-4-(2-methyl-1H-indol-3-yl)- and 4-Fluorophenethylamine

IM-12 Preparation Products And Raw materials

Raw materials

1H-Pyrrole-2,5-dione, 3-bromo-1-methyl-4-(2-methyl-1H-indol-3-yl)- 4-Fluorophenethylamine carbon monoxide

Preparation Products

IM-12 Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
InvivoChem	58

View Lastest Price from IM-12 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	IM-12 1129669-05-1	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

IM-12
1129669-05-1
US $2.00 / kg
99%
Career Henan Chemical Co

IM-12 Spectrum

IM-12(1129669-05-1)¹HNMR

1129669-05-1(IM-12)Related Search:

Y27632 (hydrochloride) SB590885 PD 0325901 WH-4-023 GSK-3BETA INHIBITOR XII

CHIR-99021

1of2

IM-12 3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione IM-12 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione CS-1819 CS-2144 The GSK3β Inhibitor XIX THE GSK3Β INHIBITOR XIX; IM 12; IM-12;IM12 1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)- IM-12 USP/EP/BP Glycogen synthase kinase-3,Glycogen synthase kinase 3,IM12,Inhibitor,inhibit,IM-12,GSK-3 1129669-05-1 129669-05-1 Inhibitors