LSD1-IN-1
- CAS No.
- 1431326-61-2
- Chemical Name:
- LSD1-IN-1
- Synonyms
- CS-1530;RG 6016;ORY-1001;LSD1-IN-1;RG6016) 2HCl;ORY-1001 2HCl salt;ORY-1001 (RG-6016);ORY-1001(LSD1-IN-1);Iadademstat (ORY-1001;ORY-1001 (RG-6016) 2HCl
- CBNumber:
- CB22739120
- Molecular Formula:
- C15H24Cl2N2
- Molecular Weight:
- 303.27046
- MDL Number:
- MFCD28900684
- MOL File:
- 1431326-61-2.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | insoluble in EtOH; ≥23.15 mg/mL in H2O; ≥6.9 mg/mL in DMSO with gentle warming |
| form | solid |
| CAS DataBase Reference | 1431326-61-2 |
| FDA UNII | XC0UT08SNJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
LSD1-IN-1 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19136 | ORY-1001 ≥98% | 1431326-61-2 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19136 | ORY-1001 ≥98% | 1431326-61-2 | 1mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 19136 | ORY-1001 ≥98% | 1431326-61-2 | 5mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 19136 | ORY-1001 ≥98% | 1431326-61-2 | 10mg | $426 | 2024-03-01 | Buy |
| TRC | O671003 | ORY-1001 | 1431326-61-2 | 10mg | $470 | 2021-12-16 | Buy |
LSD1-IN-1 Chemical Properties,Uses,Production
Description
Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370). ORY-1001 is an orally available, selective inhibitor of LSD1 (IC50 < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.
Uses
ORY-1001 is a potent LSD1 inhibitor.
in vitro
ory-1001 is an enantiomerically pure kdm1a inhibitor with high selectivity against related fad dependent aminoxidases. ory-1001 does not inhibit non-related histone modifiers, and is clean in a cerep diversity panel. treatment of thp-1 cells with ory-1001, results in a time/dose dependent me2h3k4 accumulation at kdm1a target genes and concomitant induction of differentiation markers [1].
in vivo
daily oral administration of doses < 0.020 mg/kg leads to significantly reduced tumor growth in rodent xenografts. in vivo studies have shown that ory-1001 presents excellent oral bioavailability, target exposure and activity in vivo [1].
IC 50
<20nm
LSD1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 3408 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
