K-Ras(G12C) inhibitor 6
- CAS No.
- 2060530-16-5
- Chemical Name:
- K-Ras(G12C) inhibitor 6
- Synonyms
- CS-2013;MDK30165;K-Ras(G12C) inhibitor 6;K-Ras(G12C) inhibitor 6 USP/EP/BP;N-[1-[2-(2,4-dichlorophenoxy)acetyl]piperidin-4-yl]-4-sulfanylbutanamide;Butanamide, N-[1-[2-(2,4-dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-;N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide;Ras,inhibit,Inhibitor,K-Ras(G12C) inhibitor 6,K Ras(G12C) Inhibitor 6,KRas(G12C) Inhibitor 6,K-Ras(G-12C) Inhibitor 6
- CBNumber:
- CB22728650
- Molecular Formula:
- C17H22Cl2N2O3S
- Molecular Weight:
- 405.34
- MDL Number:
- MFCD28099807
- MOL File:
- 2060530-16-5.mol
| Boiling point | 643.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥20.25 mg/mL in DMSO |
| form | solid |
| pka | 10.21±0.10(Predicted) |
| FDA UNII | JPV55C3PN4 |
K-Ras(G12C) inhibitor 6 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | D438295 | N-[1-[2-(2,4-Dichlorophenoxy)acetyl]-4-piperidinyl]-4-mercapto-butanamide | 2060530-16-5 | 10mg | $470 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181272 | K-Ras(G12C) inhibitor 6 >98% | 2060530-16-5 | 100mg | $765 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181272 | K-Ras(G12C) inhibitor 6 >98% | 2060530-16-5 | 250mg | $1431.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181272 | K-Ras(G12C) inhibitor 6 >98% | 2060530-16-5 | 1000mg | $2691.1 | 2021-12-16 | Buy |
| ApexBio Technology | B3694 | K-Ras(G12C)inhibitor6 | 2060530-16-5 | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
K-Ras(G12C) inhibitor 6 Chemical Properties,Uses,Production
Uses
N-?[1-?[2-?(2,?4-Dichlorophenoxy)?acetyl]?-?4-?piperidinyl]?-?4-?mercapto-butanamide is an irreversible and allosteric inhibitor of the K-Ras(G12C) mutant. This compound has potential therapeutic application for diseases related to Ras signaling.
Biological Activity
k-ras (g12c) inhibitor 6 is an allosterical inhibitor of oncogenic mutation k-ras g12c [1].k-ras (g12c) inhibitor 6 is a cysteine-reactive small molecule. it irreversibly binds to the g12c mutantion of gtpase k-ras but not the wild-type k-ras with the relative potency value of 4.2. the binding pocket of k-ras for k-ras (g12c) inhibitor 6 is a new allosteric pocket, s-iip. binding of this pocket results in a change of the relative nucleotide affinity of ras to favour gdp over gtp, leading to an accumulation of inactive ras. since the mutation of k-ras is quite common in human cancers, the inhibitor of k-ras g12c should exert suppression activities in tumor cells. it has been reported that, some of the k-ras g12c inhibitors are indeed effective to decrease cell viability and increase apoptosis in lung cancer cell lines [1].
References
[1] ostrem j m, peters u, sos m l, et al. k-ras (g12c) inhibitors allosterically control gtp affinity and effector interactions. nature, 2013, 503(7477): 548-551.
K-Ras(G12C) inhibitor 6 Preparation Products And Raw materials
Raw materials
Preparation Products
K-Ras(G12C) inhibitor 6 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
View Lastest Price from K-Ras(G12C) inhibitor 6 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | K-Ras(G12C) inhibitor 6
2060530-16-5
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
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- K-Ras(G12C) inhibitor 6
2060530-16-5
- US $1.00 / g
- 99%
- Career Henan Chemical Co